Angewandte Chemie International Edition

Cover image for Vol. 54 Issue 20

Editor: Peter Gölitz, Deputy Editors: Neville Compton, Haymo Ross

Online ISSN: 1521-3773

Associated Title(s): Angewandte Chemie, Chemistry - A European Journal, Chemistry – An Asian Journal, ChemistryOpen, ChemPlusChem, Zeitschrift für Chemie

51_02b/2012Back Cover: Sticky Nanoparticles: A Platform for siRNA Delivery by a Bis(zinc(II) dipicolylamine)-Functionalized, Self-Assembled Nanoconjugate (Angew. Chem. Int. Ed. 2/2012)

A new platform for delivering siRNA is described by S. Lee, X. Chen, et al. in their Communication on page 445 ff. Multifunctional, self-assembled, polymeric nanoparticles composed of biodegradable hyaluronic acid, for selectively targeting tumors and cell penetration, and a phosphate-binding ZnII dipicolylamine analogue, for high siRNA binding affinity, provide simultaneous delivery of small-molecule drugs along with siRNA. This system offers additive and synergistic therapeutic effects.

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