Angewandte Chemie International Edition

Cover image for Vol. 54 Issue 18

Editor: Peter Gölitz, Deputy Editors: Neville Compton, Haymo Ross

Online ISSN: 1521-3773

Associated Title(s): Angewandte Chemie, Chemistry - A European Journal, Chemistry – An Asian Journal, ChemistryOpen, ChemPlusChem, Zeitschrift für Chemie

54_18/2015Cover Picture: Intracellular Modulation of Excited-State Dynamics in a Chromophore Dyad: Differential Enhancement of Photocytotoxicity Targeting Cancer Cells (Angew. Chem. Int. Ed. 18/2015)

Orthogonal BODIPY dimers offer exciting potential as activatable photosensitizers for photodynamic therapy. In their Communication on page 5340 ff., J. Yoon, E. U. Akkaya et al. report a photosensitizer that is switched on by a reaction with glutathione (GSH). Comparative cell culture data show that the agent is preferentially activated in cancer cells as they feature a higher glutathione level than normal cells.

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Also of Interest

Orthogonal BODIPY dimers offer exciting potential as activatable photosensitizers for photodynamic therapy. In their Communication on page 5340 ff., J. Yoon, E. U. Akkaya et al. report a photosensitizer that is switched on by a reaction with glutathione (GSH). Comparative cell culture data show that the agent is preferentially activated in cancer cells as they feature a higher glutathione level than normal cells.

Alloysfor001

In their Communication on page 5312 ff., M. Saeys,. A. N. Alexandrova, et al. present a chemical bonding model to explain the special stability and the reconstruction of surface cobalt and nickel carbides containing square-planar carbon atoms.


Titanacyclesfor002

U. Rosenthal et al. describe the formation of macrocycles from dinitriles and titanocenes in their Communication on page 5523 ff. The products are sometimes not stable and very difficult to characterize.


Helicenesfor003

The synthesis of double N-hetero[5]helicenes that consist of two nitrogen-substituted heteropentacenes by tandem oxidative C-N couplings is described by D. Sakamaki, S. Seki, et al. in their Communication on page 5404 ff.


54_18i/2015Inside Cover: Reversible 1,1-Hydroboration: Boryl Insertion into a C-N Bond and Competitive Elimination of HBR2 or R-H (Angew. Chem. Int. Ed. 18/2015)

N-heterocyclic molecules undergo an unprecedented 1,1-hydroboration with a variety of boranes (HBR2) to form new BN heterocycles that undergo two competitive thermal-elimination pathways: retro-1,1-hydroboration or R-H elimination. As S. Wang et al. show in their Communication on page 5498 ff., the elimination pathway is an efficient method for providing highly emissive BN-doped arenes. The cover art was designed and painted by Yufei Li, a Ph.D. student at Queen's University.

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54_18c/2015Inside Back Cover: Formation of Tri- and Tetranuclear Titanacycles through Decamethyltitanocene-Mediated Intermolecular C–C Coupling of Dinitriles (Angew. Chem. Int. Ed. 18/2015)

Reactions of dinitriles with titanocenes lead to the formation of macrocycles through nitrile–nitrile C-C couplings. In their Communication on page 5523 ff., U. Rosenthal and co-workers also show, that these macrocycles are sometimes not stable and very difficult to characterize ("pain and pleasure” of conducting research symbolized by the titan Atlas, who is holding a macrocycle). The sky in the background shows the logo of the Leibniz Institute for Catalysis, which supported this work.

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54_18b/2015Back Cover: A Facile and Versatile Approach to Double N-Heterohelicenes: Tandem Oxidative C-N Couplings of N-Heteroacenes via Cruciform Dimers (Angew. Chem. Int. Ed. 18/2015)

Double N-hetero[5]helicenes that consist of two nitrogen-substituted heteropentacenes were synthesized by tandem oxidative C-N couplings via the cruciform dimers. In their Communication on page 5404 ff., D. Sakamaki, S. Seki, and co-workers describe the synthesis, structures, and electronic properties of these novel compounds, which are remarkably stable toward racemization.

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