Angewandte Chemie International Edition

Cover image for Vol. 54 Issue 33

Editor: Peter Gölitz, Deputy Editors: Neville Compton, Haymo Ross

Online ISSN: 1521-3773

Associated Title(s): Angewandte Chemie, Chemistry - A European Journal, Chemistry – An Asian Journal, ChemistryOpen, ChemPlusChem, Zeitschrift für Chemie

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August 01, 2015

Hot Paper: Systemic Fluorescence Imaging of Zebrafish Glycans with Bioorthogonal Chemistry

Paresh Agarwal, Brendan J. Beahm, Peyton Shieh and Prof. Carolyn R. Bertozzi

Systemic Fluorescence Imaging of Zebrafish Glycans with Bioorthogonal ChemistryHow exSiating! Systemic fluorescence imaging of cell-surface glycans inside a live animal is described for the first time. Metabolic incorporation of a cyclooctyne-functionalized sialic acid into glycans during zebrafish embryogenesis followed by ligation with a fluorogenic tetrazine enables the visualization of sialoglycoconjugates.

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August 01, 2015

VIP: Finely Tuned Polymer Interlayers Enhance Solar Cell Efficiency

Dr. Yao Liu, Zachariah A. Page, Prof. Dr. Thomas P. Russell and Prof. Dr. Todd Emrick

Finely Tuned Polymer Interlayers Enhance Solar Cell EfficiencyOrganic electronics: Three conjugated polymer zwitterions of variable bandgap were synthesized and incorporated as cathode modification layers in bulk heterojunction solar cells, boosting the power conversion efficiency (PCE) to over 10 %. Structure–property relationships identified key optical and electronic characteristics that lead to the observed high efficiencies.

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July 31, 2015

Hot Paper: {μ-PbSe}: A Heavy CO Homologue as an Unexpected Ligand

Dr. Günther Thiele, Yannick Franzke, Priv.-Doz. Dr. Florian Weigend and Prof. Dr. Stefanie Dehnen

{μ-PbSe}: A Heavy CO Homologue as an Unexpected LigandLike a mosquito's stinger, the second heaviest CO homologue, μ-PbSe, is attached with a distinct bent coordination mode to an Rh3Se2 cluster moiety. The ionic compound comprising the [Rh3(CN)2(PPh3)43-Se)2(μ-PbSe)]3− anion (shown) was obtained as a side product along with a larger Rh/Se cluster, and apparently arises from an unbridged species that crystallizes under slightly different reaction conditions. Experimental and quantum chemical analyses explain the nature of this uncommon ligand.

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July 31, 2015

Hot Paper: A Simple and Efficient Preparation of High-Purity Hydrogen Trioxide (HOOOH)

Gregor Strle and Prof. Dr. Janez Cerkovnik

A Simple and Efficient Preparation of High-Purity Hydrogen Trioxide (HOOOH)O3 can do: Hydrogen trioxide (HOOOH) is prepared on functionalized polymer beads and subsequently released. Solutions of high-purity HOOOH in diethyl ether, free of any reactants and by-products, may be stored at −20 °C for weeks. HOOOH could be also isolated in highly pure form or dissolved in another solvent, thus significantly extending the research perspectives of HOOOH.

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July 31, 2015

Hot Paper: Pentafulvene for the Synthesis of Complex Natural Products: Total Syntheses of (±)-Pallambins A and B

Christian Ebner and Prof. Dr. Erick M. Carreira

Pentafulvene for the Synthesis of Complex Natural Products: Total Syntheses of (±)-Pallambins A and BCore congestion: The first total syntheses of the diterpenoids (±)-pallambins A and B are reported. The use of fulvene in a Diels–Alder cycloaddition is without precedence in complex synthesis and enables, in combination with a strategic C[BOND]H insertion, rapid assembly of the tetracyclo[4.4.03,5.02,8]decane core.

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July 31, 2015

VIP: Highly Ordered Nanoporous Films from Supramolecular Diblock Copolymers with Hydrogen-Bonding Junctions

Dr. Damien Montarnal, Dr. Nicolas Delbosc, Cécile Chamignon, Dr. Marie-Alice Virolleaud, Yingdong Luo, Prof. Craig J. Hawker, Prof. Eric Drockenmuller and Dr. Julien Bernard

Highly Ordered Nanoporous Films from Supramolecular Diblock Copolymers with Hydrogen-Bonding JunctionsLink for a minute: Supramolecular diblock copolymers self-assemble from high molecular weight polymers bearing complementary strong hydrogen-bonding groups. Hierarchical organization affords thin films with excellent lateral order that can be readily transformed into porous membranes, without any degradation, by disruption of the supramolecular links with water/alcohol solutions.

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July 30, 2015

Hot Paper: Multi-Compartmental Hydrogel Microparticles Fabricated by Combination of Sequential Electrospinning and Photopatterning

Kanghee Cho, Hyun Jong Lee, San Won Han, Ji Hong Min, Prof. Hansoo Park and Prof. Won-Gun Koh

Multi-Compartmental Hydrogel Microparticles Fabricated by Combination of Sequential Electrospinning and PhotopatterningMulti-compartmental hydrogel microparticles were fabricated by combining electrospinning and photopatterning processes. Each compartment was made of a fiber matrix with different composition. the resultant microparticles have a potential for various biomedical applications such as bioassay, drug delivery, and tissue engineering.

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July 30, 2015

Hot Paper: Electrostatic Localization of RNA to Protocell Membranes by Cationic Hydrophobic Peptides

Dr. Neha P. Kamat, Dr. Sylvia Tobé, Ian T. Hill and Prof. Jack W. Szostak

Electrostatic Localization of RNA to Protocell Membranes by Cationic Hydrophobic PeptidesRNA–membrane association: Simple peptides (as small as three amino acids) can localize RNA to model membrane systems by electrostatic interactions. Microscopy studies showed that peptides can cross vesicle membranes to localize encapsulated RNA.

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July 30, 2015

Hot Paper: Metallic Single-Unit-Cell Orthorhombic Cobalt Diselenide Atomic Layers: Robust Water-Electrolysis Catalysts

Liang Liang, Dr. Hao Cheng, Fengcai Lei, Dr. Jun Han, Shan Gao, Dr. Chengming Wang, Prof. Yongfu Sun, Shaista Qamar, Prof. Shiqiang Wei and Prof. Yi Xie

Metallic Single-Unit-Cell Orthorhombic Cobalt Diselenide Atomic Layers: Robust Water-Electrolysis CatalystsThe shape of thins to come: Atomic layers bring better catalytic properties as shown by thermally exfoliating a lamellar CoSe2-DETA hybrid to give single-unit-cell orthorhombic CoSe2 sheets. The single-unit-cell thickness means that 66.7 % of the Co2+ ions are exposed on the surface and are low coordinate leading to a lower Tafel slope and higher turnover frequency in water splitting.

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July 30, 2015

VIP: Palladium-Catalyzed Decarbonylative Dehydration for the Synthesis of α-Vinyl Carbonyl Compounds and Total Synthesis of (−)-Aspewentins A, B, and C

Yiyang Liu, Dr. Scott C. Virgil, Prof. Robert H. Grubbs and Prof. Brian M. Stoltz

Palladium-Catalyzed Decarbonylative Dehydration for the Synthesis of α-Vinyl Carbonyl Compounds and Total Synthesis of (−)-Aspewentins A, B, and CVinyl unveiled: It is described that δ-oxocarboxylic acids can serve as masked vinyl compounds and be unveiled by Pd-catalyzed decarbonylative dehydration to enable the α-vinylation of carbonyl compounds to form a quaternary stereocenter. A variety of α-vinyl quaternary carbonyl compounds are obtained in good yields, and an application in the first enantioselective total synthesis of (−)-aspewentins A–C is demonstrated.

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July 29, 2015

Angewandte Chemie 32/2015: New Spin

Angewandte Chemie 32/2015: New SpinIn this issue, L. Frydman et al. review biomolecular NMR spectroscopy. How can the sensitivity of this method be improved? The Highlight deals with the production of universal blood by directed evolution (M. T. Reetz et al.). In his Editorial, A. Hirsch tackles the giant European research project that is the graphene flagship.

In the Comunications section, M. G. Kanatzidis et al. describe an intermetallic semiconductor with a non-centrosymmetric structure and the chemical formula EuIr4In2Ge4 (see picture). S. Kobayashi et al. present a method for the effective formylation of amines with CO2 and diphenylsilane, and B. Han et al. point out that porous zirconium–phytic acid hybrids are highly efficient catalysts for Meerwein–Ponndorf–Verley reductions.

Browse issue 32/2015 now.

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July 25, 2015

Hot Paper: Chemical Synthesis Elucidates the Immunological Importance of a Pyruvate Modification in the Capsular Polysaccharide of Streptococcus pneumoniae Serotype 4

Dr. Claney L. Pereira, Andreas Geissner, Dr. Chakkumkal Anish and Prof. Dr. Peter H. Seeberger

Chemical Synthesis Elucidates the Immunological Importance of a Pyruvate Modification in the Capsular Polysaccharide of Streptococcus pneumoniae Serotype 4Unusually Protective. In the search for a glycan epitope for protection against Streptococcus pneumoniae serotype 4, total synthesis of the repeating unit (see structure) enabled the identification of pyruvate as a crucial determinant of immunogenicity. This lays the foundation for the development of a new antibacterial vaccine candidate against Streptococcus pneumoniae serotype 4.

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August 01, 2015
Hot Paper: Systemic Fluorescence Imaging of Zebrafish Glycans with Bioorthogonal Chemistry

August 01, 2015
VIP: Finely Tuned Polymer Interlayers Enhance Solar Cell Efficiency

July 31, 2015
Hot Paper: {μ-PbSe}: A Heavy CO Homologue as an Unexpected Ligand

July 31, 2015
Hot Paper: A Simple and Efficient Preparation of High-Purity Hydrogen Trioxide (HOOOH)

July 31, 2015
Hot Paper: Pentafulvene for the Synthesis of Complex Natural Products: Total Syntheses of (±)-Pallambins A and B

July 31, 2015
VIP: Highly Ordered Nanoporous Films from Supramolecular Diblock Copolymers with Hydrogen-Bonding Junctions

July 30, 2015
Hot Paper: Multi-Compartmental Hydrogel Microparticles Fabricated by Combination of Sequential Electrospinning and Photopatterning

July 30, 2015
Hot Paper: Electrostatic Localization of RNA to Protocell Membranes by Cationic Hydrophobic Peptides

July 30, 2015
Hot Paper: Metallic Single-Unit-Cell Orthorhombic Cobalt Diselenide Atomic Layers: Robust Water-Electrolysis Catalysts

July 30, 2015
VIP: Palladium-Catalyzed Decarbonylative Dehydration for the Synthesis of α-Vinyl Carbonyl Compounds and Total Synthesis of (−)-Aspewentins A, B, and C

July 29, 2015
Angewandte Chemie 32/2015: New Spin

July 25, 2015
Hot Paper: Chemical Synthesis Elucidates the Immunological Importance of a Pyruvate Modification in the Capsular Polysaccharide of Streptococcus pneumoniae Serotype 4

July 24, 2015
Hot Paper: Waterproof Alkyl Phosphate Coated Fluoride Phosphors for Optoelectronic Materials

July 24, 2015
Hot Paper: Rattling in the Quadruple Perovskite CuCu3V4O12

July 24, 2015
Hot Paper: Pushing the Limits of Neutral Organic Electron Donors: A Tetra(iminophosphorano)-Substituted Bispyridinylidene

July 24, 2015
VIP: Self-Pillared, Single-Unit-Cell Sn-MFI Zeolite Nanosheets and Their Use for Glucose and Lactose Isomerization

July 22, 2015
Angewandte Chemie 31/2015: Strategies and Methods

July 22, 2015
Hot Paper: A Small-Molecule Probe for Selective Profiling and Imaging of Monoamine Oxidase B Activities in Models of Parkinson’s Disease

July 22, 2015
Hot Paper: Rechargeable Hydrogen Storage System Based on the Dehydrogenative Coupling of Ethylenediamine with Ethanol

July 18, 2015
Hot Paper: An Activity-Based Probe for Studying Crosslinking in Live Bacteria

July 18, 2015
Hot Paper: Direct Epoxidation of Propylene over Stabilized Cu+ Surface Sites on Titanium-Modified Cu2O

July 18, 2015
Hot Paper: Encapsulating Inorganic Acetylene, HBNH, Using Flanking Coordinative Interactions

July 18, 2015
Hot Paper: A Single Enzyme Transforms a Carboxylic Acid into a Nitrile through an Amide Intermediate

July 18, 2015
Hot Paper: The Nature of Bonding between Argon and Mixed Gold–Silver Trimers

July 17, 2015
VIP: Catalytic Degradation of Sulfur Hexafluoride by Rhodium Complexes

July 17, 2015
VIP: Methoxydiphenylamine-Substituted Carbazole Twin Derivative: An Efficient Hole-Transporting Material for Perovskite Solar Cells

July 16, 2015
Angewandte Chemie 30/2015: New Horizons

July 16, 2015
Hot Paper: Iron-Catalyzed Cross-Coupling of Alkenyl Acetates

July 16, 2015
Hot Paper: General Formation of MxCo3−xS4 (M=Ni, Mn, Zn) Hollow Tubular Structures for Hybrid Supercapacitors

July 16, 2015
Hot Paper: Copper and Silver Carbene Complexes without Heteroatom-Stabilization: Structure, Spectroscopy, and Relativistic Effects

July 16, 2015
Hot Paper: Poly(p-phenylenediethynylene phosphane): A Phosphorus-Containing Macromolecule that Displays Blue Fluorescence Upon Oxidation

July 16, 2015
Hot Paper: Synthesis of a Tetrabenzotetraaza[8]circulene by a “Fold-In” Oxidative Fusion Reaction

July 16, 2015
Hot Paper: One Electron Makes Differences: From Heme {FeNO}7 to {FeNO}8

July 16, 2015
VIP: Morphological and Structural Evolutions of Metal–Organic Framework Particles from Amorphous Spheres to Crystalline Hexagonal Rods

July 16, 2015
VIP: Head-to-Tail Zig-Zag Packing of Dipolar Merocyanine Dyes Affords High-Performance Organic Thin-Film Transistors

July 16, 2015
VIP: A Graphitic-C3N4 “Seaweed” Architecture for Enhanced Hydrogen Evolution

July 16, 2015
VIP: Solution-Processable Donor–Acceptor Compound Containing Boron(III) Centers for Small-Molecule-Based High-Performance Ternary Electronic Memory Devices

July 15, 2015
Angewandte Chemie 29/2015: Sensing Chemistry

July 15, 2015
Hot Paper: Single-Vehicular Delivery of Antagomir and Small Molecules to Inhibit miR-122 Function in Hepatocellular Carcinoma Cells by using “Smart” Mesoporous Silica Nanoparticles

July 15, 2015
Hot Paper: Bioinduced Room-Temperature Methanol Reforming

July 15, 2015
Hot Paper: Construction of Versatile and Functional Nanostructures Derived from CO2-based Polycarbonates

July 15, 2015
VIP: Boronate-Affinity Glycan-Oriented Surface Imprinting: A New Strategy to Mimic Lectins for the Recognition of an Intact Glycoprotein and Its Characteristic Fragments

July 07, 2015
Hot Paper: From Silylone to an Isolable Monomeric Silicon Disulfide Complex

July 04, 2015
Hot Paper: A New Perspective on Li–SO2 Batteries for Rechargeable Systems

July 04, 2015
VIP: S-Doping of an Fe/N/C ORR Catalyst for Polymer Electrolyte Membrane Fuel Cells with High Power Density

July 03, 2015
Hot Paper: A Universal Approach to Ultrasmall Magneto-Fluorescent Nanohybrids

July 02, 2015
Hot Paper: Fused Thiophene-Pyrrole-Containing Ring Systems up to a Heterodecacene

July 02, 2015
Hot Paper: Post-Assembly Stabilization of Rationally Designed DNA Crystals

July 02, 2015
VIP: 1,3-Butadienyl Dianions as Non-Innocent Ligands: Synthesis and Characterization of Aromatic Dilithio Rhodacycles

July 01, 2015
Hot Paper: Fragment-Based Discovery of a Dual pan-RET/VEGFR2 Kinase Inhibitor Optimized for Single-Agent Polypharmacology

July 01, 2015
Hot Paper: A Mixed-Valence Tri-Zinc Complex, [LZnZnZnL] (L=Bulky Amide), Bearing a Linear Chain of Two-Coordinate Zinc Atoms

July 01, 2015
Hot Paper: Enantioselective α-Alkylation of Aldehydes by Photoredox Organocatalysis: Rapid Access to Pharmacophore Fragments from β-Cyanoaldehydes

July 01, 2015
VIP: Forming Stereogenic Centers in Acyclic Systems from Alkynes

June 27, 2015
Hot Paper: Metal-Mediated Production of Isocyanates, R3EN[DOUBLE BOND]C[DOUBLE BOND]O from Dinitrogen, Carbon Dioxide, and R3ECl

June 27, 2015
Hot Paper: Structure Elucidation and Activity of Kolossin A, the D-/L-Pentadecapeptide Product of a Giant Nonribosomal Peptide Synthetase

June 27, 2015
Hot Paper: Reversible α-Hydrogen and α-Alkyl Elimination in PC(sp3)P Pincer Complexes of Iridium

June 27, 2015
VIP: A Cell-Permeable ATP Analogue for Kinase-Catalyzed Biotinylation

June 27, 2015
VIP: Methylamine-Gas Induced Defect-Healing Behavior of CH3NH3PbI3 Thin Films for Perovskite Solar Cells

June 27, 2015
VIP: Reductive Insertion of Elemental Chalcogens into Boron–Boron Multiple Bonds

June 27, 2015
VIP: Protonation-Dependent Base Flipping at Neutral pH in the Catalytic Triad of a Self-Splicing Bacterial Group II Intron

June 26, 2015
Hot Paper: Sequential Anion and Cation Exchange Reactions for Complete Material Transformations of Nanoparticles with Morphological Retention

June 26, 2015
Hot Paper: Black Gold: Plasmonic Colloidosomes with Broadband Absorption Self-Assembled from Monodispersed Gold Nanospheres by Using a Reverse Emulsion System

June 24, 2015
Hot Paper: Photonic Crystals with a Reversibly Inducible and Erasable Defect State Using External Stimuli

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