Angewandte Chemie International Edition

Cover image for Vol. 54 Issue 49

Editor: Peter Gölitz, Deputy Editors: Neville Compton, Haymo Ross

Online ISSN: 1521-3773

Associated Title(s): Angewandte Chemie, Chemistry - A European Journal, Chemistry – An Asian Journal, ChemistryOpen, ChemPlusChem, Zeitschrift für Chemie

52_18c/2013Inside Back Cover: Significant Expansion of the Fluorescent Protein Chromophore through the Genetic Incorporation of a Metal-Chelating Unnatural Amino Acid (Angew. Chem. Int. Ed. 18/2013)

A metal-chelating unnatural amino acid (UAA) with an 8-hydroxyquinoline functional group (HqAla) was enzymatically synthesized in one step. In their Communication on page 4805 ff., J. Y. Wang and co-workers show that incorporation of HqAla into fluorescent proteins shifts their emission maxima toward higher wavelengths (red-shifted). This UAA could be applied to engineering metalloproteins and brighter fluorescent proteins, as well as paramagnetic protein NMR spectroscopy.

| Table of Contents