Angewandte Chemie International Edition
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Back Cover: The Fatty Acid Composition of Diacylglycerols Determines Local Signaling Patterns (Angew. Chem. Int. Ed. 24/2013)
Photoactivatable or “caged” derivatives of signaling molecules are important tools for manipulating intracellular events with spatial and temporal resolution. In their Communication on page 6330 ff., C. Schultz and co-workers demonstrate that regionally limited photoactivation simultaneously leads to a local protein kinase C and a global calcium response. Surprisingly, the orchestration of these effects seems to depend on the fatty acid composition of the released lipid.