Angewandte Chemie International Edition
© WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Cover Picture: Trienamine Catalysis with 2,4-Dienones: Development and Application in Asymmetric Diels–Alder Reactions (Angew. Chem. Int. Ed. 18/2012)
An asymmetric Diels-Alder cycloaddition of δ,δ-disubstituted 2,4-dienones by trienamine catalysis with cinchona-based primary amines has been developed. In their Communication on page 4401 ff., Y.-C. Chen and co-workers show that a wide range of electron-deficient dienophiles were tolerated in this reaction to afford multifunctional cyclohexene derivatives with excellent stereoselectivity.
Also of Interest
The genetic incorporation of the amino acid imiTyr, which mimics a Tyr—His cross-link, into a myoglobin model of heme–copper oxidase (HCO) to give a functional HCO model is reported by Y. Lu, J. Wang et al. in their Communication on page 4312 ff.
The noncovalent interaction between protein subunits derived from type 1 pili of E. coli forms the basis of a new affinity purification method described by R. Glockshuber and co-workers in their Communication on page 4474 ff.
In their Communication on page 4393 ff. G. A. van der Marel, J. D. C. Codée, and co-workers describe how mannuronic acid alginate fragments with up to 12 cis-mannosidic linkages can be prepared in multi-milligram quantities in a fully automated fashion.