Angewandte Chemie International Edition

Cover image for Vol. 56 Issue 51

Editor: Neville Compton; Editor Emeritus: Peter Gölitz

Online ISSN: 1521-3773

Associated Title(s): Angewandte Chemie, Chemistry - A European Journal, Chemistry – An Asian Journal, ChemistryOpen, ChemPhotoChem, ChemPlusChem, Zeitschrift für Chemie

51_14/2012Cover Picture: The Crystal Structure of Human α2-Macroglobulin Reveals a Unique Molecular Cage (Angew. Chem. Int. Ed. 14/2012)

The large central cavity of the human methylamine-induced form of α2-macroglobulin (α2M) can accommodate two medium-sized proteinases, as shown by its crystal structure. In their Communication on page 3340 ff., F. X. Gomis-Rüth et al. show how the 720-KDa α2M traps prey proteinases by a major conformational rearrangement from an open to a closed form, a process reminiscent of the action of a Venus flytrap. Photos of a meal worm in a Venus flytrap courtesy of Beatrice Murch (

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Also of Interest

Small-Ring Compoundsfor001

The production of thiazylidynephosphane (SNP) from SP(N3)3 is described by J. S. Francisco et al. on page 3334 ff. The photointerconversion of SNP gives cyclic thiazaphosphirine, the first experimentally observed 16-electron cyclic triatomic molecule.

Stereoselective Synthesisfor002

The use of enantiomerically pure hypervalent iodine compounds enables metal-free highly stereoselective oxyaminations of alkenes and leads to a facile synthesis of 2-arylprolinols, as shown by T. Wirth and U. Farid in their Communication on page 3462 ff.

Zeolite Crystallizationfor003

Bio-inspired crystal engineering of nanoporous zeolites is described by A. I. Lupulescu and J. D. Rimer in their Communication on page 3345 ff. Molecular analogues of silica proteins in unicellular organisms are effective growth modifiers.