Angewandte Chemie International Edition
Copyright © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Inside Cover: Selective RNA Versus DNA G-Quadruplex Targeting by In Situ Click Chemistry (Angew. Chem. Int. Ed. 44/2012)
The rational design of small molecules to selectively target a defined RNA is highly challenging. Such probes ultimately provide the means to interrogate RNA functions within a cellular context with high temporal resolution. In their Communication on page 11073 ff., R. Rodriguez, S. Balasubramanian, and co-workers report the use of in situ click chemistry to identify a small molecule that selectively interacts with the telomeric repeat-containing RNA (TERRA) through recognition of the G-quadruplex structure. The same approach was used to identify a related analogue that targets its DNA counterpart with high efficiency.