Angewandte Chemie International Edition

Cover image for Vol. 53 Issue 31

Editor: Peter Gölitz, Deputy Editors: Neville Compton, Haymo Ross

Online ISSN: 1521-3773

Associated Title(s): Angewandte Chemie, Chemistry - A European Journal, Chemistry – An Asian Journal, Zeitschrift für Chemie

53_31/2014Cover Picture: Protein Interactions with Polymer Coatings and Biomaterials (Angew. Chem. Int. Ed. 31/2014)

Polymeric material coatings such as Teflon and hydrophilic polymer surfaces can prevent protein adhesion to generate protein-resistant surfaces. The Review by R. Haag et al. on page 8004 ff. describes methods and recent advances in the field of protein interactions on polymeric materials. The cover picture illustrates the adsorption of proteins (egg white) to material surfaces as exemplified by the egg in the pan. (Graphic designed by Achim Wiedekind with a background picture by Ruben Haag.)

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Also of Interest

Polymeric material coatings such as Teflon and hydrophilic polymer surfaces can prevent protein adhesion to generate protein-resistant surfaces. The Review by R. Haag et al. on page 8004 ff. describes methods and recent advances in the field of protein interactions on polymeric materials. The cover picture illustrates the adsorption of proteins (egg white) to material surfaces as exemplified by the egg in the pan. (Graphic designed by Achim Wiedekind with a background picture by Ruben Haag.)

Hydrogen Bondsfor001

In his Communication on page 8032 ff., T. Ohba describes the anomalous structure of water in carbon nanotubes. In nanotubes with diameters of 2 and 3 nm, water forms clusters because of prolific hydrogen bonding.


DNA Origami Nanostructuresfor002

In their Communication on page 8137 ff., M. Endo, H. Sugiyama, H. Mao et al. report DNA origami nanostructures that were used as expanded platforms for multiplex mechanochemical sensing.


Prebiotic Chemistryfor003

From an analysis of archived samples from Stanley Miller's previously unreported 1958 cyanamide experiment, F. M. Fernández, J. L. Bada et al. show in their Communication on page 8132 ff. that cyanamide enhances amino acid polymerization under prebiotic conditions.


53_31i/2014Inside Cover: Tuning the Composition of AuPt Bimetallic Nanoparticles for Antibacterial Application (Angew. Chem. Int. Ed. 31/2014)

Some metals such as Ag and Hg are well known to have intrinsic antibacterial properties, but these metals are also toxic. X. Jiang and co-workers report a new class of nontoxic AuPt bimetallic nanoparticles with potent antibacterial properties in their Communication on page 8127 ff. The antibiotic mechanism includes the rupture of the inner bacterial membrane and an increase in intracellular adenosine triphosphate (ATP) levels, but does not involve the generation of reactive oxygen species.

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53_31c/2014Inside Back Cover: Single-Molecule Mechanochemical Sensing Using DNA Origami Nanostructures (Angew. Chem. Int. Ed. 31/2014)

DNA origami nanotiles have been used as novel multiplex mechanochemical sensors. In their Communication on page 8137 ff., M. Endo, H. Sugiyama, H. Mao et al. show that the binding of specific target molecules to the sensor unlocks the interconnected tiles, and the global topology of the DNA nanostructure rearranges. This process is monitored as mechanochemical signals in real time using optical tweezers.

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53_31b/2014Back Cover: A Plausible Simultaneous Synthesis of Amino Acids and Simple Peptides on the Primordial Earth (Angew. Chem. Int. Ed. 31/2014)

Stanley Miller's cyanamide experiment went unreported for over 50 years, but was recently explored to study cyanamide-mediated biomolecule polymerization under early Earth conditions. In their Communication on page 8132 ff., F. M. Fernández, J. L. Bada et al. show that the dimerization of cyanamide in the presence of amino acids and intermediates in the Strecker synthesis of amino acids yields significant levels of dipeptides, which provides evidence that cyanamide enhances polymerization under simulated prebiotic environments. (Background image provided by Ron Miller.)

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