Angewandte Chemie International Edition

Cover image for Vol. 55 Issue 7

Chefredakteur: Peter Gölitz, Stellvertreter: Neville Compton, Haymo Ross

Online ISSN: 1521-3773

Associated Title(s): Angewandte Chemie, Chemistry - A European Journal, Chemistry – An Asian Journal, ChemistryOpen, ChemPlusChem, Zeitschrift für Chemie

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February 05, 2016

Hot Paper: Catalytic SN2′- and Enantioselective Allylic Substitution with a Diborylmethane Reagent and Application in Synthesis

Ying Shi and Prof. Amir H. Hoveyda

Catalytic SN2′- and Enantioselective Allylic Substitution with a Diborylmethane Reagent and Application in Synthesis

Combination catalysis: The first examples of catalytic enantioselective allylic substitution reactions that introduce a CH2−B(pin) unit are described (pin=pinacolato). In combination with various catalytic cross-coupling processes, a range of important organic molecules are now readily accessible.

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February 04, 2016

Angewandte Chemie 7/2016: Beneath the Surface

Angewandte Chemie 7/2016: Beneath the SurfaceIn this issue, J. G. C. Veinot et al. review the synthesis, surface engineering, and applications of silicon nanocrystals and silicon–polymer hybrids. How did silicon enter the field of quantum dots? In a Minireview, S. Wang and X. Wang summarize recent work on imidazolate building blocks for CO2 capture and photochemical reduction. The Highlight deals with a chiral metal photocatalyst's architecture (A. G. Amador and T. P. Yoon).

In the Communications section, R. Antoine et al. report on the mass determination of entire amyloid fibrils by using mass spectrometry (see picture). B. G. Davis et al. describe an optimal synthetic glycosylation of a therapeutic antibody. L. Gan et al. show how selective multiamination of C70 leads to curved π systems, and P. J. Walsh et al. succeeded in palladium-catalyzed asymmetric allylic alkylations with toluene pronucleophiles.

Browse issue 7/2016 now.

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February 03, 2016

Hot Paper: Synthesis of Nitrogen-Containing Rubicene and Tetrabenzopentacene Derivatives

Dr. Young S. Park, Dr. David J. Dibble, Dr. Juhwan Kim, Robert C. Lopez, Eriberto Vargas and Prof. Alon A. Gorodetsky

Synthesis of Nitrogen-Containing Rubicene and Tetrabenzopentacene Derivatives

Variants of classic polycyclic aromatic hydrocarbons: Nitrogen-containing rubicenes and tetrabenzopentacenes were prepared via a straightforward approach. The reported synthetic method may enable the development of electron transporting organic semiconductors and the eventual construction of larger carbonaceous systems.

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February 03, 2016

Angewandte Chemie 6/2016: Mild and Aromatic

Angewandte Chemie 6/2016: Mild and AromaticIn this issue, P. D. Beer et al. review anion recognition in water. What are recent advances from a supramolecular or macromolecular perspective? In a Minireview, M. Toure and C. M. Crews discuss small-molecule proteolysis-targeting chimeras for protein degradation. The Highlight deals with light Hückel-aromatic boron compounds (B. Wrackmeyer).

In the Communications section, Z. Novák et al. present a mild and efficient direct trifluoroethylation of aromatic systems (see picture). M. Schmittel et al. found that conformational slippage determines the rotational frequency in five-component nanorotors. D. G. Nocera et al. reveal the electronic structure of copper corroles, and X. Tang et al. succeeded in the photochemical regulation of gene expression using caged vitamin E modified siRNAs.

Browse issue 6/2016 now.

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January 29, 2016

Hot Paper: Pyridyl Pyrrolide Boron Complexes: The Facile Generation of Thermally Activated Delayed Fluorescence and Preparation of Organic Light-Emitting Diodes

Yi-Jiun Shiu, Yung-Chen Cheng, Wei-Lung Tsai, Prof. Chung-Chih Wu, Chun-Tien Chao, Dr. Chin-Wei Lu, Prof. Yun Chi, Yi-Ting Chen, Dr. Shih-Hung Liu and Prof. Pi-Tai Chou

Pyridyl Pyrrolide Boron Complexes: The Facile Generation of Thermally Activated Delayed Fluorescence and Preparation of Organic Light-Emitting Diodes

Reducing the gap: Using a boron atom as the spiro linker between an electron-deficient pyridyl pyrrolide and an electron-donating phenylcarbazolyl or triphenylamine fragment, boron complexes with a narrow HOMO–LUMO orbital overlap, small singlet–triplet energy gap (down to 38 meV), and strong thermally activated delayed fluorescence (TADF) were prepared. For the first time boron-complex-based OLEDs show a significant TADF contribution.

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January 29, 2016

Hot Paper: Giant Amplification of Photoswitching by a Few Photons in Fluorescent Photochromic Organic Nanoparticles

Dr. Jia Su, Prof. Tuyoshi Fukaminato, Dr. Jean-Pierre Placial, Dr. Tsunenobu Onodera, Ryuju Suzuki, Prof. Hidetoshi Oikawa, Arnaud Brosseau, Dr. François Brisset, Dr. Robert Pansu, Prof. Keitaro Nakatani and Dr. Rémi Métivier

Giant Amplification of Photoswitching by a Few Photons in Fluorescent Photochromic Organic Nanoparticles

Amped up: Fluorescent photochromic organic nanoparticles, showing bright red emission, complete ON–OFF contrast with full reversibility, and excellent fatigue resistance, have been prepared. They exhibit a full fluorescence quenching and recovery under light illumination at very low photochromic conversion levels, leading to a “giant amplification of fluorescence photoswitching”.

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January 29, 2016

Hot Paper: A General Strategy for the Nickel-Catalyzed C−H Alkylation of Anilines

Zhixiong Ruan, Sebastian Lackner and Prof. Dr. Lutz Ackermann

A General Strategy for the Nickel-Catalyzed C−H Alkylation of Anilines

One for all: An inexpensive nickel catalyst enables the C−H alkylation of pyrimidyl anilines with both primary and secondary alkyl halides. The directing group (DG) could be easily removed in a traceless fashion, and the products contain key structural motifs of important anticancer drugs.

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January 29, 2016

Hot Paper: Single-Molecule Nanocatalysis Shows In Situ Deactivation of Pt/C Electrocatalysts during the Hydrogen-Oxidation Reaction

Dr. Yuwei Zhang, Tao Chen, Dr. Shaun Alia, Prof. Bryan S. Pivovar and Prof. Dr. Weilin Xu

Single-Molecule Nanocatalysis Shows In Situ Deactivation of Pt/C Electrocatalysts during the Hydrogen-Oxidation Reaction

Catalyst deactivation: By combining single-molecule nanocatalysis with traditional electrochemical methods, the kinetics of the deactivation of a Pt/C electrocatalyst at single-particle level was studied during electrocatalytic hydrogen-oxidation reaction. A correlation between stability and deactivation of the PT/C catalyst was shown.

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January 29, 2016

Hot Paper: Reductive Cyclopropanations Catalyzed by Dinuclear Nickel Complexes

Dr. You-Yun Zhou and Prof. Christopher Uyeda

Reductive Cyclopropanations Catalyzed by Dinuclear Nickel Complexes

Nickel interplay: Dinuclear nickel complexes (see scheme) catalyze the reductive cyclopropanation of alkenes with CH2Cl2 as the methylene source and Zn or Et2Zn as the terminal reductant. Diverse alkenes bearing common functional groups are tolerated under the mildly reducing reaction conditions.

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January 29, 2016

Hot Paper: Combining Biomimetic Block Copolymer Worms with an Ice-Inhibiting Polymer for the Solvent-Free Cryopreservation of Red Blood Cells

Daniel E. Mitchell, Joseph R. Lovett, Prof. Dr. Steven P. Armes and Dr. Matthew I. Gibson

Combining Biomimetic Block Copolymer Worms with an Ice-Inhibiting Polymer for the Solvent-Free Cryopreservation of Red Blood Cells

Antifreeze-free freezing: A wholly synthetic, solvent-free approach for cellular cryopreservation is based on the use of biomimetic block copolymer worms in combination with a well-known ice-recrystallization inhibitor, poly(vinyl alcohol). Upon thawing, red-blood-cell recoveries of up to 70 % were achieved, and free-standing hydrogels were obtained by warming to ambient temperature.

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January 29, 2016

Hot Paper: Rapid Determination of Fast Protein Dynamics from NMR Chemical Exchange Saturation Transfer Data

Yina Gu, Dr. Alexandar L. Hansen, Dr. Yu Peng and Prof. Dr. Rafael Brüschweiler

Rapid Determination of Fast Protein Dynamics from NMR Chemical Exchange Saturation Transfer Data

An integrated protocol is reported for the rapid measurement of longitudinal and transverse spin relaxation parameters of proteins using chemical exchange saturation transfer experiments (CEST; see picture). The experiments are suitable for quantitative interpretation by a lean model-free approach (Lean MFA).

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January 29, 2016

Hot Paper: Directly Diphenylborane-Fused Porphyrins

Keisuke Fujimoto, Juwon Oh, Prof. Dr. Hideki Yorimitsu, Prof. Dr. Dongho Kim and Prof. Dr. Atsuhiro Osuka

Directly Diphenylborane-Fused Porphyrins

A clear expansive π: Diphenylborane-fused porphyrins were synthesized from the corresponding β-(2-trimethylsilylphenyl)-substituted porphyrins. The porphyrin π-system interacts with the vacant p-orbital of the boron. Pyridine adds at the boron center erasing the electronic interaction.

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February 05, 2016
Hot Paper: Catalytic SN2′- and Enantioselective Allylic Substitution with a Diborylmethane Reagent and Application in Synthesis

February 04, 2016
Angewandte Chemie 7/2016: Beneath the Surface

February 03, 2016
Hot Paper: Synthesis of Nitrogen-Containing Rubicene and Tetrabenzopentacene Derivatives

February 03, 2016
Angewandte Chemie 6/2016: Mild and Aromatic

January 29, 2016
Hot Paper: Pyridyl Pyrrolide Boron Complexes: The Facile Generation of Thermally Activated Delayed Fluorescence and Preparation of Organic Light-Emitting Diodes

January 29, 2016
Hot Paper: Giant Amplification of Photoswitching by a Few Photons in Fluorescent Photochromic Organic Nanoparticles

January 29, 2016
Hot Paper: A General Strategy for the Nickel-Catalyzed C−H Alkylation of Anilines

January 29, 2016
Hot Paper: Single-Molecule Nanocatalysis Shows In Situ Deactivation of Pt/C Electrocatalysts during the Hydrogen-Oxidation Reaction

January 29, 2016
Hot Paper: Reductive Cyclopropanations Catalyzed by Dinuclear Nickel Complexes

January 29, 2016
Hot Paper: Combining Biomimetic Block Copolymer Worms with an Ice-Inhibiting Polymer for the Solvent-Free Cryopreservation of Red Blood Cells

January 29, 2016
Hot Paper: Rapid Determination of Fast Protein Dynamics from NMR Chemical Exchange Saturation Transfer Data

January 29, 2016
Hot Paper: Directly Diphenylborane-Fused Porphyrins

January 29, 2016
VIP: A Triatomic Silicon(0) Cluster Stabilized by a Cyclic Alkyl(amino) Carbene

January 29, 2016
VIP: Enzyme Selectivity Fine-Tuned through Dynamic Control of a Loop

January 29, 2016
VIP: Layered Black Phosphorus: Strongly Anisotropic Magnetic, Electronic, and Electron-Transfer Properties

January 29, 2016
VIP: Superparamagnetic Reduced Graphene Oxide with Large Magnetoresistance: A Surface Modulation Strategy

January 29, 2016
VIP: Elemental-Sulfur-Mediated Facile Synthesis of a Covalent Triazine Framework for High-Performance Lithium–Sulfur Batteries

January 26, 2016
Hot Paper: Traceless Synthesis of Asymmetrically Modified Bivalent Nucleosomes

January 26, 2016
VIP: Cooperative Reductive Elimination: The Missing Piece in the Oxidative-Coupling Mechanistic Puzzle

January 25, 2016
Hot Paper: Chemoproteomics-Enabled Discovery of a Potent and Selective Inhibitor of the DNA Repair Protein MGMT

January 25, 2016
Hot Paper: Trimerization of the HIV Transmembrane Domain in Lipid Bilayers Modulates Broadly Neutralizing Antibody Binding

January 25, 2016
Hot Paper: Ca2+-Induced Oxidation Generation by FeO42− at pH 910

January 25, 2016
VIP: Light-Harvesting Systems Based on Organic Nanocrystals To Mimic Chlorosomes

January 25, 2016
VIP: Noninvasive Staging of Kidney Dysfunction Enabled by Renal-Clearable Luminescent Gold Nanoparticles

January 25, 2016
VIP: Total Synthesis of Ileabethoxazole, Pseudopteroxazole, and seco-Pseudopteroxazole

January 22, 2016
Angewandte Chemie 5/2016: Sweet Chemistry

January 22, 2016
VIP: Catalytically Active Rh Sub-Nano Clusters on TiO2 for CO Oxidation at Cryogenic Temperatures

January 19, 2016
Angewandte Chemie 4/2016: Go with the Flow

January 15, 2016
Hot Paper: Tandem Allylboration–Prins Reaction for the Rapid Construction of Substituted Tetrahydropyrans: Application to the Total Synthesis of (−)-Clavosolide A

January 15, 2016
VIP: Filtration Shell Mediated Power Density Independent Orthogonal Excitations–Emissions Upconversion Luminescence

January 13, 2016
Angewandte Chemie 3/2016: Psychedelic

January 13, 2016
Hot Paper: Electroresponsive Structurally Colored Materials: A Combination of Structural and Electrochromic Effects

January 13, 2016
Hot Paper: Visualization of Protein-Specific Glycosylation inside Living Cells

January 11, 2016
Hot Paper: Recognition and Sensing of Creatinine

January 11, 2016
Hot Paper: Hypercrosslinked Additives for Ageless Gas-Separation Membranes

January 11, 2016
VIP: Target-induced and Equipment-free DNA Amplification with a Simple Paper Device

January 08, 2016
Hot Paper: ATP-Releasing Nucleotides: Linking DNA Synthesis to Luciferase Signaling

January 08, 2016
Hot Paper: Graphene Oxide Catalyzed C[BOND]H Bond Activation: The Importance of Oxygen Functional Groups for Biaryl Construction

January 08, 2016
VIP: First Principles Calculations for Hydrogenation of Acrolein on Pd and Pt: Chemoselectivity Depends on Steric Effects on the Surface

January 08, 2016
VIP: Synthesis of Iron Nanometallic Glasses and Their Application in Cancer Therapy by a Localized Fenton Reaction

January 08, 2016
VIP: Electrocatalytic Generation of Amidyl Radicals for Olefin Hydroamidation: Use of Solvent Effects to Enable Anilide Oxidation

January 08, 2016
VIP: Oxyhydroxide Nanosheets with Highly Efficient Electron–Hole Pair Separation for Hydrogen Evolution

December 29, 2015
Hot Paper: Single-Atom Catalyst of Platinum Supported on Titanium Nitride for Selective Electrochemical Reactions

December 29, 2015
VIP: N,P-Codoped Carbon Networks as Efficient Metal-free Bifunctional Catalysts for Oxygen Reduction and Hydrogen Evolution Reactions

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