Angewandte Chemie International Edition
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Back Cover: Engineering of P450pyr Hydroxylase for the Highly Regio- and Enantioselective Subterminal Hydroxylation of Alkanes (Angew. Chem. Int. Ed. 12/2014)
P450 enzymes that were obtained by the directed evolution of terminal-selective P450pyr hydroxylase enabled the first highly regio- and enantioselective subterminal hydroxylation of an alkane at a non-activated carbon atom, as described by Z. Li and co-workers in their Communication on page 3120 ff. The engineered P450 enzymes are useful catalysts for the regio- and stereoselective functionalization of alkanes and the preparation of enantiopure alcohols.