Angewandte Chemie International Edition
© WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Inside Back Cover: A Convergent Total Synthesis of the Telomerase Inhibitor (±)-γ-Rubromycin (Angew. Chem. Int. Ed. 17/2014)
Silicon in, silicon out could be the caption for the convergent total synthesis of the telomerase inhibitor (±)-γ-rubromycin reported by M. Wilsdorf and H.-U. Reissig in their Communication on page 4332 ff. They combine three highly functionalized building blocks through selective organometallic chemistry and a silyl-substituted C3 building block plays a key role. Three acid-promoted reactions serve to generate the sensitive spiroketal natural product under desilylation. Graphic courtesy of Dr. Daniel Trawney.