Angewandte Chemie International Edition

Cover image for Vol. 55 Issue 27

Editor: Peter Gölitz, Deputy Editors: Neville Compton, Haymo Ross

Online ISSN: 1521-3773

Associated Title(s): Angewandte Chemie, Chemistry - A European Journal, Chemistry – An Asian Journal, ChemistryOpen, ChemPlusChem, Zeitschrift für Chemie

51_38/2012Cover Picture: Convergent Asymmetric Synthesis of (+)-Aureothin Employing an Oxygenase-Mediated Resolution Step (Angew. Chem. Int. Ed. 38/2012)

Maximized convergence is the key in the assembly of the carbon backbone of the densely functionalized natural product (+)-aureothin, as C. Hertweck and M. De Paolis et al. report in their Communication on page 9587 ff. The final step in the synthesis is the regiodivergent parallel kinetic resolution of the racemic precursor through in vivo treatment with a cytochrome P450 monooxygenase. (Background photography courtesy of Nico Überschaar; the authors also thank Martin E. A. Richter and Jonathan Rangapanaiken for their contribution to the cover picture.)

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Also of Interest

Asymmetric Catalysisfor001

In their Communication on page 9512 ff. A. Antonchick, H. Waldmann, et al. describe a catalytic enantioselective [6+3] cycloaddition of azomethine ylides with fulvenes to give piperidine derivatives with four stereocenters.


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