Angewandte Chemie International Edition
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Back Cover: Switching the Targeting Pathways of a Therapeutic Antibody by Nanodesign (Angew. Chem. Int. Ed. 7/2012)
Gold nanoparticles can be used as a scaffold to elucidate the mechanism of endocytosis of cetuximab and its nanoconjugates, as well as the switching of endocytic pathways (caveolar versus pinocytotic) in pancreatic cancer cells, as demonstrated by P. Mukherjee and co-workers in their Communication on page 1563 ff. Tailoring the mechanism of endocytosis may be useful for targeting specific intracellular pathways to minimize the side effects of pharmaceutical compounds.