Angewandte Chemie International Edition

Cover image for Vol. 53 Issue 49

Editor: Peter Gölitz, Deputy Editors: Neville Compton, Haymo Ross

Online ISSN: 1521-3773

Associated Title(s): Angewandte Chemie, Chemistry - A European Journal, Chemistry – An Asian Journal, ChemistryOpen, ChemPlusChem, Zeitschrift für Chemie

53_49/2014Cover Picture: Biosynthesis of the Halogenated Mycotoxin Aspirochlorine in Koji Mold Involves a Cryptic Amino Acid Conversion (Angew. Chem. Int. Ed. 49/2014)

The Koji Mold Aspergillus oryzae, which is widely used in food fermentations (e.g., sake production), produces the toxin aspirochlorine. C. Hertweck et al. elucidated in their Communication on page 13409 ff. the biosynthetic pathway of this chlorinated epipolythiodioxopiperazine. An iterative non-ribosomal peptide synthetase assembles the diketopiperazine core from two phenylalanine units, one of which then undergoes an unprecedented conversion to glycine. Enzymatic halogenation of the second Phe unit significantly contributes to the biological activity of aspirochlorine.

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Also of Interest

The Koji Mold Aspergillus oryzae, which is widely used in food fermentations (e.g., sake production), produces the toxin aspirochlorine. C. Hertweck et al. elucidated in their Communication on page 13409 ff. the biosynthetic pathway of this chlorinated epipolythiodioxopiperazine. An iterative non-ribosomal peptide synthetase assembles the diketopiperazine core from two phenylalanine units, one of which then undergoes an unprecedented conversion to glycine. Enzymatic halogenation of the second Phe unit significantly contributes to the biological activity of aspirochlorine.

Adhesive Proteinsfor001

Mussel glue with a very high Dopa content was engineered through residue-specific Dopa incorporation in Escherichia coli, as described by H. J. Cha et al. in their Communication on page 13360 ff. The bioglue exhibits strong adhesion and water-resistance.


Single-Molecule Magnetsfor002

In their Communication on page 13434 ff., M. Mazzanti et al. report a trinuclear {Mn-O=U=O-Mn} complex that behaves as a single-molecule magnet with the highest effective relaxation barrier (81±0.5 K) for a mono-uranium system.


Lithium-Ion Batteriesfor003

The aspect ratio of the nanostructures used to fabricate electrode materials correlates with the electrochemical performance in lithium-ion batteries. The findings of Z. Chen, X. Chen, et al. in their Communication on page 13488 ff. may lead to efficient devices based on nanomaterials.


53_49i/2014Inside Cover: Polyoxometalate Ionic Liquids as Self-Repairing Acid-Resistant Corrosion Protection (Angew. Chem. Int. Ed. 49/2014)

Self-healing corrosion protection is provided by functional polyoxometalate ionic liquids (POM-ILs) coated onto metal surfaces. In their Communication on page 13596 ff., C. Streb et al. utilize POM-ILs, which are hydrophobic, acid-resistant, and form mechanically stable films, to protect copper metal against acid corrosion. Mechanical damage to the coating is self-repaired in less than one minute through the unique rheological properties of the compounds.

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53_49c/2014Inside Back Cover: Self-Assembly of a 3d–5f Trinuclear Single-Molecule Magnet from a Pentavalent Uranyl Complex (Angew. Chem. Int. Ed. 49/2014)

A uranyl(V) complex is used as a building block in the rational assembly of a trinuclear {Mn-O=U=O-Mn} complex. M. Mazzanti and co-workers demonstrate in their Communication on page 13434 ff. that the trinuclear system exhibits the behavior of a single-molecule magnet with the highest effective barrier to relaxation reported to date for a mono-uranium system (ΔE=(81±0.5) K), resulting from the large Ising anisotropy of the uranyl-based bridge and intramolecular Mn–U exchange interactions.

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53_49b/2014Back Cover: Unravelling the Correlation between the Aspect Ratio of Nanotubular Structures and Their Electrochemical Performance To Achieve High-Rate and Long-Life Lithium-Ion Batteries (Angew. Chem. Int. Ed. 49/2014)

Understanding the relationship between the nanostructure of an electrode and its electrochemical performance is crucial for the development of high-perfomance lithium-ion batteries. In their Communication on page 13488 ff., Z. Chen, X. Chen, and co-workers report that the aspect ratio of nanotubular materials determines battery performance at high charging/discharging rates. Their proof-of-concept batteries are very promising for energy-storage systems in electrical vehicles.

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