Angewandte Chemie International Edition

Cover image for Vol. 53 Issue 48

Editor: Peter Gölitz, Deputy Editors: Neville Compton, Haymo Ross

Online ISSN: 1521-3773

Associated Title(s): Angewandte Chemie, Chemistry - A European Journal, Chemistry – An Asian Journal, ChemistryOpen, ChemPlusChem, Zeitschrift für Chemie

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November 21, 2014

Hot Paper: Design and Synthesis of High-Affinity Dimeric Inhibitors Targeting the Interactions between Gephyrin and Inhibitory Neurotransmitter Receptors

Dr. Hans Michael Maric, Vikram Babu Kasaragod, Dr. Linda Haugaard-Kedström, Dr. Torben Johann Hausrat, Prof. Dr. Matthias Kneussel, Prof. Dr. Hermann Schindelin and Prof. Dr. Kristian Strømgaard

Design and Synthesis of High-Affinity Dimeric Inhibitors Targeting the Interactions between Gephyrin and Inhibitory Neurotransmitter ReceptorsDouble-teaming: Dimeric peptide ligands were developed that target gephyrin, the central scaffolding protein for inhibitory neurotransmitter receptors in the brain, with unprecedented high affinity. Dimerization also substantially improved the serum stability, thus providing compounds with great promise for further studies of gephyrin–receptor interactions. The X-ray structure shows one of these peptides in complex with two monomers of the gephyrin E domain.

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November 21, 2014

Hot Paper: Asymmetric Dearomatization of β-Naphthols through an Amination Reaction Catalyzed by a Chiral Phosphoric Acid

Shou-Guo Wang, Dr. Qin Yin, Dr. Chun-Xiang Zhuo and Prof. Dr. Shu-Li You

Asymmetric Dearomatization of β-Naphthols through an Amination Reaction Catalyzed by a Chiral Phosphoric AcidUseful skeletons: An electrophilic amination reaction catalyzed by chiral phosphoric acid is the basis for a highly efficient asymmetric dearomatization of naphthols. This protocol provides functionalized β-naphthalenone compounds with a chiral quaternary carbon center in excellent yields and enantioselectivity. These motifs are found in various biologically active natural products and therapeutic reagents.

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November 21, 2014

Hot Paper: Metal-Free Carbonylations by Photoredox Catalysis

Ing. Michal Majek and Prof. Dr. Axel Jacobi von Wangelin

Metal-Free Carbonylations by Photoredox CatalysisA metal-free and base-free carbonylation has been developed which affords primary, secondary, and tertiary alkyl benzoates under irradiation with visible light in the presence of eosin Y as a photocatalyst. The mechanism has been studied by spectroscopic, theoretical, and preparative methods, and appears to involve intermediate aryl and aroyl radical species as well as a light-driven one-electron redox cycle without any sacrificial redox partner.

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November 21, 2014

VIP: Magnet Design by Integration of Layer and Chain Magnetic Systems in a π-Stacked Pillared Layer Framework

Hiroki Fukunaga and Prof. Dr. Hitoshi Miyasaka

Magnet Design by Integration of Layer and Chain Magnetic Systems in a π-Stacked Pillared Layer FrameworkA pillared layer framework (PLF) was used to rationally design and fabricate a long-range ordered magnet with a phase transition temperature (Tc) of 82 K by integrating two low-dimensional magnetic materials, namely a layer magnetic system and a one-dimensional columnar magnetic system. Furthermore, Tc increased linearly with the applied pressure.

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November 20, 2014

Hot Paper: Ionic Liquids: Not only Structurally but also Dynamically Heterogeneous

Zhuan-Ping Zheng, Prof. Wen-Hui Fan, Soham Roy, Dr. Kamila Mazur, Andreas Nazet, Prof. Richard Buchner, Prof. Mischa Bonn and Dr. Johannes Hunger

Ionic Liquids: Not only Structurally but also Dynamically HeterogeneousSize doesn′t matter: The equilibration of the ionic ammonium group in protic ionic liquids after an ultrafast temperature jump depends on the anion but not on the size of the hydrophobic side chain. This equilibration of the ionic domains is approximately two times slower than restructuring within the hydrophobic alkyl domains, which demonstrates the dynamic heterogeneity in ionic liquids.

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November 19, 2014

Angewandte Chemie 48/2014: Unexpected Synergy

Angewandte Chemie 48/2014: Unexpected SynergyThis week, D. P. Fairlie et al. review how to constrain cyclic peptides to mimic protein structure motifs. How does this lead to protease-resistant, potent and target-selective, biologically active compounds? In a Minireview, H. Mutlu and J.-F. Lutz discuss the sequencing of natural and synthetic macromolecules. The Highlights deal with the iron-catalyzed hydrogenation of esters to alcohols (J.-L. Renaud et al.) and protein crystallography with free-electron lasers (H. Ogata and W. Lubitz).

In the Communications section, T.-B. Lu et al. describe homogeneous electrocatalytic water oxidation at neutral pH by a nickel(II) complex (see picture). T. Taniguchi and D. P. Curran succeeded in the hydroboration of arynes with N-heterocyclic carbene boranes. B. P. T. Fokwa et al. found an unexpected synergy between magnetic iron chains and stacked B6 rings in a new ferromagnetic material. G. Gescheidt et al. investigated radicals from green-tea polyphenols and highly reactive oxygen species by time-resolved EPR spectroscopy.

Browse issue 48/2014 now.

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November 18, 2014

Hot Paper: Cobalt-Catalyzed C[BOND]H Cyanation of Arenes and Heteroarenes

M. Sc. Jie Li and Prof. Dr. Lutz Ackermann

Cobalt-Catalyzed C<img src="http://onlinelibrarystatic.wiley.com/undisplayable_characters/00f8ff.gif" alt="[BOND]" />H Cyanation of Arenes and HeteroarenesAs directed: The title reactions were accomplished with in situ generated cobalt(III) carboxylate complexes for highly efficient C[BOND]H activations. The direct cyanation proved viable with removable directing groups and displayed a broad substrate scope and mild reaction conditions.

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November 18, 2014

Hot Paper: Porous Liquids: A Promising Class of Media for Gas Separation

Dr. Jinshui Zhang, Dr. Song-Hai Chai, Dr. Zhen-An Qiao, Dr. Shannon M. Mahurin, Dr. Jihua Chen, Dr. Youxing Fang, Dr. Shun Wan, Kimberly Nelson, Dr. Pengfei Zhang and Prof. Sheng Dai

Porous Liquids: A Promising Class of Media for Gas SeparationPerforated liquids: Functionalizing hollow silica spheres with suitable polymer species can produce a porous liquid containing empty silica cavities. Taking advantage of their liquid-like polymeric matrixes as the separation medium and the empty cavities as the gas transport pathway they can function as a promising candidates for gas separation.

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November 18, 2014

Hot Paper: A Twist-Bend Nematic Phase Driven by Hydrogen Bonding

Suzanne M. Jansze, Dr. Alfonso Martínez-Felipe, Prof. John M. D. Storey, Dr. Antonius T. M. Marcelis and Prof. Corrie T. Imrie

A Twist-Bend Nematic Phase Driven by Hydrogen BondingIntriguing interplay: When the benzoic acid units in 4-[6-(4′-cyanobiphenyl-4-yl)hexyloxy]benzoic acid dimerize by hydrogen bonding (see picture), promesogenic liquid crystal trimers form. These supramolecular complexes show an enantiotropic nematic phase, which on cooling transforms into the twist-bend nematic phase in which the bent, achiral complexes spontaneously form helical structures.

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November 14, 2014

Hot Paper: Atomic-Resolution Three-Dimensional Structure of Amyloid β Fibrils Bearing the Osaka Mutation

Dr. Anne K. Schütz, Dr. Toni Vagt, Dr. Matthias Huber, Dr. Oxana Y. Ovchinnikova, Riccardo Cadalbert, Dr. Joseph Wall, Prof. Dr. Peter Güntert, Dr. Anja Böckmann, Prof. Dr. Rudi Glockshuber and Prof. Dr. Beat H. Meier

Atomic-Resolution Three-Dimensional Structure of Amyloid β Fibrils Bearing the Osaka MutationA fold not observed before: The atomic-resolution fibril structure of the Aβ1-40 peptide with the Osaka mutation (E22Δ), which is associated with early-onset Alzheimer's disease, differs substantially from all previously proposed models. In this complex structure the deletion mutation is found in a β turn.

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November 14, 2014

Hot Paper: Benzoxazolone Carboxamides: Potent and Systemically Active Inhibitors of Intracellular Acid Ceramidase

Dr. Daniela Pizzirani, Dr. Anders Bach, Dr. Natalia Realini, Dr. Andrea Armirotti, Dr. Luisa Mengatto, Dr. Inga Bauer, Dr. Stefania Girotto, Dr. Chiara Pagliuca, Dr. Marco De Vivo, Dr. Maria Summa, Dr. Alison Ribeiro and Prof. Daniele Piomelli

Benzoxazolone Carboxamides: Potent and Systemically Active Inhibitors of Intracellular Acid CeramidaseA key regulator of the sphingolipid metabolism is acid ceramidase (AC), which offers a molecular target in disorders such as cancer and inflammation, in which sphingolipid signaling might be dysfunctional. The shown compound is metabolically stable, inhibits AC activity both in vitro and in vivo, and can thus be used as a potent chemical probe to investigate the roles of ceramides in physiology and pathology.

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November 14, 2014

Hot Paper: Construction of Matryoshka-Type Structures from Supercharged Protein Nanocages

Dr. Tobias Beck, Stephan Tetter, Matthias Künzle and Prof. Dr. Donald Hilvert

Construction of Matryoshka-Type Structures from Supercharged Protein NanocagesCages within cages: By exploiting electrostatic interactions between two supercharged protein containers, namely supercharged lumazine synthase (red) and supercharged ferritin (blue) loaded with iron-oxide nanoparticles (black), nested Matryoshka-type structures were assembled. These cage-within-cage structures consist of two layers of protein surrounding iron oxide nanoparticles in a manner reminiscent of Russian dolls.

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November 21, 2014
Hot Paper: Design and Synthesis of High-Affinity Dimeric Inhibitors Targeting the Interactions between Gephyrin and Inhibitory Neurotransmitter Receptors

November 21, 2014
Hot Paper: Asymmetric Dearomatization of β-Naphthols through an Amination Reaction Catalyzed by a Chiral Phosphoric Acid

November 21, 2014
Hot Paper: Metal-Free Carbonylations by Photoredox Catalysis

November 21, 2014
VIP: Magnet Design by Integration of Layer and Chain Magnetic Systems in a π-Stacked Pillared Layer Framework

November 20, 2014
Hot Paper: Ionic Liquids: Not only Structurally but also Dynamically Heterogeneous

November 19, 2014
Angewandte Chemie 48/2014: Unexpected Synergy

November 18, 2014
Hot Paper: Cobalt-Catalyzed C[BOND]H Cyanation of Arenes and Heteroarenes

November 18, 2014
Hot Paper: Porous Liquids: A Promising Class of Media for Gas Separation

November 18, 2014
Hot Paper: A Twist-Bend Nematic Phase Driven by Hydrogen Bonding

November 14, 2014
Hot Paper: Atomic-Resolution Three-Dimensional Structure of Amyloid β Fibrils Bearing the Osaka Mutation

November 14, 2014
Hot Paper: Benzoxazolone Carboxamides: Potent and Systemically Active Inhibitors of Intracellular Acid Ceramidase

November 14, 2014
Hot Paper: Construction of Matryoshka-Type Structures from Supercharged Protein Nanocages

November 13, 2014
Angewandte Chemie 47/2014: Molecular Machinery

November 12, 2014
Hot Paper: Green-Solvent-Processed Molecular Solar Cells

November 12, 2014
Hot Paper: Boron as a Powerful Reductant: Synthesis of a Stable Boron-Centered Radical-Anion Radical-Cation Pair

November 11, 2014
VIP: An Efficient Nanoscale Heterogeneous Catalyst for the Capture and Conversion of Carbon Dioxide at Ambient Pressure

November 08, 2014
Hot Paper: Graphitic Carbon Nitride Nanoribbons: Graphene-Assisted Formation and Synergic Function for Highly Efficient Hydrogen Evolution

November 07, 2014
Hot Paper: Ligand-Controlled Regiodivergent Nickel-Catalyzed Annulation of Pyridones

November 07, 2014
Hot Paper: Electron-Driven Self-Assembly of Salt Nanocrystals in Liquid Helium

November 07, 2014
Hot Paper: Rapid and Efficient Copper-Catalyzed Finkelstein Reaction of (Hetero)Aromatics under Continuous-Flow Conditions

November 07, 2014
Hot Paper: Aerobic Palladium-Catalyzed Dioxygenation of Alkenes Enabled by Catalytic Nitrite

November 06, 2014
Hot Paper: A Systems Approach towards an Intelligent and Self-Controlling Platform for Integrated Continuous Reaction Sequences

November 06, 2014
Hot Paper: Frustrated Lewis Pair Activation of an N-Sulfinylamine: A Source of Sulfur Monoxide

November 05, 2014
Hot Paper: Two-Coordinate Iron(I) Complex [Fe{N(SiMe3)2}2]: Synthesis, Properties, and Redox Activity

November 05, 2014
Hot Paper: Sonocrystallization Yields Monoclinic Paracetamol with Significantly Improved Compaction Behavior

November 04, 2014
VIP: Inducing Axial Chirality in a “Geländer” Oligomer by Length Mismatch of the Oligomer Strands

November 01, 2014
VIP: A Multiply Functionalized Base-Coordinated GeII Compound and Its Reversible Dimerization to the Digermene

October 31, 2014
Hot Paper: Molybdenum Phosphosulfide: An Active, Acid-Stable, Earth-Abundant Catalyst for the Hydrogen Evolution Reaction

October 31, 2014
Hot Paper: Flexible and Stretchable Lithium-Ion Batteries and Supercapacitors Based on Electrically Conducting Carbon Nanotube Fiber Springs

October 31, 2014
Hot Paper: “Photoclick” Postsynthetic Modification of DNA

October 31, 2014
VIP: Transparent Metal Selenide Alloy Counter Electrodes for High-Efficiency Bifacial Dye-Sensitized Solar Cells

October 29, 2014
Angewandte Chemie 45/2014: Mechanics and Chemistry

October 28, 2014
Hot Paper: Copper-Catalyzed Asymmetric Synthesis of Tertiary α-Hydroxy Phosphonic Acid Derivatives with In Situ Generated Nitrosocarbonyl Compounds as the Oxygen Source

October 28, 2014
VIP: Identification and Accurate Size Characterization of Nanoparticles in Complex Media

October 25, 2014
Hot Paper: Synthesis, Structure, and Frequency-Doubling Effect of Calcium Cyanurate

October 24, 2014
Hot Paper: Practical and Highly Selective C[BOND]H Functionalization of Structurally Diverse Ethers

October 24, 2014
Hot Paper: Combining Topology and Sequence Design for the Discovery of Potent Antimicrobial Peptide Dendrimers against Multidrug-Resistant Pseudomonas aeruginosa

October 24, 2014
Hot Paper: In Situ Vesicle Formation by Native Chemical Ligation

October 24, 2014
Hot Paper: Hydroboration of Arynes with N-Heterocyclic Carbene Boranes

October 24, 2014
VIP: Breathing Pores on Command: Redox-Responsive Spongy Membranes from Poly(ferrocenylsilane)s

October 23, 2014
Hot Paper: Capturing the Mechanical Unfolding Pathway of a Large Protein with Coiled-Coil Probes

October 21, 2014
Hot Paper: An Efficient Method for the In Vitro Production of Azol(in)e-Based Cyclic Peptides

October 21, 2014
Hot Paper: Excellent Stability of a Lithium-Ion-Conducting Solid Electrolyte upon Reversible Li+/H+ Exchange in Aqueous Solutions

October 21, 2014
Hot Paper: Polyoxometalate Ionic Liquids as Self-Repairing Acid-Resistant Corrosion Protection

October 21, 2014
VIP: Scanning Electrochemical Microscopy of Individual Catalytic Nanoparticles

October 17, 2014
Hot Paper: Total Synthesis of the Tetracyclic Antimalarial Alkaloid (±)-Myrioneurinol

October 17, 2014
Hot Paper: A Cascade Strategy Enables a Total Synthesis of (−)-Gephyrotoxin

October 16, 2014
Hot Paper: The Structure and Stability of Magic Carbon Clusters Observed in Graphene Chemical Vapor Deposition Growth on Ru(0001) and Rh(111) Surfaces

October 16, 2014
Hot Paper: Metal–Organic Frameworks for Oxygen Storage

October 16, 2014
VIP: Ruthenium–Porphyrin-Catalyzed Diastereoselective Intramolecular Alkyl Carbene Insertion into C[BOND]H Bonds of Alkyl Diazomethanes Generated In Situ from N-Tosylhydrazones

October 15, 2014
Hot Paper: Photocaged DNAzymes as a General Method for Sensing Metal Ions in Living Cells

October 15, 2014
Hot Paper: A Complete Switch of the Directional Selectivity in the Annulation of 2-Hydroxybenzaldehydes with Alkynes

October 15, 2014
Hot Paper: Organocatalytic and Scalable Synthesis of the Anti-Influenza Drugs Zanamivir, Laninamivir, and CS-8958

October 15, 2014
Hot Paper: Direct Evidence for a Peroxide Intermediate and a Reactive Enzyme–Substrate–Dioxygen Configuration in a Cofactor-free Oxidase

October 15, 2014
Hot Paper: Identification of Bacteria in Water by a Fluorescent Array

October 15, 2014
Hot Paper: A Molecular Copper Catalyst for Electrochemical Water Reduction with a Large Hydrogen-Generation Rate Constant in Aqueous Solution

October 15, 2014
VIP: Preparation of Stereoregular Isotactic Poly(mandelic acid) through Organocatalytic Ring-Opening Polymerization of a Cyclic O-Carboxyanhydride

October 08, 2014
Nobel Prize in Chemistry 2014: Super Resolution

October 08, 2014
Hot Paper: Membrane-Spanning DNA Nanopores with Cytotoxic Effect

September 10, 2014
Angewandte Chemie 38/2014: Nobel Chemistry

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