Angewandte Chemie International Edition

Cover image for Vol. 54 Issue 36

Editor: Peter Gölitz, Deputy Editors: Neville Compton, Haymo Ross

Online ISSN: 1521-3773

Associated Title(s): Angewandte Chemie, Chemistry - A European Journal, Chemistry – An Asian Journal, ChemistryOpen, ChemPlusChem, Zeitschrift für Chemie

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August 28, 2015

Hot Paper: Enzymatic Prenylation and Oxime Ligation for the Synthesis of Stable and Homogeneous Protein–Drug Conjugates for Targeted Therapy

Dr. Joong-jae Lee, Hyo-Jung Choi, Misun Yun, YingJin Kang, Ji-Eun Jung, Dr. Yiseul Ryu, Tae Yoon Kim, Young-je Cha, Prof. Hyun-Soo Cho, Prof. Jung-Joon Min, Dr. Chul-Woong Chung and Prof. Hak-Sung Kim

Enzymatic Prenylation and Oxime Ligation for the Synthesis of Stable and Homogeneous Protein–Drug Conjugates for Targeted TherapyA chemoenzymatic conjugation method that is based on enzymatic prenylation and oxime ligation is a simple and efficient means for generating highly stable and homogeneous protein–drug conjugates in a site-specific manner. It can be generally applied to the conjugation of drugs to a wide range of protein binders, facilitating the development of targeted therapies with high efficacies and low off-target effects.

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August 28, 2015

Hot Paper: Stability of Fe-N-C Catalysts in Acidic Medium Studied by Operando Spectroscopy

Dr. Chang Hyuck Choi, Claudio Baldizzone, Jan-Philipp Grote, Dr. Anna K. Schuppert, Dr. Frédéric Jaouen and Dr. Karl J. J. Mayrhofer

Stability of Fe-N-C Catalysts in Acidic Medium Studied by Operando SpectroscopyThe stable potential window of Fe-N-C catalysts for oxygen reduction reactions is studied using a scanning flow cell equipped with advanced online analytical techniques. Fe demetalation and carbon oxidation (see picture) are observed in low (<0.7 V) and high (>0.9 V) potential regions, respectively, which can introduce significant performance drops in a fuel cell.

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August 28, 2015

Hot Paper: Whole-Genome Sequencing of a Single Viral Species from a Highly Heterogeneous Sample

Dr. Hee-Sun Han, Paul G. Cantalupo, Dr. Assaf Rotem, Dr. Shelley K. Cockrell, Martial Carbonnaux, Prof. James M. Pipas and Prof. David A. Weitz

Whole-Genome Sequencing of a Single Viral Species from a Highly Heterogeneous SampleOn a drop-in basis: A new platform that integrates drop-based microfluidics and computational analysis was developed for purification of a single viral species from a mixed sample and retrieval of its complete genome sequence. This method was used to retrieve the genome sequence of SV40 spiked into wastewater with more than 96 % sequence coverage and 99.8 % sequence identity. The platform can also be used to detect and identify unknown viruses.

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August 28, 2015

Hot Paper: Periodic Mesoporous Organosilica with Molecular-Scale Ordering Self-Assembled by Hydrogen Bonds

Dr. Norihiro Mizoshita and Dr. Shinji Inagaki

Periodic Mesoporous Organosilica with Molecular-Scale Ordering Self-Assembled by Hydrogen BondsHost–guest systems: Self-assembly of an organosilane precursor by hydrogen bonding is the key to construction of a new class of crystal-like periodic mesoporous organosilicas (see picture). The present mesoporous materials can stably accomodate silane-free H-bonding guest molecules within the pore walls, which is applicable to non-covalent modification of organosilica hybrids.

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August 28, 2015

Hot Paper: Self-Assembled DNA Nanoclews for the Efficient Delivery of CRISPR–Cas9 for Genome Editing

Wujin Sun, Wenyan Ji, Jordan M. Hall, Quanyin Hu, Dr. Chao Wang, Prof. Dr. Chase L. Beisel and Prof. Dr. Zhen Gu

Self-Assembled DNA Nanoclews for the Efficient Delivery of CRISPR–Cas9 for Genome EditingAll rolled into one: A biologically inspired delivery vehicle for CRISPR–Cas9 is based on yarn-like DNA nanoparticles that are synthesized by rolling circle amplification. The DNA nanoclews were efficiently loaded with Cas9 protein/single guide RNA complexes and delivered them into human cells, enabling targeted gene disruption.

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August 27, 2015

Angewandte Chemie 36/2015: Material, Heal Thyself

Angewandte Chemie 36/2015: Material, Heal ThyselfIn this issue, S. R. White et al. review biomimetic self-healing. How did scientists, inspired by nature, create synthetic materials that can regenerate their mechanical integrity and specific functions after damage? In a Minireview, I. J. S. Fairlamb discusses redox-active NOx ligands in palladium-mediated reactions. The Highlights deal with microbes living in human bodies (H. B. Bode) and iterative synthesis (J. Hartwig and A. Kirschning).

In the Communications section, C. J. Yang et al. demonstrate how to translate molecular recognition into a pressure signal to enable portable biomedical analysis (see picture). L. S. Cederbaum et al. describe a barrierless single-electron-induced cis-trans isomerization. P. Chen et al. succeeded in nickel-catalyzed cyclopropanation reactions with NMe4OTf and n-BuLi, and C. A. Seipp et al. report on aqueous sulfate separation by crystallization of sulfate–water clusters.

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August 27, 2015

Hot Paper: Synthesis, Structure, and Properties of SrC(NH)3, a Nitrogen-Based Carbonate Analogue with the Trinacria Motif

M. Sc. Ronja Missong, M. Sc. Janine George, Dr. Andreas Houben, Dr. Markus Hoelzel and Prof. Dr. Richard Dronskowski

Synthesis, Structure, and Properties of SrC(NH)3, a Nitrogen-Based Carbonate Analogue with the Trinacria MotifKeeping an ion guanidinate: Strontium guanidinate, SrC(NH)3, the first compound with a doubly deprotonated guanidine unit, was synthesized, and its properties investigated using X-ray and neutron powder diffraction as well as IR spectroscopy. Combined with quantum-theoretical calculations, allows a qualitative and quantitative discussion some first insights into the structure of the anionic guanidine unit.

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August 27, 2015

Hot Paper: Site-Directed, On-Surface Assembly of DNA Nanostructures

Dr. Rebecca Meyer, Dr. Barbara Saccà and Prof. Dr. Christof M. Niemeyer

Site-Directed, On-Surface Assembly of DNA NanostructuresFrom micro to nano: Orthogonal topographic modification of planar DNA nanostructures combined with site-directed on-surface assembly provides a means to bridge top-down micropatterning with bottom-up nanotechnology.

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August 27, 2015

Hot Paper: Large-Area, Free-Standing, Two-Dimensional Supramolecular Polymer Single-Layer Sheet for Highly Efficient Electrocatalytic Hydrogen Evolution

Dr. Renhao Dong, Martin Pfeffermann, Dr. Haiwei Liang, Dr. Zhikun Zheng, Dr. Xiang Zhu, Dr. Jian Zhang and Prof. Dr. Xinliang Feng

Large-Area, Free-Standing, Two-Dimensional Supramolecular Polymer Single-Layer Sheet for Highly Efficient Electrocatalytic Hydrogen EvolutionStanding up: The Langmuir–Blodgett method can be used to prepare two-dimensional supramolecular polymer (2DSP) sheets from nickel bis(dithiolene) complexes at the air–water interface (see figure). These free-standing single-layer sheets, which are 0.7–0.9 nm thick and square millimeters in area, showed excellent electrocatalytic activities in the hydrogen evolution reaction from water.

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August 26, 2015

VIP: Conductive Elastomers with Autonomic Self-Healing Properties

Kun Guo, Da-Li Zhang, Xiao-Mei Zhang, Prof. Dr. Jian Zhang, Prof. Dr. Li-Sheng Ding, Prof. Dr. Bang-Jing Li and Prof. Dr. Sheng Zhang

Conductive Elastomers with Autonomic Self-Healing PropertiesCandidates for smart robotics: Self-healing conductive composites were prepared by connecting single-walled carbon nanotubes (SWCNTs) to a polymer network through host–guest interactions (see picture). The poly(2-hydroxyethyl methacrylate)–SWCNT composite combines bulk electrical conductivity, proximity sensitivity, humidity sensitivity, and autonomic self-healing properties.

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August 24, 2015

Angewandte Chemie 35/2015: Doping

Angewandte Chemie 35/2015: DopingIn this issue, W. Schuhmann et al. review the role of metals in nitrogen-doped carbon electrocatalysts for oxygen reduction and R. J. Ingham et al. write on machine-assisted organic synthesis. In a Minireview, H. Schwarz discusses doping effects in cluster-mediated bond activation. The Highlights deal with small organoselenium compounds (T. Wirth) and diphosphatriazolates by click chemistry (C. Hering-Junghans, E. Rivard). In his Editorial, K. Müllen reflects on chemistry in a materials world, and E. R. Kay and D. A. Leigh debate the rise of the molecular machines in an Essay.

In the Communications section, S. A. Cirkel et al. describe frozen states of hydration of tert-butylamine (see picture). S. Ulrich et al. discovered a dynamic expression of DNA complexation with self-assembled clusters. J. Texter presents a model for exfoliation kinetics of layered materials, and H. Takezoe et al. found a twist-bend nematic phase of chiral materials.

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August 24, 2015

VIP: Orthogonal Light-Induced Self-Assembly of Nanoparticles using Differently Substituted Azobenzenes

Dr. Debasish Manna, Dr. Thumu Udayabhaskararao, Dr. Hui Zhao and Dr. Rafal Klajn

Orthogonal Light-Induced Self-Assembly of Nanoparticles using Differently Substituted AzobenzenesPrecise control of the assembly of selected components within complex mixtures is a challenging task. In their Communication (DOI: 10.1002/anie.201502419), R. Klajn et al. approach this challenge by decorating the surfaces of differently sized nanoparticles with two distinct azobenzenes that isomerize upon exposure to different wavelengths of light. The cover illustrates how ultraviolet and blue light can be used to selectively assemble large and small nanoparticles, respectively (Cover image: Ella Marushchenko).

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August 28, 2015
Hot Paper: Enzymatic Prenylation and Oxime Ligation for the Synthesis of Stable and Homogeneous Protein–Drug Conjugates for Targeted Therapy

August 28, 2015
Hot Paper: Stability of Fe-N-C Catalysts in Acidic Medium Studied by Operando Spectroscopy

August 28, 2015
Hot Paper: Whole-Genome Sequencing of a Single Viral Species from a Highly Heterogeneous Sample

August 28, 2015
Hot Paper: Periodic Mesoporous Organosilica with Molecular-Scale Ordering Self-Assembled by Hydrogen Bonds

August 28, 2015
Hot Paper: Self-Assembled DNA Nanoclews for the Efficient Delivery of CRISPR–Cas9 for Genome Editing

August 27, 2015
Angewandte Chemie 36/2015: Material, Heal Thyself

August 27, 2015
Hot Paper: Synthesis, Structure, and Properties of SrC(NH)3, a Nitrogen-Based Carbonate Analogue with the Trinacria Motif

August 27, 2015
Hot Paper: Site-Directed, On-Surface Assembly of DNA Nanostructures

August 27, 2015
Hot Paper: Large-Area, Free-Standing, Two-Dimensional Supramolecular Polymer Single-Layer Sheet for Highly Efficient Electrocatalytic Hydrogen Evolution

August 26, 2015
VIP: Conductive Elastomers with Autonomic Self-Healing Properties

August 24, 2015
Angewandte Chemie 35/2015: Doping

August 24, 2015
VIP: Orthogonal Light-Induced Self-Assembly of Nanoparticles using Differently Substituted Azobenzenes

August 22, 2015
Hot Paper: Metallic Single-Unit-Cell Orthorhombic Cobalt Diselenide Atomic Layers: Robust Water-Electrolysis Catalysts

August 22, 2015
Hot Paper: Synthesis of Silicate Zeolite Analogues Using Organic Sulfonium Compounds as Structure-Directing Agents

August 22, 2015
Hot Paper: Ultrasmall Black Phosphorus Quantum Dots: Synthesis and Use as Photothermal Agents

August 21, 2015
VIP: Observation of a Thermally Accessible Triplet State Resulting from Rotation around a Main-Group π Bond

August 20, 2015
Hot Paper: Attachment of Norovirus to Histo Blood Group Antigens: A Cooperative Multistep Process

August 19, 2015
Hot Paper: Aqueous Titanium Trichloride-Promoted Reductive Cyclization of o-Nitrostyrenes to Indoles: Development and Application to the Synthesis of Rizatriptan and Aspidospermidine

August 19, 2015
VIP: A High-Voltage and Ultralong-Life Sodium Full Cell for Stationary Energy Storage

August 15, 2015
Hot Paper: Hydrophosphination of CO2 and Subsequent Formate Transfer in the 1,3,2-Diazaphospholene-Catalyzed N-Formylation of Amines

August 15, 2015
Hot Paper: A Unique Ternary Semiconductor–(Semiconductor/Metal) Nano-Architecture for Efficient Photocatalytic Hydrogen Evolution

August 15, 2015
VIP: Time-Resolved Crystallography of the Reaction Intermediate of Nitrile Hydratase: Revealing a Role for the Cysteinesulfenic Acid Ligand as a Catalytic Nucleophile

August 15, 2015
VIP: Unusual H-bond Topology and Bifurcated H-bonds in the 2-Fluoroethanol Trimer

August 13, 2015
Hot Paper: Template Synthesis of Linear-Chain Nanodiamonds Inside Carbon Nanotubes from Bridgehead-Halogenated Diamantane Precursors

August 13, 2015
Hot Paper: [Cr(ddpd)2]3+: A Molecular, Water-Soluble, Highly NIR-Emissive Ruby Analogue

August 13, 2015
VIP: Selective Synthesis of Single- and Multi-Walled Supramolecular Nanotubes by Using Solvophobic/Solvophilic Controls: Stepwise Radial Growth via “Coil-on-Tube” Intermediates

August 13, 2015
VIP: Silver-Mediated Oxidative Trifluoromethylation of Phenols: Direct Synthesis of Aryl Trifluoromethyl Ethers

August 12, 2015
Hot Paper: Polymeric Micelle Assembly for the Smart Synthesis of Mesoporous Platinum Nanospheres with Tunable Pore Sizes

August 10, 2015
Angewandte Chemie 34/2015: Powering Chemistry

August 07, 2015
Hot Paper: The Methylsulfonyloxyl Radical, CH3SO3

August 07, 2015
Hot Paper: Chlorine-Free Red-Burning Pyrotechnics

August 07, 2015
Hot Paper: Thermosensitive Ion Channel Activation in Single Neuronal Cells by Using Surface-Engineered Plasmonic Nanoparticles

August 07, 2015
Hot Paper: Electrocatalytic Hydrogen Production by an Aluminum(III) Complex: Ligand-Based Proton and Electron Transfer

August 07, 2015
Hot Paper: Realizing both High Energy and High Power Densities by Twisting Three Carbon-Nanotube-Based Hybrid Fibers

August 07, 2015
VIP: Detection of the Short-Lived Radical Cation Intermediate in the Electrooxidation of N,N-Dimethylaniline by Mass Spectrometry

August 05, 2015
Hot Paper: Regioregular Synthesis of Azaborine Oligomers and a Polymer with a syn Conformation Stabilized by N[BOND]H⋅⋅⋅π Interactions

August 04, 2015
Angewandte Chemie 33/2015: A Long and Rich History

August 01, 2015
Hot Paper: Systemic Fluorescence Imaging of Zebrafish Glycans with Bioorthogonal Chemistry

August 01, 2015
VIP: Finely Tuned Polymer Interlayers Enhance Solar Cell Efficiency

July 31, 2015
Hot Paper: {μ-PbSe}: A Heavy CO Homologue as an Unexpected Ligand

July 31, 2015
Hot Paper: A Simple and Efficient Preparation of High-Purity Hydrogen Trioxide (HOOOH)

July 31, 2015
Hot Paper: Pentafulvene for the Synthesis of Complex Natural Products: Total Syntheses of (±)-Pallambins A and B

July 31, 2015
VIP: Highly Ordered Nanoporous Films from Supramolecular Diblock Copolymers with Hydrogen-Bonding Junctions

July 30, 2015
Hot Paper: Multi-Compartmental Hydrogel Microparticles Fabricated by Combination of Sequential Electrospinning and Photopatterning

July 30, 2015
Hot Paper: Electrostatic Localization of RNA to Protocell Membranes by Cationic Hydrophobic Peptides

July 30, 2015
Hot Paper: Metallic Single-Unit-Cell Orthorhombic Cobalt Diselenide Atomic Layers: Robust Water-Electrolysis Catalysts

July 30, 2015
VIP: Palladium-Catalyzed Decarbonylative Dehydration for the Synthesis of α-Vinyl Carbonyl Compounds and Total Synthesis of (−)-Aspewentins A, B, and C

July 25, 2015
Hot Paper: Chemical Synthesis Elucidates the Immunological Importance of a Pyruvate Modification in the Capsular Polysaccharide of Streptococcus pneumoniae Serotype 4

July 24, 2015
Hot Paper: Waterproof Alkyl Phosphate Coated Fluoride Phosphors for Optoelectronic Materials

July 24, 2015
Hot Paper: Rattling in the Quadruple Perovskite CuCu3V4O12

July 24, 2015
Hot Paper: Pushing the Limits of Neutral Organic Electron Donors: A Tetra(iminophosphorano)-Substituted Bispyridinylidene

July 24, 2015
VIP: Self-Pillared, Single-Unit-Cell Sn-MFI Zeolite Nanosheets and Their Use for Glucose and Lactose Isomerization

July 22, 2015
Hot Paper: A Small-Molecule Probe for Selective Profiling and Imaging of Monoamine Oxidase B Activities in Models of Parkinson’s Disease

July 22, 2015
Hot Paper: Rechargeable Hydrogen Storage System Based on the Dehydrogenative Coupling of Ethylenediamine with Ethanol

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