Angewandte Chemie International Edition
© WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Inside Back Cover: Light-Triggered Sequence-Specific Cargo Release from DNA Block Copolymer–Lipid Vesicles (Angew. Chem. Int. Ed. 3/2013)
Sequence-specific cargo release from DNA-encoded lipid vesicles through the stable tagging of a liposome surface with amphiphilic DNA block copolymers (DBCs) is reported by A. Herrmann and co-workers in their Communication on page 1008 ff. Hybridization of anchored DBCs with an oligonucleotide photosensitizer is the key to light-induced singlet oxygen generation close to the lipid membrane, which results in the oxidation of polymer anchors and/or unsaturated phospholipids, leading to release of the vesicle payload.