Angewandte Chemie International Edition
© WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Inside Cover: Identification and X-ray Co-crystal Structure of a Small-Molecule Activator of LFA-1-ICAM-1 Binding (Angew. Chem. Int. Ed. 17/2014)
The immune response regulating the protein–protein interaction of the integrin leucocyte function associated antigen 1 and intercellular adhesion molecule 1 is allosterically enhanced by the binding of IBE-667 to a remote site on LFA-1. M. Hintersteiner, M. Auer, and co-workers show in their Communication on page 4322 ff. that the identification of IBE-667 can be achieved through a combinatorial library screening approach with several techniques.