Angewandte Chemie International Edition

Cover image for Vol. 53 Issue 30

Editor: Peter Gölitz, Deputy Editors: Neville Compton, Haymo Ross

Online ISSN: 1521-3773

Associated Title(s): Angewandte Chemie, Chemistry - A European Journal, Chemistry – An Asian Journal, Zeitschrift für Chemie

53_24/2014Cover Picture: Cytoskeletal Actin Dynamics are Involved in Pitch-Dependent Neurite Outgrowth on Bead Monolayers (Angew. Chem. Int. Ed. 24/2014)

Pitch-dependent neurite outgrowth was demonstrated in primary hippocampal neurons on monolayers of silica beads. In their Communication on page 6075 ff., Y. Nam, J. S. Lee, I. S. Choi, and co-workers report that neurite outgrowth is accelerated on larger beads (white) compared to smaller beads (black) up to a bead diameter of approximately 1 μm. Biochemical analysis indicated that cytoskeletal actin dynamics are primarily responsible for the recognition of surface topography.

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Also of Interest

Pitch-dependent neurite outgrowth was demonstrated in primary hippocampal neurons on monolayers of silica beads. In their Communication on page 6075 ff., Y. Nam, J. S. Lee, I. S. Choi, and co-workers report that neurite outgrowth is accelerated on larger beads (white) compared to smaller beads (black) up to a bead diameter of approximately 1 μm. Biochemical analysis indicated that cytoskeletal actin dynamics are primarily responsible for the recognition of surface topography.

NMR Fingerprintsfor001

1H NMR fingerprints are used to identify novel compounds including iotrochotazine A. This natural product has activity on a human Parkinson's disease cell model, as reported by R. J. Quinn and co-workers in their Communication on page 6070 ff.


Umpolungfor002

In their Communication on page 6184 ff., G. Doisneau, J.-M. Beau et al. describe the chemoselective reductive coupling of carbonyl compounds with glycals that is induced by samarium diiodide.


Drug Deliveryfor003

R. Mo, C. Zhang et al. show in their Communication on page 6253 ff. how a pH-responsive nanogel is used to penetrate tumor cells, release a chemotherapeutic, and then, after release for the cell, infect further tumor cells.


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