Angewandte Chemie International Edition

Cover image for Vol. 54 Issue 14

Editor: Peter Gölitz, Deputy Editors: Neville Compton, Haymo Ross

Online ISSN: 1521-3773

Associated Title(s): Angewandte Chemie, Chemistry - A European Journal, Chemistry – An Asian Journal, ChemistryOpen, ChemPlusChem, Zeitschrift für Chemie

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March 26, 2015

Hot Paper: Multifunctional Reagents for Quantitative Proteome-Wide Analysis of Protein Modification in Human Cells and Dynamic Profiling of Protein Lipidation During Vertebrate Development

Dr. Malgorzata Broncel, Dr. Remigiusz A. Serwa, Paulina Ciepla, Dr. Eberhard Krause, Prof. Margaret J. Dallman, Prof. Anthony I. Magee and Prof. Edward W. Tate

Multifunctional Reagents for Quantitative Proteome-Wide Analysis of Protein Modification in Human Cells and Dynamic Profiling of Protein Lipidation During Vertebrate DevelopmentCatch and release: Multifunctional capture reagents were developed that enable enzymatically-triggered release and direct detection of lipid-modified peptides by mass spectrometry. Dynamic proteome lipidation was visualized, enriched, and identified on an unprecedented scale, both in cells and in a developing zebrafish embryo.

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March 26, 2015

Hot Paper: Formation of BN Isosteres of Azo Dyes by Ring Expansion of Boroles with Azides

Prof. Dr. Holger Braunschweig, Dr. Mehmet Ali Celik, Florian Hupp, Dr. Ivo Krummenacher and Lisa Mailänder

Formation of BN Isosteres of Azo Dyes by Ring Expansion of Boroles with AzidesAzo borealis: The first 1,2-azaborinine-substituted azo dyes have been synthesized using sterically demanding boroles and organic azides. The ring-expansion mechanism of the unexpected formation of the bright yellow chromophores was investigated by DFT calculations.

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March 26, 2015

VIP: Structural Transformation: Assembly of an Otherwise Inaccessible DNA Nanocage

Dr. Yulin Li, Dr. Cheng Tian, Zhiyu Liu, Prof. Wen Jiang and Prof. Chengde Mao

Structural Transformation: Assembly of an Otherwise Inaccessible DNA NanocageOne way or another: A strategy has been developed for the assembly of DNA nanocages that can not be assembled directly. In this approach a precursor DNA nanocage is assembled first and is then isothermally transformed into a desired, complicated nanocage. Dramatic changes in the 3D structures and topologies accompany the transformation, as shown by native polyacrylamide gel electrophoresis and cryogenic electron microscopy imaging.

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March 26, 2015

VIP: Secondary Crystal Nucleation: Nuclei Breeding Factory Uncovered

Prof. Jamshed Anwar, Dr. Shahzeb Khan and Prof. Dr. Lennart Lindfors

Secondary Crystal Nucleation: Nuclei Breeding Factory UncoveredCrystal clear: Molecular dynamics simulations uncover the nuclei breeding factory responsible for secondary nucleation in crystal growth. The question why a few crystal seeds give rise to a many-fold increase in new crystals is answered. This mechanistic insight will enable better control in engineering crystalline products to design.

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March 25, 2015

Hot Paper: Intracellular Modulation of Excited-State Dynamics in a Chromophore Dyad: Differential Enhancement of Photocytotoxicity Targeting Cancer Cells

Dr. Safacan Kolemen, Dr. Murat Işık, Gyoung Mi Kim, Dabin Kim, Hao Geng, Muhammed Buyuktemiz, Tugce Karatas, Prof. Xian-Fu Zhang, Prof. Yavuz Dede, Prof. Juyoung Yoon and Prof. Engin U. Akkaya

Intracellular Modulation of Excited-State Dynamics in a Chromophore Dyad: Differential Enhancement of Photocytotoxicity Targeting Cancer CellsSelective switch: A dimeric BODIPY dye with reduced symmetry is ineffective as a photosensitizer unless it is activated by a reaction with intracellular glutathione (GSH). Staining with red-fluorescent Annexin V shows that the photosensitizer is preferentially switched on in cancer cells, which feature a higher GSH level than normal cells.

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March 25, 2015

VIP: Origin of Extraordinary Stability of Square-Planar Carbon Atoms in Surface Carbides of Cobalt and Nickel

Anjan Nandula, Quang Thang Trinh, Prof. Mark Saeys and Prof. Anastassia N. Alexandrova

Origin of Extraordinary Stability of Square-Planar Carbon Atoms in Surface Carbides of Cobalt and NickelOut for the count: The unusual stability and reconstruction of surface cobalt and nickel carbides containing square-planar carbon atoms is explained by local aromaticity and electron count. A chemical bonding model for these systems is presented and explains the unusual structure, special stability, and the reconstruction. Several new aromatic and stable two-dimensional alloys are predicted.

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March 25, 2015

VIP: A Unique Fluoride Nanocontainer: Porous Molecular Capsules Can Accommodate an Unusually High Number of “Rather Labile” Fluoride Anions

Somenath Garai, Dr. Mirta Rubčić, Dr. Hartmut Bögge, Dr. Erhard T. K. Haupt, Prof. Dr. Pierre Gouzerh and Prof. Dr. Achim Müller

A Unique Fluoride Nanocontainer: Porous Molecular Capsules Can Accommodate an Unusually High Number of “Rather Labile” Fluoride AnionsOverloaded: Porous molecular nanocontainers of the {Mo132} Keplerate type can integrate a uniquely large number of fluorides. These F ions (see structure, green) are partly as coordinated ligands at both the {(MoVI)MoVI5O21(H2O)5(F)} pentagonal units (orange) and the linkers (blue), partly as a disordered water/fluoride assembly inside the cavity. The H2O ligands are shown as red spheres (larger red spheres are for H2O coordinated e.g. to the MoV centers of the linkers).

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March 21, 2015

Hot Paper: Widening Synthesis Bottlenecks: Realization of Ultrafast and Continuous-Flow Synthesis of High-Silica Zeolite SSZ-13 for NOx Removal

Zhendong Liu, Prof. Dr. Toru Wakihara, Dr. Kazunori Oshima, Daisuke Nishioka, Yuusuke Hotta, Dr. Shanmugam P. Elangovan, Yutaka Yanaba, Prof. Dr. Takeshi Yoshikawa, Dr. Watcharop Chaikittisilp, Takeshi Matsuo, Takahiko Takewaki and Prof. Dr. Tatsuya Okubo

Widening Synthesis Bottlenecks: Realization of Ultrafast and Continuous-Flow Synthesis of High-Silica Zeolite SSZ-13 for NOx RemovalBottle opener: SSZ-13 is a zeolite commercialized as a catalyst to remove nitrogen oxides (NOx). However, its long synthesis time is one of the biggest barriers to large-scale production. An ultrafast synthesis route now allows SSZ-13 to be synthesized in 10 min and thus facilitates continuous preparation of SSZ-13. The fast-synthesized SSZ-13 exhibits outstanding performance for the NOx removal.

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March 21, 2015

Hot Paper: Controlling the Origins of Inflammation with a Photoactive Lipopeptide Immunopotentiator

Dr. Rock J. Mancini, Lalisa Stutts, Dr. Troy Moore and Prof. Aaron P. Esser-Kahn

Controlling the Origins of Inflammation with a Photoactive Lipopeptide ImmunopotentiatorThe origin of inflammation in cell culture is commonly obscured by paracrine and autocrine signaling. A small-molecule immunopotentiator was developed that tags cells and initiates inflammation of the tagged cells using light. BMDCs=bone-marrow-derived dendritic cells, TNF=tumor necrosis factor.

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March 21, 2015

Hot Paper: Strained Cyclooctyne as a Molecular Platform for Construction of Multimodal Imaging Probes

Yao Sun, Dr. Xiaowei Ma, Kai Cheng, Biying Wu, Jianli Duan, Hao Chen, Lihong Bu, Ruiping Zhang, Prof. Xianming Hu, Zixin Deng, Lei Xing, Xuechuan Hong and Prof. Zhen Cheng

Strained Cyclooctyne as a Molecular Platform for Construction of Multimodal Imaging ProbesSpitting image: The products of the base-catalyzed addition of various functional molecules to bicyclo[6.1.0]nonyne-based scaffolds provided precursors for novel dual-modality (PET and NIRF) uPAR-targeted imaging probes. The probes were evaluated in U87MG cells and tumor-bearing mice models, thus demonstrating excellent imaging characteristics.

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March 21, 2015

VIP: A Constellation of Deuterium-Labeled Silanes as a Simple Mechanistic Probe not Requiring Absolute Configuration Determination

Dr. Thomas Fallon and Prof. Dr. Martin Oestreich

A Constellation of Deuterium-Labeled Silanes as a Simple Mechanistic Probe not Requiring Absolute Configuration DeterminationSilicon stargazing: A new type of mechanistic probe is designed and evaluated. A cocktail of deuterium-labeled hydrosilanes provides a “silent” stereochemical relationship between the silicon atom and the probe’s backbone as the basis of the analysis. This technique does not suffer from the biases of traditional methods, nor does it require the determination of the absolute configuration.

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March 18, 2015

Hot Paper: Bioorthogonal Deprotection on the Dendritic Cell Surface for Chemical Control of Antigen Cross-Presentation

Joanna B. Pawlak, Geoffroy P. P. Gential, Dr. Tracy J. Ruckwardt, Jessica S. Bremmers, Nico J. Meeuwenoord, Prof. Ferry A. Ossendorp, Prof. Herman S. Overkleeft, Dr. Dmitri V. Filippov and Dr. Sander I. van Kasteren

Bioorthogonal Deprotection on the Dendritic Cell Surface for Chemical Control of Antigen Cross-PresentationAntigen cross-presentation is the uptake of exogenous antigens followed by processing in the MHC-I complex, which is normally reserved for endogenous antigens. This process may now be studied by using masked epitopes: Azides are exploited as bioorthogonal protecting groups to generate antigens that are not recognized by their cognate T-cell unless they are deprotected using an on-cell Staudinger reduction.

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March 26, 2015
Hot Paper: Multifunctional Reagents for Quantitative Proteome-Wide Analysis of Protein Modification in Human Cells and Dynamic Profiling of Protein Lipidation During Vertebrate Development

March 26, 2015
Hot Paper: Formation of BN Isosteres of Azo Dyes by Ring Expansion of Boroles with Azides

March 26, 2015
VIP: Structural Transformation: Assembly of an Otherwise Inaccessible DNA Nanocage

March 26, 2015
VIP: Secondary Crystal Nucleation: Nuclei Breeding Factory Uncovered

March 25, 2015
Hot Paper: Intracellular Modulation of Excited-State Dynamics in a Chromophore Dyad: Differential Enhancement of Photocytotoxicity Targeting Cancer Cells

March 25, 2015
VIP: Origin of Extraordinary Stability of Square-Planar Carbon Atoms in Surface Carbides of Cobalt and Nickel

March 25, 2015
VIP: A Unique Fluoride Nanocontainer: Porous Molecular Capsules Can Accommodate an Unusually High Number of “Rather Labile” Fluoride Anions

March 21, 2015
Hot Paper: Widening Synthesis Bottlenecks: Realization of Ultrafast and Continuous-Flow Synthesis of High-Silica Zeolite SSZ-13 for NOx Removal

March 21, 2015
Hot Paper: Controlling the Origins of Inflammation with a Photoactive Lipopeptide Immunopotentiator

March 21, 2015
Hot Paper: Strained Cyclooctyne as a Molecular Platform for Construction of Multimodal Imaging Probes

March 21, 2015
VIP: A Constellation of Deuterium-Labeled Silanes as a Simple Mechanistic Probe not Requiring Absolute Configuration Determination

March 18, 2015
Hot Paper: Bioorthogonal Deprotection on the Dendritic Cell Surface for Chemical Control of Antigen Cross-Presentation

March 18, 2015
Hot Paper: Heterogeneously Catalyzed Direct C[BOND]H Thiolation of Heteroarenes

March 18, 2015
Hot Paper: Macromolecular Surface Design: Photopatterning of Functional Stable Nitrile Oxides

March 18, 2015
VIP: Improving the Electrochemical Performance of the Li4Ti5O12 Electrode in a Rechargeable Magnesium Battery by Lithium–Magnesium Co-Intercalation

March 18, 2015
VIP: Direct C(sp2)[BOND]C(sp3) Cross-Coupling of Diaryl Zinc Reagents with Benzylic, Primary, Secondary, and Tertiary Alkyl Halides

March 17, 2015
Angewandte Chemie 13/2015: Catalysis and More

March 17, 2015
Hot Paper: A Promiscuous De Novo Retro-Aldolase Catalyzes Asymmetric Michael Additions via Schiff Base Intermediates

March 17, 2015
Hot Paper: Self-Template-Directed Synthesis of Porous Perovskite Nanowires at Room Temperature for High-Performance Visible-Light Photodetectors

March 13, 2015
VIP: High Ethene/Ethane Selectivity in 2,2′-Bipyridine-Based Silver(I) Complexes by Removal of Coordinated Solvent

March 12, 2015
VIP: A Facile and Universal Top-Down Method for Preparation of Monodisperse Transition-Metal Dichalcogenide Nanodots

March 11, 2015
Angewandte Chemie 12/2015: Traffic Control

March 10, 2015
Hot Paper: Iridium-Catalyzed Reductive Carbon–Carbon Bond Cleavage Reaction on a Curved Pyridylcorannulene Skeleton

March 10, 2015
Hot Paper: A FRET Probe for Cell-Based Imaging of Ganglioside-Processing Enzyme Activity and High-Throughput Screening

March 10, 2015
VIP: Solvated Graphene Frameworks as High-Performance Anodes for Lithium-Ion Batteries

March 06, 2015
VIP: Direct Observation of Ca2+-Induced Calmodulin Conformational Transitions in Intact Xenopus laevis Oocytes by 19F NMR Spectroscopy

March 05, 2015
VIP: One-Step Synthesis of a [20]Silafullerane with an Endohedral Chloride Ion

March 04, 2015
Angewandte Chemie 11/2015: 150 Years of BASF

March 04, 2015
Hot Paper: Targeted Fluorination with the Fluoride Ion by Manganese-Catalyzed Decarboxylation

March 04, 2015
Hot Paper: Polymersomes Prepared from Thermoresponsive Fluorescent Protein–Polymer Bioconjugates: Capture of and Report on Drug and Protein Payloads

March 04, 2015
Hot Paper: Ruthenium(II)-Catalyzed C[BOND]H Activation/Alkyne Annulation by Weak Coordination with O2 as the Sole Oxidant

March 03, 2015
Hot Paper: Polymeric Micelle Assembly with Inorganic Nanosheets for Construction of Mesoporous Architectures with Crystallized Walls

March 03, 2015
Hot Paper: Photoinduced Postsynthetic Polymerization of a Metal–Organic Framework toward a Flexible Stand-Alone Membrane

February 28, 2015
Hot Paper: Cooperative Bond Activation and Catalytic Reduction of Carbon Dioxide at a Group 13 Metal Center

February 28, 2015
VIP: On the Role of the Electronic Structure of the Heteronuclear Oxide Cluster [Ga2Mg2O5].+ in the Thermal Activation of Methane and Ethane: An Unusual Doping Effect

February 27, 2015
Hot Paper: Lewis Acid Promoted Ruthenium(II)-Catalyzed Etherifications by Selective Hydrogenation of Carboxylic Acids/Esters

February 27, 2015
VIP: Oxidative Addition of Carbon–Carbon Bonds to Gold

February 26, 2015
VIP: Interrupted Chalcogenide-Based Zeolite-Analog Semiconductor: Atomically Precise Doping for Tunable Electro-/Photoelectrochemical Properties

February 26, 2015
VIP: Well-Defined CuC2F5 Complexes and Pentafluoroethylation of Acid Chlorides

February 26, 2015
VIP: Synthesis of Carbon/Sulfur Nanolaminates by Electrochemical Extraction of Titanium from Ti2SC

February 25, 2015
Hot Paper: Iron-Catalyzed Dehydropolymerization: A Convenient Route to Poly(phosphinoboranes) with Molecular-Weight Control

February 24, 2015
Hot Paper: A Concise and Scalable Strategy for the Total Synthesis of Dictyodendrin B Based on Sequential C[BOND]H Functionalization

February 24, 2015
Hot Paper: Visible-Light-Triggered Molecular Photoswitch Based on Reversible E/Z Isomerization of a 1,2-Dicyanoethene Derivative

February 24, 2015
Hot Paper: (−)-Englerin A is a Potent and Selective Activator of TRPC4 and TRPC5 Calcium Channels

February 24, 2015
Hot Paper: Temperature-Controlled Bidirectional Enantioselectivity in a Dynamic Catalyst for Asymmetric Hydrogenation

February 21, 2015
Hot Paper: Cooperative Catalysis of Noncompatible Catalysts through Compartmentalization: Wacker Oxidation and Enzymatic Reduction in a One-Pot Process in Aqueous Medium

February 21, 2015
VIP: Organoaluminum-Mediated Direct Cross-Coupling Reactions

February 20, 2015
Hot Paper: Electrochemically Mediated Atom Transfer Radical Polymerization from a Substrate Surface Manipulated by Bipolar Electrolysis: Fabrication of Gradient and Patterned Polymer Brushes

February 20, 2015
Hot Paper: Dehydrogenative Homocoupling of Terminal Alkenes on Copper Surfaces: A Route to Dienes

February 20, 2015
VIP: Structural Characterization of a Hydroperoxo Nickel Complex and Its Autoxidation: Mechanism of Interconversion between Peroxo, Superoxo, and Hydroperoxo Species

February 19, 2015
Hot Paper: Control of Stem-Cell Behavior by Fine Tuning the Supramolecular Assemblies of Low-Molecular-Weight Gelators

February 19, 2015
Hot Paper: Iron-Catalyzed Asymmetric Hydrosilylation of 1,1-Disubstituted Alkenes

February 19, 2015
Hot Paper: Hybrid Fibers Made of Molybdenum Disulfide, Reduced Graphene Oxide, and Multi-Walled Carbon Nanotubes for Solid-State, Flexible, Asymmetric Supercapacitors

February 19, 2015
Hot Paper: Fabrication of Condensate Microdrop Self-Propelling Porous Films of Cerium Oxide Nanoparticles on Copper Surfaces

February 19, 2015
VIP: A Covalent Approach for Site-Specific RNA Labeling in Mammalian Cells

February 19, 2015
VIP: Free-Standing Gold-Nanoparticle Monolayer Film Fabricated by Protein Self-Assembly of α-Synuclein

February 17, 2015
Hot Paper: Spatially Resolved Quantification of Gadolinium(III)-Based Magnetic Resonance Agents in Tissue by MALDI Imaging Mass Spectrometry after In Vivo MRI

February 17, 2015
VIP: Flow-Enabled Self-Assembly of Large-Scale Aligned Nanowires

February 17, 2015
VIP: Dipolar Rotors Orderly Aligned in Mesoporous Fluorinated Organosilica Architectures

February 13, 2015
Hot Paper: Hypercrosslinked Phenolic Polymers with Well-Developed Mesoporous Frameworks

February 13, 2015
Hot Paper: The Nucleoside Uridine Isolated in the Gas Phase

February 13, 2015
VIP: Caterpillar Track Complexes in Template-Directed Synthesis and Correlated Molecular Motion

February 13, 2015
VIP: Impact of Hydrogenolysis on the Selectivity of the Fischer–Tropsch Synthesis: Diesel Fuel Production over Mesoporous Zeolite Y-Supported Cobalt Nanoparticles

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