Angewandte Chemie International Edition

Cover image for Vol. 53 Issue 17

Editor: Peter Gölitz, Deputy Editors: Neville Compton, Haymo Ross

Online ISSN: 1521-3773

Associated Title(s): Angewandte Chemie, Chemistry - A European Journal, Chemistry – An Asian Journal, Zeitschrift für Chemie

53_17/2014Cover Picture: Short Chemoenzymatic Total Synthesis of ent-Hydromorphone: An Oxidative Dearomatization/Intramolecular [4+2] Cycloaddition/Amination Sequence (Angew. Chem. Int. Ed. 17/2014)

A 12-step chemoenzymatic total synthesisof ent-hydromorphone from β-bromoethylbenzene is described by T. Hudlicky and V. Varghese in their Communication on page 4355 ff. The key steps consist of enzymatic dihydroxylation, Mitsunobu coupling, and oxidative dearomatization followed by intramolecular [4+2] cycloaddition. This approach holds potential for further optimization of morphine alkaloid syntheses. We acknowledge the legendary efforts of the chemists pictured, who dedicated their careers to the chemistry of morphine. Cover design: Dennis Ceci, Tomas Hudlicky, Jordan Froese (Brock University).

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Also of Interest

A 12-step chemoenzymatic total synthesisof ent-hydromorphone from β-bromoethylbenzene is described by T. Hudlicky and V. Varghese in their Communication on page 4355 ff. The key steps consist of enzymatic dihydroxylation, Mitsunobu coupling, and oxidative dearomatization followed by intramolecular [4+2] cycloaddition. This approach holds potential for further optimization of morphine alkaloid syntheses. We acknowledge the legendary efforts of the chemists pictured, who dedicated their careers to the chemistry of morphine. Cover design: Dennis Ceci, Tomas Hudlicky, Jordan Froese (Brock University).

Solid-State NMR Spectroscopyfor001

In their Communication on page 4312 ff., P. Schanda et al. describe an NMR method used to probe conformational states of proteins. Information about the exchange kinetics, relative populations, and structures of the short-lived state can be obtained.


Natural Product Synthesisfor002

M. Wilsdorf and H.-U. Reissig describe a convergent total synthesis of (±)-γ-rubromycin in their Communication on page 4332 ff. Three highly functionalized building blocks are combined through selective organometallic chemistry.


Functional Polymer Layersfor003

In their Communication on page 4465 ff., Y. Wang et al. report functional polymer layers on paper. Near-infrared light was used to change the conductivity and wettability of the polymers.


53_17i/2014Inside Cover: Identification and X-ray Co-crystal Structure of a Small-Molecule Activator of LFA-1-ICAM-1 Binding (Angew. Chem. Int. Ed. 17/2014)

The immune response regulating the protein–protein interaction of the integrin leucocyte function associated antigen 1 and intercellular adhesion molecule 1 is allosterically enhanced by the binding of IBE-667 to a remote site on LFA-1. M. Hintersteiner, M. Auer, and co-workers show in their Communication on page 4322 ff. that the identification of IBE-667 can be achieved through a combinatorial library screening approach with several techniques.

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53_17c/2014Inside Back Cover: A Convergent Total Synthesis of the Telomerase Inhibitor (±)-γ-Rubromycin (Angew. Chem. Int. Ed. 17/2014)

Silicon in, silicon out could be the caption for the convergent total synthesis of the telomerase inhibitor (±)-γ-rubromycin reported by M. Wilsdorf and H.-U. Reissig in their Communication on page 4332 ff. They combine three highly functionalized building blocks through selective organometallic chemistry and a silyl-substituted C3 building block plays a key role. Three acid-promoted reactions serve to generate the sensitive spiroketal natural product under desilylation. Graphic courtesy of Dr. Daniel Trawney.

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53_17b/2014Back Cover: A Photo-annealing Approach for Building Functional Polymer Layers on Paper (Angew. Chem. Int. Ed. 17/2014)

A photo-annealing approach was developed for building functional polymer layers on paper. In their Communication on page 4465 ff., Y. Wang and co-workers show that conducting polyaniline with the ability to undergo photothermal conversion can be annealed by near-infrared light. The porous structure is retained in the annealed polymer but it becomes insulating and hydrophobic. The asymmetric paper functions as a “water diode” and selective photo-annealing produces patterned conductive arrays.

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