Angewandte Chemie International Edition
Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
February 19, 2013
VIP: Chiral Magnesium(II) Binaphtholates as Cooperative Brønsted/Lewis Acid–Base Catalysts for Highly Enantioselective Addition of Phosphorus Nucleophiles to α,β-Unsaturated Esters and Ketones
Manabu Hatano, Takahiro Horibe, and Kazuaki Ishihara*
Highly enantioselective 1,4-hydrophosphinylation of α,β-unsaturated esters with diarylphosphine oxides and 1,2-hydrophosphonylation of α,β-unsaturated ketones with dialkyl phosphites were developed with the use of simple and practical chiral magnesium(II) binaphtholate aqua complexes as cooperative Brønsted/Lewis acid–base supramolecular catalysts in situ.
Received February 02, 2013, published online March 13, 2013, DOI: 10.1002/anie.201300938 – read now. No. 17/2013.
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