Angewandte Chemie International Edition

Cover image for Vol. 53 Issue 52

Editor: Peter Gölitz, Deputy Editors: Neville Compton, Haymo Ross

Online ISSN: 1521-3773

Associated Title(s): Angewandte Chemie, Chemistry - A European Journal, Chemistry – An Asian Journal, ChemistryOpen, ChemPlusChem, Zeitschrift für Chemie

51_43b/2012Back Cover: A Phenylboronate-Functionalized Polyion Complex Micelle for ATP-Triggered Release of siRNA (Angew. Chem. Int. Ed. 43/2012)

Delivery of small interfering RNA is described by K. Kataoka et al. in their Communication on page 10751 ff. siRNA encapsulated in a phenylboronate-functionalized polyion complex micelle shows specific binding between the pendent phenylboronate and the 3'-ribose moiety of the siRNA, stabilizing the complex under extracellular conditions. This complex is disrupted upon addition of ATP at a concentration comparable to that inside cells.

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