Angewandte Chemie International Edition

Cover image for Vol. 56 Issue 36

Editor: Peter Gölitz, Deputy Editors: Neville Compton, Haymo Ross

Online ISSN: 1521-3773

Associated Title(s): Angewandte Chemie, Chemistry - A European Journal, Chemistry – An Asian Journal, ChemistryOpen, ChemPhotoChem, ChemPlusChem, Zeitschrift für Chemie

53_16b/2014Back Cover: The Bioinorganic Chemistry of Apoptosis: Potential Inhibitory Zinc Binding Sites in Caspase-3 (Angew. Chem. Int. Ed. 16/2014)

Zinc ions and copper ions are known to play important and contrasting roles in apoptosis, with zinc inhibiting the pro-apoptotic protein caspase-3. In their Communication on page 4098 ff., N. P. Farrell and co-workers present evidence that zinc inhibits caspase-3 through interacting with the active-site histidine residue rather than with the catalytic dyad as had previously been assumed.

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