Angewandte Chemie International Edition
Copyright © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Inside Cover: Csp3-H Bond Activation Triggered by Formation of Metallacycles: Rhodium(I)-Catalyzed Cyclopropanation/Cyclization of Allenynes (Angew. Chem. Int. Ed. 29/2012)
Transition-metal-catalyzed activations of Csp3-H bonds usually need the assistance of directing groups for site-selective activation. In their Communication on page 7305 ff., Y. Oonishi, Y. Sato, and co-workers describe a new method for the activation of Csp3-H bonds; this activation is triggered by the formation of a metallacycle. In the picture, the statue of Dr. William S. Clark points out the hydrogen that should be activated in the key step of this reaction.