Angewandte Chemie International Edition

Cover image for Vol. 55 Issue 7

Chefredakteur: Peter Gölitz, Stellvertreter: Neville Compton, Haymo Ross

Online ISSN: 1521-3773

Associated Title(s): Angewandte Chemie, Chemistry - A European Journal, Chemistry – An Asian Journal, ChemistryOpen, ChemPlusChem, Zeitschrift für Chemie

52_18/2013Cover Picture: Maillard Degradation Pathways of Vitamin C (Angew. Chem. Int. Ed. 18/2013)

Even 80 years after the elucidation of the structure of l-threo-ascorbic acid (vitamin C), the chemistry of this reactive reducing carbohydrate remains exciting. In their Communication on page 4887 ff., M. A. Glomb and M. Smuda report on their investigations into the Maillard degradation pathway, which revealed three major fragmentation mechanisms that lead to carbonyl and dicarbonyl compounds, carboxylic acids, and amide advanced glycation endproducts.

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Also of Interest

Even 80 years after the elucidation of the structure of l-threo-ascorbic acid (vitamin C), the chemistry of this reactive reducing carbohydrate remains exciting. In their Communication on page 4887 ff., M. A. Glomb and M. Smuda report on their investigations into the Maillard degradation pathway, which revealed three major fragmentation mechanisms that lead to carbonyl and dicarbonyl compounds, carboxylic acids, and amide advanced glycation endproducts.

Protein Arrays in Cellsfor001

The protein-interaction arrays described by P. I. H. Bastiaens, L. Dehmelt et al. in their Communication on page 4790 ff. were used for the simultaneous monitoring of the interaction kinetics of a prey protein with two distinct bait proteins in individual living cells.


Protein Engineeringfor002

In their Communication on page 4805 ff., J. Y. Wang and co-workers describe the synthesis and incorporation of an 8-hydroxyquinoline-modified amino acid into fluorescent proteins. This metal-chelating moiety causes the emission spectra of the proteins to be red-shifted.


Posttranslational Modificationsfor003

A probe for malonylation of lysine, a newly discovered posttranslational modification, is described by Y. M. E. Fung, X. D. Li, et al. in their Communication on page 4883 ff. This probe can be used for detecting modifications in living cells.


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