Angewandte Chemie International Edition

Cover image for Vol. 53 Issue 36

Editor: Peter Gölitz, Deputy Editors: Neville Compton, Haymo Ross

Online ISSN: 1521-3773

Associated Title(s): Angewandte Chemie, Chemistry - A European Journal, Chemistry – An Asian Journal, Zeitschrift für Chemie

53_36/2014Cover Picture: Sulfur(VI) Fluoride Exchange (SuFEx): Another Good Reaction for Click Chemistry (Angew. Chem. Int. Ed. 36/2014)

A completely new click chemistry is described by K. B. Sharpless, M. G. Finn, and co-workers in their Review on page 9430 ff. The robust bond between SVI and F atoms (such as in the gas SO2F2 and Michael acceptor HC=CHSO2F) can be specifically activated by proton (often in the form of the bifluoride ion, HF2) or silicon centers (e.g. an aryl silyl ether) to create S–heteroatom linkages of surprising stability. Applications of this click 2.0 method to the synthesis of small molecules or polymers (see the Communication by K. B. Sharpless, V. V. Fokin et al. on page 9466 ff.), and the modification of biomolecules—each represented at the periphery of the image—are discussed.

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Also of Interest

A completely new click chemistry is described by K. B. Sharpless, M. G. Finn, and co-workers in their Review on page 9430 ff. The robust bond between SVI and F atoms (such as in the gas SO2F2 and Michael acceptor HC=CHSO2F) can be specifically activated by proton (often in the form of the bifluoride ion, HF2) or silicon centers (e.g. an aryl silyl ether) to create S–heteroatom linkages of surprising stability. Applications of this click 2.0 method to the synthesis of small molecules or polymers (see the Communication by K. B. Sharpless, V. V. Fokin et al. on page 9466 ff.), and the modification of biomolecules—each represented at the periphery of the image—are discussed.

Tandem Peptide Cyclizationfor001

A. Friedler et al. describe in their Communication on page 9450 ff. a tandem strategy involving in situ deprotection, cyclization, and trifluoroacetic acid cleavage for the solid-phase cyclization of peptides under highly acidic conditions.


Bioorthogonal Imagingfor002

H. Mikula, C. Kuntner, et al. describe the synthesis and application of a low-molecular-weight radiolabeled tetrazine derivative in their Communication on page 9655 ff. This compound is a suitable reagent for pretargeted PET imaging.


Protein Mass Spectrometryfor003

Multiple aspects of protein phosphorylation can be examined simultaneously by a combination of native and “bottom-up” mass spectrometry. This method is described by A. J. R. Heck et al. in their Communication on page 9660 ff.


53_36i/2014Inside Cover: Syntheses, Structures, and Reactivities of Two Chalcogen-Stabilized Carbones (Angew. Chem. Int. Ed. 36/2014)

New carbones of the type Ph2E[RIGHTWARDS ARROW]C[LEFTWARDS ARROW]SPh2(NMe) (E=S or Se) were synthesized and characterized. T. Fujii et al. show in their Communication on page 9569 ff. that the double protonation of Ph2Se[RIGHTWARDS ARROW]C[LEFTWARDS ARROW]SPh2(NMe) gives a dication, whereas a C-metalated trication is obtained with silver(I). These reactions constitute the first experimental evidence for a carbodichalcogenurane behaving as a four-electron donor ligand.

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53_36c/2014Inside Back Cover: Development of a 18F-Labeled Tetrazine with Favorable Pharmacokinetics for Bioorthogonal PET Imaging (Angew. Chem. Int. Ed. 36/2014)

Bioorthogonal PET probes serve as highly valuable tools in the field of pretargeted molecular imaging. In their Communication on page 9655 ff., H. Mikula, C. Kuntner, and co-workers describe the development, synthesis, and characterization of a low-molecular-weight 18F-labeled tetrazine derivative that can be used for bioorthogonal PET imaging of dienophile-tagged (bio)molecules through the application of in vivo chemistry.

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53_36b/2014Back Cover: Simultaneous Assessment of Kinetic, Site-Specific, and Structural Aspects of Enzymatic Protein Phosphorylation (Angew. Chem. Int. Ed. 36/2014)

Multiple aspects of protein phosphorylation can be addressed simultaneously by an analytical method described by A. J. R. Heck and co-workers in their Communication on page 9660 ff. Their approach integrates native and bottom-up mass spectrometry and provides insight into the site specificity, kinetics, and structural effects of this biochemical process.

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