Angewandte Chemie International Edition
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Inside Cover: A Synthetic Approach Toward a Self-Regulated Insulin Delivery System (Angew. Chem. Int. Ed. 9/2012)
A totally synthetic artificial pancreas is described by Y. Miyahara et al. in their Communication on page 2124 ff. A hydrogel bearing a phenylboronate derivative undergoes a glucose-dependent transition in its state of hydration under physiological conditions. The reversible surface-localized dehydration enables the provision of insulin to be controlled, thus offering a new basis for the treatment of diabetes with long-term stability and safety.