Angewandte Chemie International Edition

Cover image for Vol. 56 Issue 10

Editor: Peter Gölitz, Deputy Editors: Neville Compton, Haymo Ross

Online ISSN: 1521-3773

Associated Title(s): Angewandte Chemie, Chemistry - A European Journal, Chemistry – An Asian Journal, ChemistryOpen, ChemPhotoChem, ChemPlusChem, Zeitschrift für Chemie

53_17/2014Cover Picture: Short Chemoenzymatic Total Synthesis of ent-Hydromorphone: An Oxidative Dearomatization/Intramolecular [4+2] Cycloaddition/Amination Sequence (Angew. Chem. Int. Ed. 17/2014)

A 12-step chemoenzymatic total synthesisof ent-hydromorphone from β-bromoethylbenzene is described by T. Hudlicky and V. Varghese in their Communication on page 4355 ff. The key steps consist of enzymatic dihydroxylation, Mitsunobu coupling, and oxidative dearomatization followed by intramolecular [4+2] cycloaddition. This approach holds potential for further optimization of morphine alkaloid syntheses. We acknowledge the legendary efforts of the chemists pictured, who dedicated their careers to the chemistry of morphine. Cover design: Dennis Ceci, Tomas Hudlicky, Jordan Froese (Brock University).

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Also of Interest

A 12-step chemoenzymatic total synthesisof ent-hydromorphone from β-bromoethylbenzene is described by T. Hudlicky and V. Varghese in their Communication on page 4355 ff. The key steps consist of enzymatic dihydroxylation, Mitsunobu coupling, and oxidative dearomatization followed by intramolecular [4+2] cycloaddition. This approach holds potential for further optimization of morphine alkaloid syntheses. We acknowledge the legendary efforts of the chemists pictured, who dedicated their careers to the chemistry of morphine. Cover design: Dennis Ceci, Tomas Hudlicky, Jordan Froese (Brock University).

Solid-State NMR Spectroscopyfor001

In their Communication on page 4312 ff., P. Schanda et al. describe an NMR method used to probe conformational states of proteins. Information about the exchange kinetics, relative populations, and structures of the short-lived state can be obtained.


Natural Product Synthesisfor002

M. Wilsdorf and H.-U. Reissig describe a convergent total synthesis of (±)-γ-rubromycin in their Communication on page 4332 ff. Three highly functionalized building blocks are combined through selective organometallic chemistry.


Functional Polymer Layersfor003

In their Communication on page 4465 ff., Y. Wang et al. report functional polymer layers on paper. Near-infrared light was used to change the conductivity and wettability of the polymers.


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