Angewandte Chemie International Edition

Cover image for Vol. 54 Issue 32

Editor: Peter Gölitz, Deputy Editors: Neville Compton, Haymo Ross

Online ISSN: 1521-3773

Associated Title(s): Angewandte Chemie, Chemistry - A European Journal, Chemistry – An Asian Journal, ChemistryOpen, ChemPlusChem, Zeitschrift für Chemie

51_06/2012Cover Picture: Crystal Structure of Methylornithine Synthase (PylB): Insights into the Pyrrolysine Biosynthesis (Angew. Chem. Int. Ed. 6/2012)

The unusual amino acid pyrrolysine is found in the active site of the methylamine methyltransferases of certain methanogenic archaea. Methylornithine, an intermediate in pyrrolysine biosynthesis, is formed by the PylB-catalyzed isomerization of lysine. In their Communication on page 1339 ff., M. Groll and co-workers present the crystal structure of PylB in complex with its reaction product and suggest a fragmentation–recombination mechanism via a glycyl radical intermediate.

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Also of Interest

Alkane Activation by Bacteriafor001

H. Wilkes et al. investigate the anaerobic C-H activation of n-alkanes by bacteria in their Communication on page 1334 ff. The reaction occurs stereospecifically, and the mechanism is in complete contrast to the known oxidation of alkanes by oxygenases.

Origami of Hydrogel Bilayersfor002

In their Communication on page 1420 ff., S.-M. Yang and co-workers show planar bilayer microparticles composed of active and passive layers that can transform into microcapsules with a closed compartment.

Hydrated Ionic Liquidsfor003

In their Communication on page 1416 ff., H. Tateishi-Karimata and N. Sugimoto show that A–T base pairs are more stable than G–C base pairs in an ionic liquid.