Angewandte Chemie International Edition

Cover image for Vol. 56 Issue 23

Editor: Peter Gölitz, Deputy Editors: Neville Compton, Haymo Ross

Online ISSN: 1521-3773

Associated Title(s): Angewandte Chemie, Chemistry - A European Journal, Chemistry – An Asian Journal, ChemistryOpen, ChemPhotoChem, ChemPlusChem, Zeitschrift für Chemie

51_03c/2012Inside Back Cover: Characterization of the Reaction Path and Transition States for RNA Transphosphorylation Models from Theory and Experiment (Angew. Chem. Int. Ed. 3/2012)

The elucidation of RNA reaction mechanisms has a wide range of implications, from the origin of life to biotechnology. In their Communication on page 647 ff., K.-Y. Wong, J. A. Piccirilli, M. E. Harris, D. M. York, et al. report a joint theoretical and experimental study on kinetic isotope effects in models of RNA cleavage transesterification. The characteristics of the mechanism and the transition states are distinctly different in the reaction with the native compound relative to two thio-substituted analogues.

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