Angewandte Chemie International Edition

Cover image for Vol. 55 Issue 23

Editor: Peter Gölitz, Deputy Editors: Neville Compton, Haymo Ross

Online ISSN: 1521-3773

Associated Title(s): Angewandte Chemie, Chemistry - A European Journal, Chemistry – An Asian Journal, ChemistryOpen, ChemPlusChem, Zeitschrift für Chemie

51_12c/2012Inside Back Cover: Well-Defined, Reversible Boronate Crosslinked Nanocarriers for Targeted Drug Delivery in Response to Acidic pH Values and cis-Diols (Angew. Chem. Int. Ed. 12/2012)

A cross-linked micellar nanocarrier system for on-demand drug delivery is described by J. Luo, K. S. Lam, and co-workers in their Communication on page 2864 ff. The reversible catechol boronate cross-link increases the stability of the nanocarriers against severe conditions in the blood stream. After the ball-like nanocarriers reach the tumor target, the cross-links are cleaved by the acidic tumor environment or by exogenous cis-diols (e.g. mannitol), causing the ball to burst and releasing the drug.

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