Angewandte Chemie International Edition

Cover image for Vol. 56 Issue 36

Editor: Peter Gölitz, Deputy Editors: Neville Compton, Haymo Ross

Online ISSN: 1521-3773

Associated Title(s): Angewandte Chemie, Chemistry - A European Journal, Chemistry – An Asian Journal, ChemistryOpen, ChemPhotoChem, ChemPlusChem, Zeitschrift für Chemie

51_15i/2012Inside Cover: Chemical Synthesis of an Erythropoietin Glycoform Containing a Complex-type Disialyloligosaccharide (Angew. Chem. Int. Ed. 15/2012)

A homogeneous glycoprotein was prepared by the improved tert-Boc solid-phase peptide synthesis of acid-labile sialylglycopeptide α-thioesters, sophisticated peptide-coupling reactions, and native chemical ligation. In their Communication on page 3567 ff., Y. Kajihara and co-workers report the chemical synthesis of a homogeneous erythropoietin glycoform bearing a complex-type biantennary disialyloligosaccharide. This approach will open a new avenue for the investigation of oligosaccharide function.

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