Angewandte Chemie International Edition

Cover image for Vol. 56 Issue 6

Editor: Peter Gölitz, Deputy Editors: Neville Compton, Haymo Ross

Online ISSN: 1521-3773

Associated Title(s): Angewandte Chemie, Chemistry - A European Journal, Chemistry – An Asian Journal, ChemistryOpen, ChemPhotoChem, ChemPlusChem, Zeitschrift für Chemie

53_12/2014Cover Picture: Monitoring Conformational Changes in the NDM-1 Metallo-β-lactamase by 19F NMR Spectroscopy (Angew. Chem. Int. Ed. 12/2014)

Increasing antibiotic resistance is a global health concern. Metallo-β-lactamases catalyze the hydrolysis of almost all β-lactam antibiotics. T. D. W. Claridge, C. J. Schofield et al. show in their Communication on page 3129 ff. how 19F NMR spectroscopy can be used to investigate the binding mode of inhibitors to the New Delhi Metallo-β-lactamase I (NDM-1). By labeling an active-site loop with 19F, changes in the local chemical environment caused by inhibitor binding can be readily monitored by NMR spectroscopy.

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Also of Interest

Increasing antibiotic resistance is a global health concern. Metallo-β-lactamases catalyze the hydrolysis of almost all β-lactam antibiotics. T. D. W. Claridge, C. J. Schofield et al. show in their Communication on page 3129 ff. how 19F NMR spectroscopy can be used to investigate the binding mode of inhibitors to the New Delhi Metallo-β-lactamase I (NDM-1). By labeling an active-site loop with 19F, changes in the local chemical environment caused by inhibitor binding can be readily monitored by NMR spectroscopy.

Antiaromatic Batteriesfor001

A rechargeable battery with an antiaromatic norcorrole NiII complex as a cathode-active material and a Li metal anode is described in the Communication by H. Yoshikawa, K. Awaga, H. Shinokubo and co-workers on page 3096 ff.


Metallofullerenesfor002

K. Itami, H. Shinohara et al. describe in their Communication on page 3102 ff., a new strategy for the nonchromatographic extraction of metallofullerenes from solutions of arc-processed raw soot.


C-H Activationfor003

In their Communication on page 3120 ff., Z. Li et al. describe the development of an enzyme by the directed evolution of terminal-selective P450pyr hydroxylase for the regio- and enantioselective subterminal hydroxylation of an alkane.


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