Angewandte Chemie International Edition
© WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Cover Picture: Discovery and Target Identification of an Antiproliferative Agent in Live Cells Using Fluorescence Difference in Two-Dimensional Gel Electrophoresis (Angew. Chem. Int. Ed. 22/2012)
Target identification is the crown jewel of chemical biology. In their Communication on page 5447 ff., S. B. Park et al. have developed a new target identification method, fluorescence difference in two-dimensional gel electrophoresis (FITGE), to observe the interactions between proteins and small molecules in an intact cellular environment. FITGE successfully identifies protein differentiation between specific and nonspecific binding of photoaffinity probes.
Also of Interest
Silicon microcantilevers modified with a layer of vertical TiO2 nanotubes, which are inspired by the silkmoth sensilla, can be used to detect TNT. The sensor function is explained by V. Keller et al. on page 5334 ff. Photo of the silkmoth: Dominique Gellez.
D. A. Leigh et al. describe in their Communication on page 5480 ff. how a small molecule walks along a track and performs a task, namely quenching fluorescence at the end of the track.
M. F. Ruiz-López et al. describe on page 5413 ff. how the chemistry at the air–water interface of the atmospherically relevant radicals HO2. and O2.− is different from both the bulk and the gas-phase chemistry.