Angewandte Chemie International Edition
Copyright © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Back Cover: Sticky Nanoparticles: A Platform for siRNA Delivery by a Bis(zinc(II) dipicolylamine)-Functionalized, Self-Assembled Nanoconjugate (Angew. Chem. Int. Ed. 2/2012)
A new platform for delivering siRNA is described by S. Lee, X. Chen, et al. in their Communication on page 445 ff. Multifunctional, self-assembled, polymeric nanoparticles composed of biodegradable hyaluronic acid, for selectively targeting tumors and cell penetration, and a phosphate-binding ZnII dipicolylamine analogue, for high siRNA binding affinity, provide simultaneous delivery of small-molecule drugs along with siRNA. This system offers additive and synergistic therapeutic effects.