Angewandte Chemie International Edition

Cover image for Vol. 53 Issue 39

Editor: Peter Gölitz, Deputy Editors: Neville Compton, Haymo Ross

Online ISSN: 1521-3773

Associated Title(s): Angewandte Chemie, Chemistry - A European Journal, Chemistry – An Asian Journal, ChemistryOpen, ChemPlusChem, Zeitschrift für Chemie

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September 17, 2014

Angewandte Chemie 39/2014: Chemical Logic

Angewandte Chemie 39/2014: Chemical LogicIn this issue, V. Dötsch et al. review in-cell NMR and EPR spectroscopy of biomacromolecules. How did these techniques enable direct investigation of the conformation, dynamics, binding events, and posttranslational modifications of such molecules in living cells? M. Hellwig and T. Henle contribute a short history of the Maillard reaction. What is the chemistry of the aroma, taste, and appearance of thermally processed food? In a Minireview, T. Ube and T. Ikeda summarize the design, fabrication, and function of photomobile polymer materials based on crosslinked liquid-crystalline structures. The Highlight deals with graphene oxide for separation membranes (Z. P. Smith and B. D. Freeman). In their Editorial, H. M. L. Davies and D. Morton explain how collaborative methods redefine the chemical logic of C–H functionalization.

In the Communications section, Z.-Y. Xu et al. present a mild and versatile nitrate-promoted C–H bond fluorination (see picture). H. Tanaka et al. tested their anode catalysts for hydrazine fuel cells in a vehicle prototype, and S. I. Zones et al. succeeded in the preparation of high-silica zeolites with extra-large-pore channels.

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September 16, 2014

VIP: De Novo 3D Structure Determination from Sub-milligram Protein Samples by Solid-State 100 kHz MAS NMR Spectroscopy

Dr. Vipin Agarwal, Susanne Penzel, Kathrin Szekely, Riccardo Cadalbert, Emilie Testori, Andres Oss, Jaan Past, Prof. Ago Samoson, Prof. Matthias Ernst, Dr. Anja Böckmann and Prof. Beat H. Meier

De Novo 3D Structure Determination from Sub-milligram Protein Samples by Solid-State 100 kHz MAS NMR SpectroscopySmaller and faster: The 3D structure of a model protein was determined with a protein sample one-fortieth of the usual amount thanks to 100 kHz magic-angle-spinning NMR spectroscopy.

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September 13, 2014

Hot Paper: Enantioselective Divergent Syntheses of Several Polyhalogenated Plocamium Monoterpenes and Evaluation of Their Selectivity for Solid Tumors

Carl V. Vogel, Halina Pietraszkiewicz, Omar M. Sabry, Prof. William H. Gerwick, Dr. Frederick A. Valeriote and Prof. Christopher D. Vanderwal

Enantioselective Divergent Syntheses of Several Polyhalogenated Plocamium Monoterpenes and Evaluation of Their Selectivity for Solid TumorsGlyceraldehyde acetonide serves as a chiral glyoxal equivalent and a linchpin for the enantioselective synthesis of several acyclic polyhalogenated monoterpenes from the red algae Plocamium. Several of these compounds demonstrate selective toxicity towards solid-tumor cell lines over leukemia cell lines, as well as low-micromolar cytotoxicity towards the HCT-116 human colon carcinoma cell line.

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September 13, 2014

Hot Paper: Insect-Derived Proline-Rich Antimicrobial Peptides Kill Bacteria by Inhibiting Bacterial Protein Translation at the 70 S Ribosome

Andor Krizsan, Dr. Daniela Volke, Stefanie Weinert, Prof.Dr. Norbert Sträter, Dr. Daniel Knappe and Prof.Dr. Ralf Hoffmann

Insect-Derived Proline-Rich Antimicrobial Peptides Kill Bacteria by Inhibiting Bacterial Protein Translation at the 70 S RibosomeLost in translation: Proline-rich antimicrobial peptides (PrAMPs) inhibit bacterial protein translation by binding to the 70S ribosome of Gram-negative bacteria. This represents a novel killing mechanism for gene-encoded antimicrobial peptides. Alanine substitutions in the peptides additionally identified specific basic and hydrophobic residues as major interaction sites, which will enable the design of optimized compounds.

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September 13, 2014

VIP: Tramadol—A True Natural Product?

Dr. Souvik Kusari, Dr. Simplice Joel N. Tatsimo, Dr. Sebastian Zühlke, Dr. Ferdinand M. Talontsi, Prof. Dr. Simeon Fogue Kouam and Prof. Dr. Michael Spiteller

Tramadol—A True Natural Product?The root of the problem: Tramadol, a synthetic analgesic, was recently detected in the roots of the Cameroonian medicinal plant Nauclea latifolia. However, tramadol is not a natural product. Along with its major mammalian metabolites, tramadol is present in the roots of N. latifolia and other plant species, as well as in soil and local water sources in the Far North region of Cameroon as a result of anthropogenic contamination.

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September 12, 2014

Hot Paper: A CXCR4-Targeted Site-Specific Antibody–Drug Conjugate

Dr. Sumith A. Kularatne, Dr. Vishal Deshmukh, Dr. Jennifer Ma, Dr. Virginie Tardif, Dr. Reyna K. V. Lim, Holly M. Pugh, Dr. Ying Sun, Anthony Manibusan, Aaron J. Sellers, Dr. Richard S. Barnett, Shailaja Srinagesh, Jane S. Forsyth, Dr. Wolf Hassenpflug, Dr. Feng Tian, Dr. Tsotne Javahishvili, Prof. Brunhilde Felding-Habermann, Prof. Brian R. Lawson, Dr. Stephanie A. Kazane and Prof. Peter G. Schultz

A CXCR4-Targeted Site-Specific Antibody–Drug ConjugateHitting the mark(er): A chemically defined anti-CXCR4–auristatin antibody–drug conjugate (ADC) was produced that selectively targets and eliminates CXCR4+ metastatic cancer cells in vitro and in vivo with no significant overt toxicity. Because the CXCR4 receptor is highly expressed in the majority of metastatic cancers, a CXCR4–auristatin ADC may be useful for the treatment of a variety of metastatic malignancies.

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September 12, 2014

Hot Paper: Large-Scale Fabrication of Pseudocapacitive Glass Windows that Combine Electrochromism and Energy Storage

Peihua Yang, Peng Sun, Zhisheng Chai, Prof. Langhuan Huang, Dr. Xiang Cai, Prof. Shaozao Tan, Prof. Jinhui Song and Prof. Wenjie Mai

Large-Scale Fabrication of Pseudocapacitive Glass Windows that Combine Electrochromism and Energy StorageA pseudocapacitive glass window (15×15 cm2) is obtained by the deposition of WO3 on fluorine-doped tin oxide glass. Such smart pseudocapacitive glass windows show great potential in functioning as electrochromic windows and concurrently powering electronic devices, such as mobile phones or laptops.

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September 12, 2014

Hot Paper: Hexagonal Transition-Metal Chalcogenide Nanoflakes with Pronounced Lateral Quantum Confinement

Dr. Pere Miró, Jae Hyo Han, Prof. Dr. Jinwoo Cheon and Prof. Dr. Thomas Heine

Hexagonal Transition-Metal Chalcogenide Nanoflakes with Pronounced Lateral Quantum ConfinementSix-sided flakes: Transition-metal dichalcogenide nanoflakes of composition MX2 (where M=Ti, Zr and Hf; X=S and Se) grow preferentially in equilateral hexagons and exhibit a pronounced lateral quantum confinement. The hexagonal shape arises from the charge location at the edges and vertices and the resulting Coulombic repulsion.

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September 12, 2014

Hot Paper: Carbon Nanofibers Decorated with Molybdenum Disulfide Nanosheets: Synergistic Lithium Storage and Enhanced Electrochemical Performance

Fei Zhou, Dr. Sen Xin, Dr. Hai-Wei Liang, Lu-Ting Song and Prof. Dr. Shu-Hong Yu

Carbon Nanofibers Decorated with Molybdenum Disulfide Nanosheets: Synergistic Lithium Storage and Enhanced Electrochemical PerformanceCarbon nanofibers (CNFs) decorated with molybdenum disulfide sheets are fabricated by a facile hydrothermal process with low-cost, biomass-derived carbonaceous nanofibers as the supports. On reacting with lithium, the nanofibers undergo novel electrochemical processes that are triggered by a synergistic lithium storage effect, leading to enhanced cycling and rate performance of the lithium-ion battery.

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September 12, 2014

VIP: Chemical Probes for the Functionalization of Polyketide Intermediates

Dr. Elena Riva, Dr. Ina Wilkening, Silvia Gazzola, W. M. Ariel Li, Dr. Luke Smith, Prof. Peter F. Leadlay and Dr. Manuela Tosin

Chemical Probes for the Functionalization of Polyketide IntermediatesTowards novel “unnatural” products: Fermentation of ACP mutants of S. lasaliensis in the presence of functionalized chemical probes with subsequent site-selective modifications generates a library of nonnatural lasalocid A precursors and derivatives.

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September 12, 2014

VIP: Translating Bacterial Detection by DNAzymes into a Litmus Test

Kha Tram, Pushpinder Kanda, Prof. Dr. Bruno J. Salena, Prof. Dr. Shuangyan Huan and Prof. Dr. Yingfu Li

Translating Bacterial Detection by DNAzymes into a Litmus TestA new way to use the litmus test: Cheap and widely available litmus dyes and pH papers have been used to achieve the detection of a bacterial pathogen (star) through the use of an RNA-cleaving DNAzyme (RCD), urease (Ur), and magnetic beads (MB). The method allowed the sensitive detection of E. coli in complex sample matrices such as apple juice, milk, and lake water.

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September 11, 2014

Hot Paper: Radical C[BOND]H Functionalization of Heteroarenes under Electrochemical Control

Dr. Alexander G. O'Brien, Dr. Akinobu Maruyama, Dr. Yasuhide Inokuma, Prof. Makoto Fujita, Prof. Phil S. Baran and Prof. Donna G. Blackmond

Radical C<img src="http://onlinelibrarystatic.wiley.com/undisplayable_characters/00f8ff.gif" alt="[BOND]" />H Functionalization of Heteroarenes under Electrochemical ControlElectrochemical reactions are shown to be effective for the C[BOND]H functionalization of a number of heterocyclic substrates that are recalcitrant to conventional peroxide radical initiation conditions and of interest in medicinal chemistry. Monitoring reaction progress under electrochemical conditions provides mechanistic insight into the C[BOND]H functionalization process.

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September 17, 2014
Angewandte Chemie 39/2014: Chemical Logic

September 16, 2014
VIP: De Novo 3D Structure Determination from Sub-milligram Protein Samples by Solid-State 100 kHz MAS NMR Spectroscopy

September 13, 2014
Hot Paper: Enantioselective Divergent Syntheses of Several Polyhalogenated Plocamium Monoterpenes and Evaluation of Their Selectivity for Solid Tumors

September 13, 2014
Hot Paper: Insect-Derived Proline-Rich Antimicrobial Peptides Kill Bacteria by Inhibiting Bacterial Protein Translation at the 70 S Ribosome

September 13, 2014
VIP: Tramadol—A True Natural Product?

September 12, 2014
Hot Paper: A CXCR4-Targeted Site-Specific Antibody–Drug Conjugate

September 12, 2014
Hot Paper: Large-Scale Fabrication of Pseudocapacitive Glass Windows that Combine Electrochromism and Energy Storage

September 12, 2014
Hot Paper: Hexagonal Transition-Metal Chalcogenide Nanoflakes with Pronounced Lateral Quantum Confinement

September 12, 2014
Hot Paper: Carbon Nanofibers Decorated with Molybdenum Disulfide Nanosheets: Synergistic Lithium Storage and Enhanced Electrochemical Performance

September 12, 2014
VIP: Chemical Probes for the Functionalization of Polyketide Intermediates

September 12, 2014
VIP: Translating Bacterial Detection by DNAzymes into a Litmus Test

September 11, 2014
Hot Paper: Radical C[BOND]H Functionalization of Heteroarenes under Electrochemical Control

September 10, 2014
Angewandte Chemie 38/2014: Nobel Chemistry

September 10, 2014
Hot Paper: Insertion of Nitriles into Zirconocene-1-aza-1,3-diene Complexes: Chemoselective Synthesis of N-H and N-Substituted Pyrroles

September 10, 2014
Hot Paper: Differential Reduction of CO2 by Molybdenum and Vanadium Nitrogenases

September 10, 2014
VIP: Nanocrystalline-Graphene-Tailored Hexagonal Boron Nitride Thin Films

September 06, 2014
Hot Paper: Anion Complexation and The Hofmeister Effect

September 06, 2014
VIP: Separating Para and Ortho Water

September 05, 2014
Hot Paper: An Organotrifluoroborate for Broadly Applicable One-Step 18F-Labeling

September 05, 2014
Hot Paper: Engineering Catalyst Microenvironments for Metal-Catalyzed Hydrogenation of Biologically Derived Platform Chemicals

September 05, 2014
Hot Paper: In Vivo Residue-Specific Dopa-Incorporated Engineered Mussel Bioglue with Enhanced Adhesion and Water Resistance

September 05, 2014
Hot Paper: Enantioselective Synthesis of Piperidines through the Formation of Chiral Mixed Phosphoric Acid Acetals: Experimental and Theoretical Studies

September 05, 2014
Hot Paper: Gas-Phase Preparation of Carbonic Acid and Its Monomethyl Ester

September 05, 2014
Hot Paper: Organic Dicarboxylate Negative Electrode Materials with Remarkably Small Strain for High-Voltage Bipolar Batteries

September 05, 2014
Hot Paper: Forazoline A: Marine-Derived Polyketide with Antifungal In Vivo Efficacy

September 05, 2014
Hot Paper: Exploring Weak Ligand–Protein Interactions by Long-Lived NMR States : Improved Contrast in Fragment-Based Drug Screening

September 05, 2014
VIP: Epitaxial Seeded Growth of Rare-Earth Nanocrystals with Efficient 800 nm Near-Infrared to 1525 nm Short-Wavelength Infrared Downconversion Photoluminescence for In Vivo Bioimaging

September 05, 2014
VIP: Dissecting Ubiquitin Signaling with Linkage-defined and Protease Resistant Ubiquitin Chains

September 05, 2014
VIP: Watson–Crick Base Pairing Controls Excited-State Decay in Natural DNA

September 03, 2014
Angewandte Chemie 37/2014: Amazing Stories

August 29, 2014
Angewandte Chemie 36/2014: Click to Synthesize

August 29, 2014
Hot Paper: Hot-Electron-Transfer Enhancement for the Efficient Energy Conversion of Visible Light

August 29, 2014
Hot Paper: Anion–π and Cation–π Interactions on the Same Surface

August 29, 2014
Hot Paper: Hydrogen from Formic Acid through Its Selective Disproportionation over Sodium Germanate—A Non-Transition-Metal Catalysis System

August 29, 2014
Hot Paper: The optimally performing Fischer–Tropsch catalyst

August 29, 2014
VIP: Bipolar Tribocharging Signal During Friction Force Fluctuations at Metal–Insulator Interfaces

August 29, 2014
VIP: Unravelling the Correlation between the Aspect Ratio of Nanotubular Structures and Their Electrochemical Performance To Achieve High-Rate and Long-Life Lithium-Ion Batteries

August 28, 2014
Hot Paper: Super-Resolution Imaging of Plasma Membrane Glycans

August 28, 2014
Hot Paper: Direct Catalytic Olefination of Alcohols with Sulfones

August 28, 2014
Hot Paper: Dialdehydes Lead to Exceptionally Fast Bioconjugations at Neutral pH by Virtue of a Cyclic Intermediate

August 28, 2014
VIP: Sustainable Electrical Energy Storage through the Ferrocene/Ferrocenium Redox Reaction in Aprotic Electrolyte

August 26, 2014
Hot Paper: Aldehyde-Assisted Ruthenium(II)-Catalyzed C[BOND]H Oxygenations

August 26, 2014
VIP: Core/Shell Au/MnO Nanoparticles Prepared Through Controlled Oxidation of AuMn as an Electrocatalyst for Sensitive H2O2 Detection

August 26, 2014
VIP: A Lightweight Polymer Solar Cell Textile that Functions when Illuminated from Either Side

August 26, 2014
Hot Paper: Controlling Selectivity in the Chlorine Evolution Reaction over RuO2-Based Catalysts

August 26, 2014
VIP: Highly Diastereoselective and Enantiospecific Allylation of Ketones and Imines Using Borinic Esters: Contiguous Quaternary Stereogenic Centers

August 26, 2014
VIP: Exceptional Isotopic-Substitution Effect: Breakdown of Collective Proton Tunneling in Hexagonal Ice due to Partial Deuteration

August 22, 2014
Angewandte Chemie 35/2014: Inspiration and Automation

August 22, 2014
Hot Paper: Unexpected Synergy between Magnetic Iron Chains and Stacked B6 Rings in Nb6Fe1−xIr6+xB8

August 22, 2014
Hot Paper: Vanadium-Catalyzed Solvent-Free Synthesis of Quaternary α-Trifluoromethyl Nitriles by Electrophilic Trifluoromethylation

August 22, 2014
Hot Paper: Ruthenium-Catalyzed Reductive Methylation of Imines Using Carbon Dioxide and Molecular Hydrogen

August 22, 2014
VIP: Long-Lived Trifluoromethanide Anion: A Key Intermediate in Nucleophilic Trifluoromethylations

August 20, 2014
Hot Paper: Planet–Satellite Nanostructures Made To Order by RAFT Star Polymers

August 20, 2014
Hot Paper: Phosphonated Near-Infrared Fluorophores for Biomedical Imaging of Bone

August 20, 2014
VIP: Chiral Amine Synthesis Using ω-Transaminases: An Amine Donor that Displaces Equilibria and Enables High-Throughput Screening

August 20, 2014
VIP: Reconfigurable Swarms of Nematic Colloids Controlled by Photoactivated Surface Patterns

August 19, 2014
Max Planck Institute for Coal Research Celebrates 100th Anniversary

August 15, 2014
Hot Paper: Harvesting Solar Light with Crystalline Carbon Nitrides for Efficient Photocatalytic Hydrogen Evolution

August 15, 2014
Hot Paper: Oxygen Reduction Reaction in a Droplet on Graphite: Direct Evidence that the Edge is More Active than the Basal Plane

August 13, 2014
Hot Paper: One-Pot Enzymatic Synthesis of Merochlorin A and B

August 13, 2014
VIP: A Designed Conformational Shift To Control Protein Binding Specificity

August 12, 2014
Hot Paper: Metal-Free Hydrogenation Catalyzed by an Air-Stable Borane: Use of Solvent as a Frustrated Lewis Base

August 11, 2014
Hot Paper: Visualizing an Ultra-Weak Protein–Protein Interaction in Phosphorylation Signaling

August 11, 2014
Hot Paper: Carbon Dioxide as a Protecting Group: Highly Efficient and Selective Catalytic Access to Cyclic cis-Diol Scaffolds

August 11, 2014
Hot Paper: N-Heterocyclic Carbene Catalyzed Formal [3+2] Annulation Reaction of Enals: An Efficient Enantioselective Access to Spiro-Heterocycles

August 11, 2014
Hot Paper: Mononuclear and Terminal Zirconium and Hafnium Methylidenes

August 11, 2014
Hot Paper: A New Class of Organocatalysts: Sulfenate Anions

August 07, 2014
VIP: Switchable Bifunctional Stimuli-Triggered Poly-N-Isopropylacrylamide/DNA Hydrogels

August 01, 2014
Hot Paper: Ultra-Low-Field NMR Relaxation and Diffusion Measurements Using an Optical Magnetometer

April 16, 2014
VIP: Decay of FeV Nitride Complexes by a N–N Bond Coupling Reaction in Solution: A Combined Spectroscopic and Theoretical Analysis

March 05, 2014
VIP: Rate Coefficients of Criegee Intermediate (CH2OO and CH3CHOO) Reactions with Formic and Acetic Acid Are Close to Their Collision Limit: Direct Kinetics Measurements and Atmospheric Implications

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