Angewandte Chemie International Edition

Cover image for Vol. 53 Issue 52

Editor: Peter Gölitz, Deputy Editors: Neville Compton, Haymo Ross

Online ISSN: 1521-3773

Associated Title(s): Angewandte Chemie, Chemistry - A European Journal, Chemistry – An Asian Journal, ChemistryOpen, ChemPlusChem, Zeitschrift für Chemie

53_51/2014Cover Picture: Switchable Amplification of Vibrational Circular Dichroism as a Probe of Local Chiral Structure (Angew. Chem. Int. Ed. 51/2014)

Vibration circular dichroism (VCD) spectroscopy is used to determine the absolute configuration and conformation of chiral molecules in solution but low signal intensities and spectral congestion often prohibit the investigation of local structure. In their Communication on page 14042 ff., F. Hartl, W. J. Buma, S. Woutersen et al. describe the attachment of a ferrocene-based electrochemically switchable amplifier to a molecular system, which enables the local amplification of the VCD signal.

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Also of Interest

Vibration circular dichroism (VCD) spectroscopy is used to determine the absolute configuration and conformation of chiral molecules in solution but low signal intensities and spectral congestion often prohibit the investigation of local structure. In their Communication on page 14042 ff., F. Hartl, W. J. Buma, S. Woutersen et al. describe the attachment of a ferrocene-based electrochemically switchable amplifier to a molecular system, which enables the local amplification of the VCD signal.

Surface Analysisfor001

N. M. Markovic et al. describe in their Communication on page 14016 ff. how the activity of bimetallic oxide materials for the oxygen evolution reaction can be tuned through surface segregation of the elements into nanosegregated domains.


Mass Spectrometryfor002

A highly sensitivity single-step method based on slug-flow microextraction for the mass spectrometric analysis of organic compounds in only 5 μL of a biofluid is described by Z. Ouyang and co-workers in their Communication on page 14124 ff.


Enzyme Catalysisfor003

The preparation of a nylon-6 monomer, 6-aminohexanoic acid, from cyclohexanol at the expense of only NH3 and O2 by using two biocatalytic self-sufficient redox modules is described by W. Kroutil et al. in their Communication on page 14153 ff.


53_51i/2014Inside Cover: Dynamic Photocontrol of the Coffee-Ring Effect with Optically Tunable Particle Stickiness (Angew. Chem. Int. Ed. 51/2014)

The coffee-ring effect denotes the accumulation of particles at the edge of an evaporating sessile drop. In their Communication on page 14077 ff., M. Anyfantakis and D. Baigl demonstrate the first dynamic photocontrol of this ubiquitous phenomenon. By optically tuning the particle stickiness on demand, it is possible to remotely direct particle deposition into a wide range of patterns from rings to homogeneous disks in a photoreversible manner.

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53_51c/2014Inside Back Cover: Direct Mass Spectrometry Analysis of Biofluid Samples Using Slug-Flow Microextraction Nano-Electrospray Ionization (Angew. Chem. Int. Ed. 51/2014)

Two immiscible liquid plugs of several microliters moving inside a capillary induce circulating flows in each plug that facilitate efficient extraction at the liquid–liquid interface. In their Communication on page 14124 ff., Z. Ouyang and co-workers present a direct, quantitative mass spectrometric method based on this slug-flow microextraction for analysis of biomarkers in 5 μL samples of biofluids. Real-time monitoring of the enzymatic functions of blood samples can also be performed.

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53_51b/2014Back Cover: Introducing an In Situ Capping Strategy in Systems Biocatalysis To Access 6-Aminohexanoic acid (Angew. Chem. Int. Ed. 51/2014)

The one-pot synthesis of a nylon-6 monomer by a combination of two redox self-sufficient biocatalytic modules (gray box and flask) is described by W. Kroutil et al. in their Communication on page 14153 ff. The cascade is shown as an electric circuit, whereby each enzyme is shown at a crossing and an in situ capping strategy prevents dead-end inhibition by an intermediate. The proof of principle was shown by the synthesis of 6-aminohexanoic acid starting from cyclohexanol only at the expense of NH3 and O2. The graphic was designed by Verena Andrea Resch

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