Angewandte Chemie International Edition

Cover image for Vol. 56 Issue 44

Editor: Neville Compton; Editor Emeritus: Peter Gölitz

Online ISSN: 1521-3773

Associated Title(s): Angewandte Chemie, Chemistry - A European Journal, Chemistry – An Asian Journal, ChemistryOpen, ChemPhotoChem, ChemPlusChem, Zeitschrift für Chemie

51_41b/2012Back Cover: Observation of Subcellular Metabolite Gradients in Single Cells by Laser Ablation Electrospray Ionization Mass Spectrometry (Angew. Chem. Int. Ed. 41/2012)

Combining cell microdissection with laser ablation electrospray ionization (LAESI) mass spectrometry enables the metabolic profiling of subcellular compartments, as shown by A. Vertes and co-workers in their Communication on page 10386 ff. The use of LAESI mass spectrometry allowed the dissected cell to be studied in its natural tissue-embedded state. Large metabolite gradients between the nucleus and the cytoplasm were revealed and over 30 metabolites were detected in a large cell compartment, for example the nucleus.

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