Angewandte Chemie International Edition

Cover image for Vol. 54 Issue 28

Editor: Peter Gölitz, Deputy Editors: Neville Compton, Haymo Ross

Online ISSN: 1521-3773

Associated Title(s): Angewandte Chemie, Chemistry - A European Journal, Chemistry – An Asian Journal, ChemistryOpen, ChemPlusChem, Zeitschrift für Chemie

51_18/2012Cover Picture: Trienamine Catalysis with 2,4-Dienones: Development and Application in Asymmetric Diels–Alder Reactions (Angew. Chem. Int. Ed. 18/2012)

An asymmetric Diels-Alder cycloaddition of δ,δ-disubstituted 2,4-dienones by trienamine catalysis with cinchona-based primary amines has been developed. In their Communication on page 4401 ff., Y.-C. Chen and co-workers show that a wide range of electron-deficient dienophiles were tolerated in this reaction to afford multifunctional cyclohexene derivatives with excellent stereoselectivity.

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Also of Interest

Enzyme Modelsfor001

The genetic incorporation of the amino acid imiTyr, which mimics a Tyr—His cross-link, into a myoglobin model of heme–copper oxidase (HCO) to give a functional HCO model is reported by Y. Lu, J. Wang et al. in their Communication on page 4312 ff.

Protein Purificationfor002

The noncovalent interaction between protein subunits derived from type 1 pili of E. coli forms the basis of a new affinity purification method described by R. Glockshuber and co-workers in their Communication on page 4474 ff.


In their Communication on page 4393 ff. G. A. van der Marel, J. D. C. Codée, and co-workers describe how mannuronic acid alginate fragments with up to 12 cis-mannosidic linkages can be prepared in multi-milligram quantities in a fully automated fashion.