Angewandte Chemie International Edition
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Inside Back Cover: General and Efficient Synthesis of Indoles through Triazene-Directed C–H Annulation (Angew. Chem. Int. Ed. 22/2013)
Directed C-H annulation reactions provide a straightforward solution to the synthesis of substituted indoles. In their Communication on page 5795 ff., Y. Huang and co-workers describe a general protocol for the synthesis of unprotected indoles. By using a cleavable triazene as the directing group, C-H annulation with a wide scope of alkynes was accomplished with excellent regioselectivity for both aryl,alkyl and alkyl,alkyl disubstituted acetylenes.