Angewandte Chemie International Edition

Cover image for Vol. 54 Issue 49

Editor: Peter Gölitz, Deputy Editors: Neville Compton, Haymo Ross

Online ISSN: 1521-3773

Associated Title(s): Angewandte Chemie, Chemistry - A European Journal, Chemistry – An Asian Journal, ChemistryOpen, ChemPlusChem, Zeitschrift für Chemie

51_49c/2012Inside Back Cover: Discovery of Small-Molecule Inhibitors of the TLR1/TLR2 Complex (Angew. Chem. Int. Ed. 49/2012)

Toll-like receptors (TLRs) play pivotal roles in innate immunity. Two key members of the TLR protein family, TLR1 (orange) and TLR2 (magenta), form a heterodimeric complex that recognizes pathogen-associated molecule patterns such as Pam3CSK4 (green) and activates inflammation response. On page 12246 ff., H. Yin and co-workers describe the new inhibitor CU-CPT22 (white), which displaces bound Pam3CSK4 from the TLR1–TLR2 complex, thus providing a valuable probe for these important signaling receptors.

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