Angewandte Chemie International Edition

Cover image for Vol. 55 Issue 27

Editor: Peter Gölitz, Deputy Editors: Neville Compton, Haymo Ross

Online ISSN: 1521-3773

Associated Title(s): Angewandte Chemie, Chemistry - A European Journal, Chemistry – An Asian Journal, ChemistryOpen, ChemPlusChem, Zeitschrift für Chemie

53_17c/2014Inside Back Cover: A Convergent Total Synthesis of the Telomerase Inhibitor (±)-γ-Rubromycin (Angew. Chem. Int. Ed. 17/2014)

Silicon in, silicon out could be the caption for the convergent total synthesis of the telomerase inhibitor (±)-γ-rubromycin reported by M. Wilsdorf and H.-U. Reissig in their Communication on page 4332 ff. They combine three highly functionalized building blocks through selective organometallic chemistry and a silyl-substituted C3 building block plays a key role. Three acid-promoted reactions serve to generate the sensitive spiroketal natural product under desilylation. Graphic courtesy of Dr. Daniel Trawney.

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