Angewandte Chemie International Edition
© WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Cover Picture: In Vitro Developmental Acceleration of Hippocampal Neurons on Nanostructures of Self-Assembled Silica Beads in Filopodium-Size Ranges (Angew. Chem. Int. Ed. 12/2012)
Topographical cues play an important role in in vitro neuronal development. In their Communication on page 2855 ff., Y. Nam, I. S. Choi, J. S. Lee, and co-workers show that neuritogenetic acceleration occurs on silica-bead monolayers made up of beads with a diameter of more than 200 nm, but not on monolayers of beads with smaller diameters. The biochemical study indicates neurons sense topographical differences in nanostructures and alter their behavior accordingly.
Also of Interest
In their Communication on page 2850 ff., G. Wu and co-workers describe the three-dimensional free-energy landscapes for the movement of Na+, K+, and NH4+ ions through G-quadruplex DNA channels. They found that the ease of passage is related to ion size.
A micellar cross-linked nanocarrier for on-demand drug delivery is described by J. Luo, K. S. Lam, and co-workers in their Communication on page 2864 ff. Drug release occurs when the cross-links are cleaved by the acidic tumor environment or by exogenous cis-diols.
Enantioselective Gold Catalysis
S. Handa and L. M. Slaughter describe in their Communication on page 2912 ff. the influence of weak metal–π interactions in AuI complexes on the enantioselective catalysis of a tandem addition/cycloisomerization reaction.