Angewandte Chemie International Edition
© WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Cover Picture: Crystal Structure of Methylornithine Synthase (PylB): Insights into the Pyrrolysine Biosynthesis (Angew. Chem. Int. Ed. 6/2012)
The unusual amino acid pyrrolysine is found in the active site of the methylamine methyltransferases of certain methanogenic archaea. Methylornithine, an intermediate in pyrrolysine biosynthesis, is formed by the PylB-catalyzed isomerization of lysine. In their Communication on page 1339 ff., M. Groll and co-workers present the crystal structure of PylB in complex with its reaction product and suggest a fragmentation–recombination mechanism via a glycyl radical intermediate.
Also of Interest
Alkane Activation by Bacteria
H. Wilkes et al. investigate the anaerobic C-H activation of n-alkanes by bacteria in their Communication on page 1334 ff. The reaction occurs stereospecifically, and the mechanism is in complete contrast to the known oxidation of alkanes by oxygenases.
Origami of Hydrogel Bilayers
In their Communication on page 1420 ff., S.-M. Yang and co-workers show planar bilayer microparticles composed of active and passive layers that can transform into microcapsules with a closed compartment.
Hydrated Ionic Liquids
In their Communication on page 1416 ff., H. Tateishi-Karimata and N. Sugimoto show that A–T base pairs are more stable than G–C base pairs in an ionic liquid.