Angewandte Chemie International Edition
© WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Cover Picture: Dynamics and Multiple Stable Binding Modes of DNA Intercalators Revealed by Single-Molecule Force Spectroscopy (Angew. Chem. Int. Ed. 8/2012)
Intercalation of YOYO a bisintercalating DNA dye, was studied by using single-molecule force spectroscopy. In their Communication on page 1811 ff., D. H. Paik and T. T. Perkins show that force-enhanced intercalation, traditionally ascribed to the dye in solution binding to the DNA, can occur from a reservoir of bound dye that remained out of equilibrium with the free dye for long periods of time (>2 hours). Hence, binding/unbinding and intercalation/de-intercalation are distinct processes that can occur on very different time scales.
Also of Interest
A carbazole-based cyanine fluorophore is shown by H.-W. Li, K. K. L. Yung, M. S. Wong, and co-workers in their Communication on page 1804 ff. to inhibit Aβ(1–40) fibrillogenesis in the pathogenesis of Alzheimer's disease.
In their Communication on page 1820 ff., M. J. Macias, A. Riera, and co-workers describe that peptidic analogues obtained by replacing each phenylalanine with mesitylalanine are conformationally more rigid than the parent hormone somatostatin.
In their Communication on page 1816 ff., K. S. Anseth and C. A. DeForest report spatiotemporal control over the dynamic presentation of bioligands that are reversibly patterned into hydrogels by using two different photochemical reactions.