Angewandte Chemie International Edition

Cover image for Vol. 53 Issue 35

Editor: Peter Gölitz, Deputy Editors: Neville Compton, Haymo Ross

Online ISSN: 1521-3773

Associated Title(s): Angewandte Chemie, Chemistry - A European Journal, Chemistry – An Asian Journal, Zeitschrift für Chemie

53_35/2014Cover Picture: Evidence of a Kinetic Isotope Effect in Nanoaluminum and Water Combustion (Angew. Chem. Int. Ed. 35/2014)

Kinetic limitation ... ... of nanoparticulate aluminum (nAl) combustion has never been observed. Therefore the reaction is often described as solely diffusion-controlled. In their Communication on page 9218 ff., B. C. Tappan and co-workers present the combustion analysis of nAl with H2O or D2O and measure a distinct kinetic isotope effect. This observation verifies that reaction kinetics play a major role in determining the global burning rate as particle sizes reach the nanoscale.

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Also of Interest

Kinetic limitation ... ... of nanoparticulate aluminum (nAl) combustion has never been observed. Therefore the reaction is often described as solely diffusion-controlled. In their Communication on page 9218 ff., B. C. Tappan and co-workers present the combustion analysis of nAl with H2O or D2O and measure a distinct kinetic isotope effect. This observation verifies that reaction kinetics play a major role in determining the global burning rate as particle sizes reach the nanoscale.

DNA Labelingfor001

U. Rieder and N. W. Luedtke report the incorporation of 5-vinyl-2'-deoxyuridine (VdU) into cellular DNA in their Communication on page 9168 ff. The VdU can then be visualized through Diels–Alder reactions with fluorescent tetrazines.


Protein Mass Spectrometryfor002

In their Communication on page 9183 ff. Bergese, E. Dalcanale, et al. describe a supramolecular nanomechanical device for the label-free detection of the whole class of methamphetamines in water.


STAT3 Dimerizationfor003

A substitutionally inert, organometallic rhodium(III) complex inhibits the dimerization of STAT3 in vitro and in vivo, as reported by D.-L. Ma, C.-H. Leung, H.-M. D. Wang et al. in their Communication on page 9178 ff.


53_35i/2014Inside Cover: Molecularly Designed Nanoparticles by Dispersion of Self-Assembled Organosiloxane-Based Mesophases (Angew. Chem. Int. Ed. 35/2014)

Silica–organic hybrid nanoparticles are described by K. Kuroda, A. Shimojima, and co-workers in their Communication on page 9173 ff. First, reverse mesostructures are obtained by the self-assembly of a new type of oligosiloxanes. The dispersion of the mesostructures in a nonpolar solvent transforms them into siloxane core/organic shell nanoparticles. Their ability to function as nanocarriers was demonstrated by the in situ encapsulation of fluorescent dyes.

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53_35c/2014Inside Back Cover: Cavitand-Grafted Silicon Microcantilevers as a Universal Probe for Illicit and Designer Drugs in Water (Angew. Chem. Int. Ed. 35/2014)

Opposing the dissemination of designer drugs requires versatile analytical tools capable of addressing their common structural features. In their Communication on page 9183 ff., P. Bergese, E. Dalcanale, et al. report a supramolecular nanomechanical device for the label-free detection of the whole class of methamphetamines in water. The device combines the molecular recognition of a tetraphosphonate cavitand and silicon microcantilevers.

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53_35b/2014Back Cover: Antagonizing STAT3 Dimerization with a Rhodium(III) Complex (Angew. Chem. Int. Ed. 35/2014)

STAT3 dimerization can be directly inhibited by a substitutionally inert, Group 9 organometallic compound, as D.-L. Ma, C.-H. Leung, H.-M. D. Wang, and co-workers report in their Communication on page 9178 ff. The cyclometalated rhodium(III) complex targets the SH2 domain of STAT3 (signal transducer and activator of transcription 3), and exhibits potent anticancer activity against melanoma xenograft in an in vivo mouse model.

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