Angewandte Chemie International Edition
© WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Cover Picture: Convergent Asymmetric Synthesis of (+)-Aureothin Employing an Oxygenase-Mediated Resolution Step (Angew. Chem. Int. Ed. 38/2012)
Maximized convergence is the key in the assembly of the carbon backbone of the densely functionalized natural product (+)-aureothin, as C. Hertweck and M. De Paolis et al. report in their Communication on page 9587 ff. The final step in the synthesis is the regiodivergent parallel kinetic resolution of the racemic precursor through in vivo treatment with a cytochrome P450 monooxygenase. (Background photography courtesy of Nico Überschaar; the authors also thank Martin E. A. Richter and Jonathan Rangapanaiken for their contribution to the cover picture.)
Also of Interest
In their Communication on page 9512 ff. A. Antonchick, H. Waldmann, et al. describe a catalytic enantioselective [6+3] cycloaddition of azomethine ylides with fulvenes to give piperidine derivatives with four stereocenters.
In their Communication on page 9596 ff., T. Pradeep et al. report a technique that allows for the visual detection of tens of molecules of trinitrotoluene through the luminescence quenching of a hybrid material.
Water-splitting catalysis can be exploited as a source of electrons and protons to make clean, renewable fuels such as hydrogen, thus mimicking photosynthesis. In their Communication on page 9601 ff., K. S. Joya, H. J. M. de Groot, et al. show how surface-immobilized mono-site iridium complexes used as electrocatalysts can generate O2 at a high rate and turnover numbers of more than 200 000.