Angewandte Chemie International Edition
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Inside Cover: Total Synthesis of (±)-Aspidophylline A (Angew. Chem. Int. Ed. 7/2014)
The total synthesis of the monoterpene alkaloid aspidophylline A is described by J. Zhu and et. al. in their Communication on page 1818 ff. The concise synthetic strategy features rapid access to the pentacyclic skeleton of aspidophylline A by using intramolecular Michael additions as key steps. The strategy could potentially provide a feasible route to other congeners of the akuammiline family of alkaloids.