Angewandte Chemie International Edition

Cover image for Vol. 53 Issue 17

Editor: Peter Gölitz, Deputy Editors: Neville Compton, Haymo Ross

Online ISSN: 1521-3773

Associated Title(s): Angewandte Chemie, Chemistry - A European Journal, Chemistry – An Asian Journal, Zeitschrift für Chemie

News

RSS feeds: news | news + recent journal content.

April 19, 2014

Hot Paper: Stabilization of Catalytically Active Cu+ Surface Sites on Titanium–Copper Mixed-Oxide Films

Hot Paper: Stabilization of Catalytically Active Cu+ Surface Sites on Titanium–Copper Mixed-Oxide Films

Ashleigh E. Baber, Xiaofang Yang, Hyun You Kim, Kumudu Mudiyanselage, Markus Soldemo, Jonas Weissenrieder, Sanjaya D. Senanayake, Abdullah Al-Mahboob, Jerzy T. Sadowski, Jaime Evans, José A. Rodriguez, Ping Liu, Friedrich M. Hoffmann, Jingguang G. Chen, Darío J. Stacchiola*

Positively active: Copper oxide based structures were the first that could catalyze the oxidation of CO at room temperature. Their deactivation, however, is facile, because the required Cu+ state cannot be preserved under the reaction conditions. The addition of the right amount of titanium leads to mixed CuTiOx films that are thermally and chemically stable and more active CO oxidation catalysts than pure copper oxide materials.

Published online, DOI: 10.1002/anie.201402435 – Read now

Your Comment...

April 19, 2014

Hot Paper: Design of Monodisperse and Well-Defined Polypeptide-Based Polyvalent Inhibitors of Anthrax Toxin

Hot Paper: Design of Monodisperse and Well-Defined Polypeptide-Based Polyvalent Inhibitors of Anthrax Toxin

Sanket Patke, Mohan Boggara, Ronak Maheshwari, Sunit K. Srivastava, Manish Arha, Marc Douaisi, Jacob T. Martin, Ian B. Harvey, Matthew Brier, Tania Rosen, Jeremy Mogridge, Ravi S. Kane*

Quantity and spacing: A protein-engineering approach was designed to develop monodisperse polyvalent molecules based on tandem-repeat polypeptide scaffolds. This approach allowed for precise control over ligand spacing and valency of the polyvalent molecules. This approach was applied to develop potent inhibitors of anthrax lethal toxin.

Published online, DOI: 10.1002/anie.201400870 – Read now

Your Comment...

April 18, 2014

Hot Paper: Flow-Through Synthesis on Teflon-Patterned Paper To Produce Peptide Arrays for Cell-Based Assays

Hot Paper: Flow-Through Synthesis on Teflon-Patterned Paper To Produce Peptide Arrays for Cell-Based Assays

Frédérique Deiss, Wadim L. Matochko, Natasha Govindasamy, Edith Y. Lin, Ratmir Derda*

On the same page: The patterned deposition of Teflon on paper creates barriers resistant to organic solvents. The solvents confined by the pattern flow through the paper at a controlled flow-rate, which permits the flow-through synthesis of 96 peptides in parallel on one sheet of paper. The resulting peptide arrays can be used to perform cell-based assays and discover 3D materials that support cell adhesion and growth.

Published online, DOI: 10.1002/anie.201402037 – Read now

Your Comment...

April 18, 2014

Hot Paper: A Shape-Persistent Quadruply Interlocked Giant Cage Catenane with Two Distinct Pores in the Solid State

Hot Paper: A Shape-Persistent Quadruply Interlocked Giant Cage Catenane with Two Distinct Pores in the Solid State

Gang Zhang, Oliver Presly, Fraser White, Iris M. Oppel, Michael Mastalerz*

Two is better than one: During the crystallization of a giant shape-persistent organic cage compound, a dimeric catenated structure is formed by a 96-fold condensation reaction of 40 molecular subunits. The crystals of the molecular catenane contain one intrinsic mesopore (2.0 nm) and one extrinsic micropore (1.3 nm).

Published online, DOI: 10.1002/anie.201400285 – Read now

Your Comment...

April 17, 2014

Hot Paper: Co-existence of Two Different α-Synuclein Oligomers with Different Core Structures Determined by Hydrogen/Deuterium Exchange Mass Spectrometry

Hot Paper: Co-existence of Two Different α-Synuclein Oligomers with Different Core Structures Determined by Hydrogen/Deuterium Exchange Mass Spectrometry

Wojciech Paslawski, Simon Mysling, Karen Thomsen, Thomas J. D. Jørgensen*, Daniel E. Otzen*

On-pathway or off-pathway? α-Synuclein oligomers are widely accepted to be cytotoxic species in Parkinson´s disease. There is debate as to whether they are intermediate species of fibril formation or the distinct end product of aggregation. Data indicate that both are correct and two different types of α-synuclein oligomers are formed: one that can be elongated by monomers and form fibrils and a second that stacks together to form more amorphous structures.

Published online, DOI: 10.1002/anie.201400491 – Read now

Your Comment...

April 17, 2014

Hot Paper: A Molecular Approach to Self-Supported Cobalt-Substituted ZnO Materials as Remarkably Stable Electrocatalysts for Water Oxidation

Hot Paper: A Molecular Approach to Self-Supported Cobalt-Substituted ZnO Materials as Remarkably Stable Electrocatalysts for Water Oxidation

Johannes Pfrommer, Michael Lublow, Anahita Azarpira, Caren Göbel, Marcel Lücke, Alexander Steigert, Martin Pogrzeba, Prashanth W. Menezes, Anna Fischer*, Thomas Schedel-Niedrig*, Matthias Driess*

To be self-made: A cobalt-substituted zinc oxide (Co:ZnO) precatalyst was synthesized by low-temperature solvolysis of molecular heterobimetallic Co4−xZnxO4 (x=1–3) precursors. Electrophoretic deposition onto fluorinated tin oxide (FTO) electrodes leads, after oxidative conditioning, to an amorphous self-supported water-oxidation electrocatalyst that performs at very low overpotentials and with high current density for several hours.

Coming soon.

Your Comment...

April 16, 2014

VIP: Decay of FeV Nitride Complexes by a N–N Bond Coupling Reaction in Solution: A Combined Spectroscopic and Theoretical Analysis

Oliver Krahe, Eckhard Bill, and Frank Neese*

Cryogenically trapped FeV–nitride complexes with cyclam-based ligands were found to decay by bimolecular reactions, forming exclusively FeII compounds. Characterization of educts and products by Mössbauer spectroscopy, mass spectrometry, and spectroscopy-oriented DFT calculations showed that the reaction mechanism is reductive nitride coupling and release of dinitrogen (2FeV≡N→FeII-N=N-FeII→2FeII+N2). The reaction pathways, representing an "inverse" of the Haber–Bosch reaction, were computationally explored in detail, also to judge the feasibility that the converse would yield catalytically competent FeV(N). Implications for the photolytic cleavage of FeIII–azides used to generate high-valent Fe nitrides could be discussed.



Your Comment...

April 16, 2014

Hot Paper: Engineering Multifunctional Capsules through the Assembly of Metal–Phenolic Networks

Hot Paper: Engineering Multifunctional Capsules through the Assembly of Metal–Phenolic Networks

Junling Guo, Yuan Ping, Hirotaka Ejima, Karen Alt, Mirko Meissner, Joseph J. Richardson, Yan Yan, Karlheinz Peter, Dominik von Elverfeldt, Christoph E. Hagemeyer, Frank Caruso*

Multifunctional capsules: A common plant phenolic compound, tannic acid, can be used to coordinate a variety of metals through a one-step assembly process, thereby yielding a broad library of metal–phenolic network (MPN; see picture) capsules. The properties of the MPN capsules are determined by the coordinated metals.

Published online, DOI: 10.1002/anie.201311136 – Read now

Your Comment...

April 15, 2014

Angewandte Chemie 16/2014: Straight to Your Heart

Angewandte Chemie 16/2014: Straight to Your HeartIn this issue, Q.-D. Wang et al. review methods and agents of heart tissue regeneration. What are the most promising candidates and recent advances? In a Minireview, A. Quintard and J. Rodriguez discuss iron cyclopentadienone complexes. The Highlights deal with enantioselective cascade reactions (W.-J. Xiao et al.) and total syntheses of ±-aspidophylline A (E. Doris).

In the Communications section, S. Katukojvala et al. present a direct synthesis of indoles from pyrroles (see picture). M. C. McCarthy et al. determined the gas-phase structure of one of the smallest stable singlet carbenes. N. P. Farrell et al. report on the bioinorganic chemistry of apoptosis, and the role of zinc binding sites. K. A. Jørgensen et al. succeeded in the organocatalytic asymmetric synthesis of steroids.

Browse issue 16/2014 now.

Your Comment...

April 15, 2014

Hot Paper: Geminate Recombination as a Photoprotection Mechanism for Fluorescent Dyes

Hot Paper: Geminate Recombination as a Photoprotection Mechanism for Fluorescent Dyes

Phil Holzmeister, Andreas Gietl, Philip Tinnefeld*

Single-molecule spectroscopy reveals a new mechanism for diffusion-limited photoprotection. Geminate recombination after reduction of organic dyes by thiols enhances photostabilization by avoiding the buildup of photobleaching intermediates such as photo-oxidized states. Stable and long-lasting fluorescence can be achieved in combination with ROXS buffers.

Published online, DOI: 10.1002/anie.201310300 – Read now

Your Comment...

April 15, 2014

VIP: Copper-Chelating Azides for Efficient Click Conjugations in Complex Media

Valentina Bevilacqua, Mathias King, Manon Chaumontet, Marc Nothisen, Sandra Gabillet, David Buisson, Céline Puente, Alain Wagner, and Frédéric Taran*

The search for fast and high-yielding bioorthogonal ligations is of prime importance in chemical biology. To this end, clickable copper complexes were designed for ultrafast ligation with alkynes in complex biological media. The reactivity and stability of one of these copper complexes allowed efficient click reaction with alkynes within seconds inside living cells.


Your Comment...

April 09, 2014

Hot Paper: High-Quality Three-Dimensional Nanoporous Graphene

Hot Paper: High-Quality Three-Dimensional Nanoporous Graphene

Yoshikazu Ito, Yoichi Tanabe, H.-J. Qiu, Katsuaki Sugawara, Satoshi Heguri, Ngoc Han Tu, Khuong Kim Huynh, Takeshi Fujita, Takashi Takahashi, Katsumi Tanigaki, Mingwei Chen*

A nickel for your graphene: The title material was synthesized by chemical vapor deposition using nanoporous nickel. The 3D nanoporous graphene preserves 2D electronic properties, such as high electron mobility and massless Dirac fermions.

Published online, DOI: 10.1002/anie.201402662 – Read now

Your Comment...

April 19, 2014
Hot Paper: Stabilization of Catalytically Active Cu+ Surface Sites on Titanium–Copper Mixed-Oxide Films

April 19, 2014
Hot Paper: Design of Monodisperse and Well-Defined Polypeptide-Based Polyvalent Inhibitors of Anthrax Toxin

April 18, 2014
Hot Paper: Flow-Through Synthesis on Teflon-Patterned Paper To Produce Peptide Arrays for Cell-Based Assays

April 18, 2014
Hot Paper: A Shape-Persistent Quadruply Interlocked Giant Cage Catenane with Two Distinct Pores in the Solid State

April 17, 2014
Hot Paper: Co-existence of Two Different α-Synuclein Oligomers with Different Core Structures Determined by Hydrogen/Deuterium Exchange Mass Spectrometry

April 17, 2014
Hot Paper: A Molecular Approach to Self-Supported Cobalt-Substituted ZnO Materials as Remarkably Stable Electrocatalysts for Water Oxidation

April 16, 2014
VIP: Decay of FeV Nitride Complexes by a N–N Bond Coupling Reaction in Solution: A Combined Spectroscopic and Theoretical Analysis

April 16, 2014
Hot Paper: Engineering Multifunctional Capsules through the Assembly of Metal–Phenolic Networks

April 15, 2014
Angewandte Chemie 16/2014: Straight to Your Heart

April 15, 2014
Hot Paper: Geminate Recombination as a Photoprotection Mechanism for Fluorescent Dyes

April 15, 2014
VIP: Copper-Chelating Azides for Efficient Click Conjugations in Complex Media

April 09, 2014
Hot Paper: High-Quality Three-Dimensional Nanoporous Graphene

April 08, 2014
Hot Paper: Construction of Quaternary Stereogenic Carbon Centers through Copper-Catalyzed Enantioselective Allylic Cross-Coupling with Alkylboranes

April 07, 2014
Hot Paper: Constructing 3D Branched Nanowire Coated Macroporous Metal Oxide Electrodes with Homogeneous or Heterogeneous Compositions for Efficient Solar Cells

April 06, 2014
Hot Paper: Controlled Electropolymerization of Ruthenium(II) Vinylbipyridyl Complexes in Mesoporous Nanoparticle Films of TiO2

April 05, 2014
Hot Paper: Arylphosphonylation and Arylazidation of Activated Alkenes

April 04, 2014
Hot Paper: Gold-Catalyzed Intermolecular C–S Bond Formation: Efficient Synthesis of α-Substituted Vinyl Sulfones

April 03, 2014
Angewandte Chemie 15/2014: New Pathways

April 01, 2014
Hot Paper: Fusing N-Heterocyclic Carbenes with Carborane Anions

March 31, 2014
Hot Paper: Bidirectional Regulation of mRNA Translation in Mammalian Cells by Using PUF Domains

March 30, 2014
Hot Paper: Structure of a Reactive Gold Carbenoid

March 29, 2014
Hot Paper: Single Crystals Popping Under UV Light: A Photosalient Effect Triggered by a [2+2] Cycloaddition Reaction

March 28, 2014
Angewandte Chemie 14/2014: Can You Do Without?

March 28, 2014
Hot Paper: Late-Stage Functionalization of Biologically Active Heterocycles Through Photoredox Catalysis

March 27, 2014
Hot Paper: Metal-Free Photochemical Aromatic Perfluoroalkylation of α-Cyano Arylacetates

March 25, 2014
VIP: Sequential Intra-Intercellular Nanoparticle Delivery System for Deep Tumor Penetration

March 25, 2014
Hot Paper: Amide Synthesis by Nucleophilic Attack of Vinyl Azides

March 24, 2014
Hot Paper: An Integrated Photoelectrochemical–Chemical Loop for Solar-Driven Overall Splitting of Hydrogen Sulfide

March 23, 2014
Hot Paper: A New Pathway of DNA G-Quadruplex Formation

March 22, 2014
Hot Paper: A Facile Synthesis of Dynamic, Shape-Changing Polymer Particles

March 21, 2014
Hot Paper: A Trinuclear Pd3O2 Intermediate in Aerobic Oxidation Catalysis

March 20, 2014
Hot Paper: Selective Janus Particle Assembly at Tipping Points of Thermally-Switched Wetting

March 19, 2014
VIP: Threshold Sensing by a Synthetic Enzymatic Reaction–Diffusion Network

March 17, 2014
Hot Paper: Antimicrobial Poly(2-methyloxazoline)s with Bioswitchable Activity through Satellite Group Modification

March 16, 2014
Hot Paper: Total Chemical Synthesis of the Enzyme Sortase AΔN59 with Full Catalytic Activity

March 15, 2014
Hot Paper: A Simple 3,4-Ethylenedioxythiophene Based Hole-Transporting Material for Perovskite Solar Cells

March 14, 2014
VIP: Towards a Sustainable Synthesis of Formate Salts: Combined Catalytic Methanol Dehydrogenation and Bicarbonate Hydrogenation

March 14, 2014
VIP: Structure of Transient Amyloid-β Oligomers Differs From Less Toxic Fibrils in Regions Known to Harbor Familial Alzheimer Mutations

March 14, 2014
Hot Paper: Peapod-Type Nanocomposites through the In Situ Growth of Gold Nanoparticles within Preformed Hexaniobate Nanoscrolls

March 13, 2014
Hot Paper: Functionalizing Single Crystals: Incorporation of Nanoparticles Inside Gel-Grown Calcite Crystals

March 12, 2014
Hot Paper: Direct UV-Induced Functionalization of Surface Hydroxy Groups by Thiol–Ol Chemistry

March 12, 2014
Hot Paper: Rhodium Enalcarbenoids: Direct Synthesis of Indoles by Rhodium(II)-Catalyzed [4+2] Benzannulation of Pyrroles

March 10, 2014
VIP: How Does a Coordinated Radical Ligand Affect the Spin Crossover Properties in an Octahedral Iron(II) Complex?

March 10, 2014
Hot Paper: A Brønsted Acid Catalyzed Redox Arylation

March 09, 2014
Hot Paper: Nanosized Heterostructures of Au@Prussian Blue Analogues: Towards Multifunctionality at the Nanoscale

March 07, 2014
VIP: The Compressibility of pH-Sensitive Microgels at the Oil–Water Interface: Higher Charge Leads to Less Repulsion

March 06, 2014
VIP: Chemoselective Intermolecular α-Arylation of Amides

March 05, 2014
VIP: Rate Coefficients of Criegee Intermediate (CH2OO and CH3CHOO) Reactions with Formic and Acetic Acid Are Close to Their Collision Limit: Direct Kinetics Measurements and Atmospheric Implications

March 05, 2014
Hot Paper: All Organic Sodium-Ion Batteries with Na4C8H2O6

March 04, 2014
Hot Paper: The Formation and Self-Assembly of Long Prebiotic Oligomers Produced by the Condensation of Unactivated Amino Acids on Oxide Surfaces

March 03, 2014
VIP: Synthesis of Tris- and Tetrakis(pentafluoroethyl)silanes

March 01, 2014
Hot Paper: Cyclization of Gold Acetylides: Synthesis of Vinyl Sulfonates via Gold Vinylidene Complexes

February 28, 2014
VIP: An Efficient and Modular Route to Sequence-Defined Polymers Appended to DNA

February 27, 2014
Hot Paper: Interaction with the Surrounding Water Plays a Key Role in Determining the Aggregation Propensity of Proteins

February 26, 2014
Hot Paper: Carbon Nanotubes/Heteroatom-Doped Carbon Core–Sheath Nanostructures as Highly Active, Metal-Free Oxygen Reduction Electrocatalysts for Alkaline Fuel Cells

February 26, 2014
VIP: Confirmed by X-ray Crystallography: The B·B One-Electron σ Bond

February 25, 2014
VIP: In Vivo Liver Cancer Chemoembolization and Magnetic Resonance Imaging Using Iron Oxide Nanoshell/Doxorubicin/Poly(vinyl alcohol) Hybrid Composites

February 24, 2014
VIP: A Volatile Lactone of Hymenoscyphus Pseudoalbidus, Pathogen of European Ash Dieback, Inhibits Host Germination

February 24, 2014
VIP: Metal- and Reagent-Free Highly Selective Anodic Cross-Coupling Reaction of Phenols

February 24, 2014
VIP: Mechanically Driven Activation of Polyaniline into Its Conductive Form

February 24, 2014
VIP: Probing Transient Conformational States of Proteins by Solid-State R Relaxation-Dispersion NMR Spectroscopy

February 24, 2014
VIP: Merging Aerobic Oxidation and Enamine Catalysis in Asymmetric α-Amination of β-Ketocarbonyls Using N-Hydroxycarbamates as Nitrogen Sources

February 24, 2014
VIP: The Potent Oxidant Anticancer Activity of Organoiridium Catalysts

February 24, 2014
VIP: Superior Rechargeability and Efficiency of Li-O2 Batteries: Hierarchical Air Electrode Architecture Combined with a Soluble Catalyst

January 31, 2014
VIP: Enantioselective N–H Insertion Reaction of α-Diazoketones

January 31, 2014
VIP: The Role of Ligand-Field States in the Ultrafast Photophysical Cycle of the Prototypical Iron(II) Spin-Crossover Compound [Fe(propyltetrazole)6](BF4)2

January 13, 2014
VIP: Total Chemical Synthesis and Biological Activities of Glycosylated and Non-Glycosylated Forms of the Chemokines CCL1 and Ser-CCL1

November 28, 2013
VIP: A Diiron(III,IV) Imido Species Active in Nitrene Transfer Reactions

October 25, 2013
VIP: Recoding the Genetic Code with Selenocysteine

October 25, 2013
VIP: Foldamer-Mediated Remote Stereocontrol: Up to 1,60-Asymmetric Induction

October 21, 2013
VIP: Palladium and Platinum η2-Disilyne Complexes Bearing an Isolable Dialkyldisilyne as a Ligand

Archive

SEARCH

SEARCH BY CITATION