Angewandte Chemie International Edition

Cover image for Vol. 53 Issue 52

Editor: Peter Gölitz, Deputy Editors: Neville Compton, Haymo Ross

Online ISSN: 1521-3773

Associated Title(s): Angewandte Chemie, Chemistry - A European Journal, Chemistry – An Asian Journal, ChemistryOpen, ChemPlusChem, Zeitschrift für Chemie

53_17i/2014Inside Cover: Identification and X-ray Co-crystal Structure of a Small-Molecule Activator of LFA-1-ICAM-1 Binding (Angew. Chem. Int. Ed. 17/2014)

The immune response regulating the protein–protein interaction of the integrin leucocyte function associated antigen 1 and intercellular adhesion molecule 1 is allosterically enhanced by the binding of IBE-667 to a remote site on LFA-1. M. Hintersteiner, M. Auer, and co-workers show in their Communication on page 4322 ff. that the identification of IBE-667 can be achieved through a combinatorial library screening approach with several techniques.

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