Angewandte Chemie International Edition

Cover image for Vol. 54 Issue 36

Editor: Peter Gölitz, Deputy Editors: Neville Compton, Haymo Ross

Online ISSN: 1521-3773

Associated Title(s): Angewandte Chemie, Chemistry - A European Journal, Chemistry – An Asian Journal, ChemistryOpen, ChemPlusChem, Zeitschrift für Chemie

51_07b/2012Back Cover: Switching the Targeting Pathways of a Therapeutic Antibody by Nanodesign (Angew. Chem. Int. Ed. 7/2012)

Gold nanoparticles can be used as a scaffold to elucidate the mechanism of endocytosis of cetuximab and its nanoconjugates, as well as the switching of endocytic pathways (caveolar versus pinocytotic) in pancreatic cancer cells, as demonstrated by P. Mukherjee and co-workers in their Communication on page 1563 ff. Tailoring the mechanism of endocytosis may be useful for targeting specific intracellular pathways to minimize the side effects of pharmaceutical compounds.

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