Angewandte Chemie International Edition

Cover image for Vol. 53 Issue 31

Editor: Peter Gölitz, Deputy Editors: Neville Compton, Haymo Ross

Online ISSN: 1521-3773

Associated Title(s): Angewandte Chemie, Chemistry - A European Journal, Chemistry – An Asian Journal, Zeitschrift für Chemie

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August 01, 2014

Hot Paper: Ultra-Low-Field NMR Relaxation and Diffusion Measurements Using an Optical Magnetometer

Paul J. Ganssle, Hyun D. Shin, Dr. Scott J. Seltzer, Dr. Vikram S. Bajaj, Dr. Micah P. Ledbetter, Prof. Dmitry Budker, Dr. Svenja Knappe, Dr. John Kitching and Prof. Alexander Pines

Ultra-Low-Field NMR Relaxation and Diffusion Measurements Using an Optical MagnetometerPortable NMR: NMR relaxometry and diffusometry can be highly effective in applications where high-resolution NMR spectroscopy is unnecessary or impractical, as is the case in the emerging field of portable chemical characterization. A proof-of-concept experiment is presented demonstrating the use of high-sensitivity optical magnetometers as detectors for ultra-low-field NMR relaxation and diffusion measurements.

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August 01, 2014

Hot Paper: Super-Resolution Imaging of the Golgi in Live Cells with a Bioorthogonal Ceramide Probe

Dr. Roman S. Erdmann, Dr. Hideo Takakura, Alexander D. Thompson, Felix Rivera-Molina, Dr. Edward S. Allgeyer, Prof. Dr. Joerg Bewersdorf, Prof. Dr. Derek Toomre and Prof. Dr. Alanna Schepartz

Super-Resolution Imaging of the Golgi in Live Cells with a Bioorthogonal Ceramide ProbeSeeing is believing: A new lipid-based strategy to visualize Golgi structure and dynamics at super-resolution in live cells is presented. The method is based on two reagents: a trans-cyclooctene-containing ceramide lipid and a highly reactive, tetrazine-tagged, near-IR dye. These reagents assemble to give Cer-SiR, which enables prolonged live-cell imaging of the Golgi apparatus by 3D confocal and stimulated emission depletion (STED) microscopy.

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August 01, 2014

VIP: Reprogramming Nonribosomal Peptide Synthetases for “Clickable” Amino Acids

Dr. Hajo Kries, Rudolf Wachtel, Anja Pabst, Benedikt Wanner, David Niquille and Prof. Dr. Donald Hilvert

Reprogramming Nonribosomal Peptide Synthetases for “Clickable” Amino AcidsPocketed: A single active site mutation reprograms the substrate specificity of nonribosomal peptide synthetase adenylation domains, enabling efficient incorporation of non-natural aromatic amino acids containing unique chemical functionality for bioorthogonal labeling.

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July 31, 2014

Hot Paper: Paenilamicin: Structure and Biosynthesis of a Hybrid Nonribosomal Peptide/Polyketide Antibiotic from the Bee Pathogen Paenibacillus larvae

Sebastian Müller, Dr. Eva Garcia-Gonzalez, Dr. Andi Mainz, Gillian Hertlein, Nina C. Heid, Eva Mösker, Hans van den Elst, Prof. Dr. Herman S. Overkleeft, Priv.-Doz. Dr. Elke Genersch and Prof.Dr. Roderich D. Süssmuth

Paenilamicin: Structure and Biosynthesis of a Hybrid Nonribosomal Peptide/Polyketide Antibiotic from the Bee Pathogen Paenibacillus larvaeThe bee all and end all? American Foulbrood, which is caused by the bacterium Paenibacillus larvae, is a widespread and devastating disease of the honey bee brood. Through the isolation and structure elucidation of the antibacterial and antifungal paenilamicins, we deciphered a fascinating nonribosomal biosynthesis. The study of the secondary metabolites of P. larvae sheds light on the virulence mechanisms of this serious disease.

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July 31, 2014

Hot Paper: Tumor-Targeting of EGFR Inhibitors by Hypoxia-Mediated Activation

M. Sc. Claudia Karnthaler-Benbakka, M. Sc. Diana Groza, Mag. Kushtrim Kryeziu, Dr. Verena Pichler, Dipl.-Ing. Alexander Roller, Prof. Dr. Walter Berger, Dr. Petra Heffeter and Dr. Christian R. Kowol

Tumor-Targeting of EGFR Inhibitors by Hypoxia-Mediated ActivationTargeted attack: Receptor tyrosine-kinase inhibitors are essential cancer therapeutics, but therapy is limited by strong adverse effects. A tumor-targeting strategy for epidermal growth factor receptor (EGFR) inhibitors through hypoxia-mediated activation has now been developed. The CoIII-based prodrug showed selective hypoxic activation with release of the active EGFR inhibitor and potent anticancer activity in human xenograft models.

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July 30, 2014

Angewandte Chemie 31/2014: Sizzling Hot

Angewandte Chemie 31/2014: Sizzling HotIn this issue, many contributions are dedicated to George Whitesides on the occasion of his 75th anniversary. R. Haag et al. review protein interactions with polymer coatings and biomaterials. What are the recent developments in analytics, biochemistry, and theory beyond Teflon? In a Minireview, E. Kumacheva et al. summarize microfluidic studies of carbon dioxide. The Highlight deals with crystal structures in light harvesting and charge separation in photosynthesis (O. Einsle).

In the Communications section, T. Ohba examines size-dependent water structures in carbon nanotubes (see picture). N. L. Abbott et al. report on the change in orientation of liquid crystals anchored on monolayers of chiral versus achiral molecules. M. Hartmann and A. Studer present the cyclizing radical carboiodination, carbotelluration, and carboaminooxylation of aryl amines, and K. O. Christie et al. succeeded in the preparation of trivalent and tetravalent manganese azides.

Browse issue 31/2014 now.

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July 29, 2014

Hot Paper: Chemical Vapor Detection Using a Reconstituted Insect Olfactory Receptor Complex

Dr. Koji Sato and Prof. Shoji Takeuchi

Chemical Vapor Detection Using a Reconstituted Insect Olfactory Receptor ComplexGas sensing by ion channels: Insect olfactory receptors consist of ligand-gated ion channels. Using cell assembly and extracellular field potential recording techniques, olfactory receptor-expressing cell spheroids were formed (see picture). The spheroids electrically responded to chemical vapors at biologically relevant concentrations.

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July 28, 2014

Hot Paper: Mapping Polyamide–DNA Interactions in Human Cells Reveals a New Design Strategy for Effective Targeting of Genomic Sites

Graham S. Erwin, Devesh Bhimsaria, Asuka Eguchi and Prof. Aseem Z. Ansari

Mapping Polyamide–DNA Interactions in Human Cells Reveals a New Design Strategy for Effective Targeting of Genomic SitesSiteseeing: The first mapping of pyrrole/imidazole polyamides across several genomic sites with distinct chromatin characteristics in live cells is reported. Bioinformatic analysis of the data shows that clustered binding sites best predict binding in cells. The results point to a new design principle to deploy polyamides and perhaps other synthetic molecules to effectively target desired genomic sites in vivo.

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July 24, 2014

Hot Paper: Cell-Penetrating, Dimeric α-Helical Peptides: Nanomolar Inhibitors of HIV-1 Transcription

Sangmok Jang, Dr. Soonsil Hyun, Seoyeon Kim, Seonju Lee, Prof. Dr. Im-Soon Lee, Prof. Dr. Masanori Baba, Prof. Dr. Yan Lee and Prof. Dr. Jaehoon Yu

Cell-Penetrating, Dimeric α-Helical Peptides: Nanomolar Inhibitors of HIV-1 TranscriptionGoing viral: Nearly quantitative penetration into eukaryotic cells and effective inhibition of the elongation of the short hairpin RNA transcript TAR at low nanomolar concentrations has been achieved by using dimeric α-helical peptide bundles based on leucine (L) and lysine (K). The effective inhibition of HIV-1 replication strongly suggests that these dimers have strong potential as anti-HIV-1 drugs.

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July 24, 2014

VIP: An Easy Way To Prepare Monolithic Inorganic Oxide Aerogels

Dr. Lili Ren, Sumin Cui, Fengchao Cao and Qinghui Guo

An Easy Way To Prepare Monolithic Inorganic Oxide AerogelsNot cracking up: A drying method based on the sublimation of organic solvent allows the rapid synthesis of the monolithic inorganic oxide aerogels without cracks from wet gels. The method proceeds by endothermic evaporation of organic solvent at the outer surface followed by sublimation of solidified solvent (see picture).

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July 24, 2014

VIP: Monitoring Morphology and Hydrogen Coverage of Nanometric Pt/γ-Al2O3 Particles by In Situ HERFD–XANES and Quantum Simulations

Agnes Gorczyca, Dr. Virginie Moizan, Dr. Celine Chizallet, Dr. Olivier Proux, William Del Net, Eric Lahera, Dr. Jean-Louis Hazemann, Dr. Pascal Raybaud and Dr. Yves Joly

Monitoring Morphology and Hydrogen Coverage of Nanometric Pt/γ-Al2O3 Particles by In Situ HERFD–XANES and Quantum SimulationsIdentifying the morphology of platinum nanoclusters supported on γ-alumina and the hydrogen coverage at a given temperature and hydrogen pressure is possible. The use of state-of-the-art methodologies combining high-resolution X-ray absorption near edge structure (XANES) in situ experiments, quantum molecular dynamics calculations, and XANES simulations gives unrivalled insights into catalyst characterization.

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July 22, 2014

Hot Paper: Coordination-Driven In Situ Self-Assembly Strategy for the Preparation of Metal–Organic-Framework Hybrid Membranes

Rong Zhang, Prof. Shulan Ji, Dr. Naixin Wang, Lin Wang, Prof. Guojun Zhang and Jian-Rong Li

Coordination-Driven In Situ Self-Assembly Strategy for the Preparation of Metal–Organic-Framework Hybrid MembranesMopping up the mess: A hybrid membrane composed of the metal–organic framework (MOF) ZIF-8 and poly(sodium 4-styrenesulfonate) was prepared by coordination-driven in situ self-assembly method. The MOF particles were well-dispersed in the polymer in the resulting stable membrane (see picture), which showed excellent performance in the nanofiltration and separation of dyes from water.

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August 01, 2014
Hot Paper: Ultra-Low-Field NMR Relaxation and Diffusion Measurements Using an Optical Magnetometer

August 01, 2014
Hot Paper: Super-Resolution Imaging of the Golgi in Live Cells with a Bioorthogonal Ceramide Probe

August 01, 2014
VIP: Reprogramming Nonribosomal Peptide Synthetases for “Clickable” Amino Acids

July 31, 2014
Hot Paper: Paenilamicin: Structure and Biosynthesis of a Hybrid Nonribosomal Peptide/Polyketide Antibiotic from the Bee Pathogen Paenibacillus larvae

July 31, 2014
Hot Paper: Tumor-Targeting of EGFR Inhibitors by Hypoxia-Mediated Activation

July 30, 2014
Angewandte Chemie 31/2014: Sizzling Hot

July 29, 2014
Hot Paper: Chemical Vapor Detection Using a Reconstituted Insect Olfactory Receptor Complex

July 28, 2014
Hot Paper: Mapping Polyamide–DNA Interactions in Human Cells Reveals a New Design Strategy for Effective Targeting of Genomic Sites

July 24, 2014
Hot Paper: Cell-Penetrating, Dimeric α-Helical Peptides: Nanomolar Inhibitors of HIV-1 Transcription

July 24, 2014
VIP: An Easy Way To Prepare Monolithic Inorganic Oxide Aerogels

July 24, 2014
VIP: Monitoring Morphology and Hydrogen Coverage of Nanometric Pt/γ-Al2O3 Particles by In Situ HERFD–XANES and Quantum Simulations

July 22, 2014
Hot Paper: Coordination-Driven In Situ Self-Assembly Strategy for the Preparation of Metal–Organic-Framework Hybrid Membranes

July 22, 2014
Hot Paper: Unprecedented Role of Hydronaphthoquinone Tautomers in Biosynthesis

July 22, 2014
Hot Paper: A Fast Deposition-Crystallization Procedure for Highly Efficient Lead Iodide Perovskite Thin-Film Solar Cells

July 22, 2014
Hot Paper: Local Transient Unfolding of Native State PAI-1 Associated with Serpin Metastability

July 22, 2014
VIP: Integrating Perovskite Solar Cells into a Flexible Fiber

July 18, 2014
Hot Paper: One-Pot Synthesis of Highly Substituted Polyheteroaromatic Compounds by Rhodium(III)-Catalyzed Multiple C[BOND]H Activation and Annulation

July 18, 2014
Hot Paper: Plasmon-Induced Ammonia Synthesis through Nitrogen Photofixation with Visible Light Irradiation

July 18, 2014
Hot Paper: Selective Capture of Carbon Dioxide under Humid Conditions by Hydrophobic Chabazite-Type Zeolitic Imidazolate Frameworks

July 18, 2014
VIP: Bonding Nature of Local Structural Motifs in Amorphous GeTe

July 16, 2014
Angewandte Chemie 29/2014: Four Stars

July 16, 2014
Hot Paper: High-Performance Hole-Extraction Layer of Sol–Gel-Processed NiO Nanocrystals for Inverted Planar Perovskite Solar Cells

July 16, 2014
Hot Paper: Synthesis of (+)-Discodermolide by Catalytic Stereoselective Borylation Reactions

July 16, 2014
Hot Paper: Reversible Supramolecular Assembly at Specific DNA Sites: Nickel-Promoted Bivalent DNA Binding with Designed Peptide and Bipyridyl–Bis(benzamidine) Components

July 16, 2014
Hot Paper: A Polyphenylene Support for Pd Catalysts with Exceptional Catalytic Activity

July 16, 2014
VIP: Stereocontrolled Synthesis of 1,5-Stereogenic Centers through Three-Carbon Homologation of Boronic Esters

July 15, 2014
Hot Paper: Selective Photoelectrochemical Reduction of Aqueous CO2 to CO by Solvated Electrons

July 15, 2014
Hot Paper: Mild and Versatile Nitrate-Promoted C[BOND]H Bond Fluorination

July 15, 2014
VIP: In Situ Quantification and Visualization of Lithium Transport with Neutrons

July 14, 2014
Hot Paper: Charge Asymmetry at Aqueous Hydrophobic Interfaces and Hydration Shells

July 14, 2014
VIP: High Correlation between Oxidation Loci on Graphene Oxide

July 11, 2014
Hot Paper: Asymmetric Synthesis of Highly Substituted β-Lactones through Oxidative Carbene Catalysis with LiCl as Cooperative Lewis Acid

July 11, 2014
Hot Paper: Organic Chemistry as a Language and the Implications of Chemical Linguistics for Structural and Retrosynthetic Analyses

July 10, 2014
Hot Paper: Visual Displays that Directly Interface and Provide Read-Outs of Molecular States via Molecular Graphics Processing Units

July 10, 2014
Hot Paper: The Structure of a Transient Complex of a Nonribosomal Peptide Synthetase and a Cytochrome P450 Monooxygenase

July 10, 2014
Hot Paper: Analysis of Diazofluorene DNA Binding and Damaging Activity: DNA Cleavage by a Synthetic Monomeric Diazofluorene

July 10, 2014
Hot Paper: Cooperative, Reversible Self-Assembly of Covalently Pre-Linked Proteins into Giant Fibrous Structures

July 10, 2014
Hot Paper: Defect Chemistry of Singly and Doubly Doped Ceria: Correlation between Ion Transport and Energetics

July 10, 2014
Hot Paper: Chlorine-Free Pyrotechnics: Copper(I) Iodide as a “Green” Blue-Light Emitter

July 08, 2014
Hot Paper: Light-Driven Organocatalysis Using Inexpensive, Nontoxic Bi2O3 as the Photocatalyst

July 08, 2014
Hot Paper: Enzymetically Regulating the Self-Healing of Protein Hydrogels with High Healing Efficiency

July 08, 2014
Hot Paper: “CLASSIC NMR”: An In-Situ NMR Strategy for Mapping the Time-Evolution of Crystallization Processes by Combined Liquid-State and Solid-State Measurements

July 08, 2014
Hot Paper: Selection of DNA-Encoded Small Molecule Libraries Against Unmodified and Non-Immobilized Protein Targets

July 08, 2014
VIP: Membrane Deformation by Neolectins with Engineered Glycolipid Binding Sites

July 03, 2014
Angewandte Chemie 28/2014: The Sweet Smell of Success

July 03, 2014
Hot Paper: Plasmon-Assisted Water Splitting Using Two Sides of the Same SrTiO3 Single-Crystal Substrate: Conversion of Visible Light to Chemical Energy

July 03, 2014
Hot Paper: Total Chemical Synthesis of Biologically Active Fluorescent Dye-Labeled Ts1 Toxin

July 03, 2014
Hot Paper: Collisional and Coulombic Unfolding of Gas-Phase Proteins: High Correlation to Their Domain Structures in Solution

July 03, 2014
Hot Paper: Bi[BOND]Zn Bond Formation in Liquid Ammonia Solution: [Bi[BOND]Zn[BOND]Bi]4−, a Linear Polyanion that is Iso(valence)-electronic to CO2

July 03, 2014
Hot Paper: “Raft” Formation by Two-Dimensional Self-Assembly of Block Copolymer Rod Micelles in Aqueous Solution

July 03, 2014
Hot Paper: Motion Capture and Manipulation of a Single Synthetic Molecular Rotor by Optical Microscopy

July 03, 2014
Hot Paper: A Metal-Free Three-Component Reaction for the Regioselective Synthesis of 1,4,5-Trisubstituted 1,2,3-Triazoles

July 03, 2014
Hot Paper: Development of Multinuclear Polymeric Nanoparticles as Robust Protein Nanocarriers

July 03, 2014
VIP: Synthesis of Two-Dimensional Transition-Metal Phosphates with Highly Ordered Mesoporous Structures for Lithium-Ion Battery Applications

July 03, 2014
VIP: A High-Pressure NMR Probe for Aqueous Geochemistry

July 03, 2014
VIP: Search for a Strong, Virtually “No-Shift” Hydrogen Bond: A Cage Molecule with an Exceptional OH⋅⋅⋅F Interaction

July 03, 2014
VIP: A Protein-Based Pentavalent Inhibitor of the Cholera Toxin B-Subunit

July 02, 2014
Hot Paper: An Unusual Protein–Protein Interaction through Coupled Unfolding and Binding

July 02, 2014
Hot Paper: [2+2] Cycloaddition of 1,3-Dienes by Visible Light Photocatalysis

July 02, 2014
Hot Paper: Access to β-Lactams by Enantioselective Palladium(0)-Catalyzed C(sp3)[BOND]H Alkylation

July 02, 2014
Hot Paper: Potassium 1,1′-Dinitramino-5,5′-bistetrazolate: A Primary Explosive with Fast Detonation and High Initiation Power

July 02, 2014
Hot Paper: Trinuclear Gold Clusters Supported by Cyclic (alkyl)(amino)carbene Ligands: Mimics for Gold Heterogeneous Catalysts

July 01, 2014
Hot Paper: Isolation of a Bis(oxazol-2-ylidene)–Phenylborylene Adduct and its Reactivity as a Boron-Centered Nucleophile

July 01, 2014
VIP: Alkene–Tetrazine Ligation for Imaging Cellular DNA

June 27, 2014
Hot Paper: The Ketene-Surrogate Coupling: Catalytic Conversion of Aryl Iodides into Aryl Ketenes through Ynol Ethers

June 26, 2014
Hot Paper: A Plausible Simultaneous Synthesis of Amino Acids and Simple Peptides on the Primordial Earth

June 26, 2014
Hot Paper: Broad-Spectrum Catalysts for the Ambient Temperature Anti-Markovnikov Hydration of Alkynes

June 26, 2014
Hot Paper: Catalyst-Dependent Divergent Synthesis of Pyrroles from 3-Alkynyl Imine Derivatives: A Noncarbonylative and Carbonylative Approach

June 25, 2014
Hot Paper: Structurally Homogeneous Nanosheets from Self-Assembly of a Collagen-Mimetic Peptide

June 25, 2014
Hot Paper: Synthesis of a Specified, Silica Molecular Sieve by Using Computationally Predicted Organic Structure-Directing Agents

June 25, 2014
Hot Paper: Synthesis of (Carbo)nucleoside Analogues by [3+2] Annulation of Aminocyclopropanes

June 25, 2014
Hot Paper: An Ultrastable Anode for Long-Life Room-Temperature Sodium-Ion Batteries

June 25, 2014
Hot Paper: A Supercharged Fluorescent Protein as a Versatile Probe for Homogenous DNA Detection and Methylation Analysis

June 25, 2014
Hot Paper: Bio-reduction of Redox-Sensitive Albumin Conjugates in FcRn-Expressing Cells

June 21, 2014
Hot Paper: Isolation of a Non-Heteroatom-Stabilized Gold–Carbene Complex

June 19, 2014
Hot Paper: A De Novo Designed Metalloenzyme for the Hydration of CO2

June 19, 2014
Hot Paper: Hydrogen Storage in a Potassium-Ion-Bound Metal–Organic Framework Incorporating Crown Ether Struts as Specific Cation Binding Sites

June 16, 2014
Hot Paper: Photodegradable Hydrogels for Capture, Detection, and Release of Live Cells

June 16, 2014
Hot Paper: Rational Design and Identification of a Non-Peptidic Aggregation Inhibitor of Amyloid-β Based on a Pharmacophore Motif Obtained from cyclo[-Lys-Leu-Val-Phe-Phe-]

June 11, 2014
Hot Paper: A General Copper-Mediated Nucleophilic 18F Fluorination of Arenes

May 05, 2014
VIP: Aqueous Heterogeneity at the Air/Water Interface Revealed by Two-Dimensional Phase-Sensitive Sum-Frequency Generation Spectroscopy

April 16, 2014
VIP: Decay of FeV Nitride Complexes by a N–N Bond Coupling Reaction in Solution: A Combined Spectroscopic and Theoretical Analysis

March 19, 2014
VIP: Threshold Sensing by a Synthetic Enzymatic Reaction–Diffusion Network

March 05, 2014
VIP: Rate Coefficients of Criegee Intermediate (CH2OO and CH3CHOO) Reactions with Formic and Acetic Acid Are Close to Their Collision Limit: Direct Kinetics Measurements and Atmospheric Implications

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