Angewandte Chemie International Edition
© WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Inside Cover: 6''-Thioether Tobramycin Analogues: Towards Selective Targeting of Bacterial Membranes (Angew. Chem. Int. Ed. 23/2012)
Amphiphilic aminoglycoside antibiotics kill bacteria by disruption of their highly negatively charged membrane. In their Communication on page 5652 ff., M. Fridman, S. Garneau-Tsodikova, and co-workers report the synthesis of 6''-thioether tobramycin derivatives and show that their aliphatic chain acts as a drill bit that can rupture bacterial cells. These potent compounds evade many of the common bacterial resistance mechanisms, thereby opening a new avenue for the discovery of membrane-targeting antibiotics.