Angewandte Chemie International Edition

Cover image for Vol. 56 Issue 10

Editor: Peter Gölitz, Deputy Editors: Neville Compton, Haymo Ross

Online ISSN: 1521-3773

Associated Title(s): Angewandte Chemie, Chemistry - A European Journal, Chemistry – An Asian Journal, ChemistryOpen, ChemPhotoChem, ChemPlusChem, Zeitschrift für Chemie

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February 27, 2017

VIP: Iridium-Catalyzed Reductive Strecker Reaction for Late-Stage Amide and Lactam Cyanation

Dr. Ángel L. Fuentes de Arriba, Elena Lenci, Dr. Mahendra Sonawane, Odilon Formery and Prof. Dr. Darren J. Dixon

Iridium-Catalyzed Reductive Strecker Reaction for Late-Stage Amide and Lactam Cyanation

Magic nitrile! A highly chemoselective iridium-catalyzed reductive Strecker reaction of tertiary amides and lactams has been developed. The protocol is simple to perform, broad in scope, highly efficient, and has been successfully applied to the late-stage functionalization of tertiary amides in drugs, naturally occurring alkaloids and peptides. TMDS=tetramethyldisiloxane, TMS=trimethylsilyl, Vaska's complex=IrCl(CO)[P(C6H5)3]2.

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February 24, 2017

News: Pittcon 2017 Award Winners

Pittcon 2017 Award Winners

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February 24, 2017

Hot Paper: Dual Nickel- and Photoredox-Catalyzed Enantioselective Desymmetrization of Cyclic meso-Anhydrides

Erin E. Stache, Prof. Tomislav Rovis and Prof. Abigail G. Doyle

Dual Nickel- and Photoredox-Catalyzed Enantioselective Desymmetrization of Cyclic meso-Anhydrides

Catalytic teamwork: Cyclic anhydrides are efficiently desymmetrized through dual nickel- and photoredox-catalyzed alkylation using benzylic trifluoroborates salts as pronucleophiles. A mechanistic nuance illustrates that an intermediate in the catalytic cycle undergoes epimerization leading to trans keto-acid products from cis anhydrides under modified reaction conditions.

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February 24, 2017

Hot Paper: Reduced SnO2 Porous Nanowires with a High Density of Grain Boundaries as Catalysts for Efficient Electrochemical CO2-into-HCOOH Conversion

Bijandra Kumar, Veerendra Atla, J. Patrick Brian, Sudesh Kumari, Tu Quang Nguyen, Mahendra Sunkara and Dr. Joshua M. Spurgeon

Reduced SnO2 Porous Nanowires with a High Density of Grain Boundaries as Catalysts for Efficient Electrochemical CO2-into-HCOOH Conversion

Against the grain: An electrochemically reduced SnO2 porous nanowire catalyst (Sn-pNWs) with a high density of grain boundaries (GBs) has an energy conversion efficiency for CO2-into-HCOOH that is higher than analogous catalysts of reduced SnO2-based materials. The high density of GBs within the porous structure is decisive.

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February 24, 2017

Hot Paper: A Phosphorus Bisylide: Exploring a New Class of Superbases with Two Interacting Carbon Atoms as Basicity Centers

Dr. Julius F. Kögel, Dr. Davor Margetić, Dr. Xiulan Xie, Dr. Lars H. Finger and Prof. Dr. Jörg Sundermeyer

A Phosphorus Bisylide: Exploring a New Class of Superbases with Two Interacting Carbon Atoms as Basicity Centers

Ping-pong with protons: The first superbase with two interacting P-ylide entities lets a proton bounce between two carbon atoms and exhibits a remarkable proton affinity with an experimental pKBH+ value of 33.3±0.2 on the MeCN scale. The high basicity arises from the rapid exchange of the “acidic” proton between the two basic carbon atoms after protonation.

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February 23, 2017

News: ADUC Prizes/Carl Duisberg Memorial Prize for Shigeyoshi Inoue/Horst Pracejus Prize for Thorsten Bach/Elisabeth Lutz Prize for Nuno Maulide

ADUC Prizes/Carl Duisberg Memorial Prize for Shigeyoshi Inoue/Horst Pracejus Prize for Thorsten Bach/Elisabeth Lutz Prize for Nuno Maulide

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February 23, 2017

VIP: Two-Phase Reactions in Microdroplets without the Use of Phase-Transfer Catalysts

Dr. Xin Yan, Dr. Heyong Cheng and Prof. Richard N. Zare

Two-Phase Reactions in Microdroplets without the Use of Phase-Transfer Catalysts

It's all about the interface: Biphasic reactions are carried out in microdroplets without using a phase-transfer catalyst. Reactions occur within milliseconds in moderate to good yields.

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February 21, 2017

Hot Paper: Detection of Palladium(I) in Aerobic Oxidation Catalysis

Jonathan N. Jaworski, Scott D. McCann, Dr. Ilia A. Guzei and Prof. Shannon S. Stahl

Detection of Palladium(I) in Aerobic Oxidation Catalysis

Catalyst entanglement: Catalyst dimerization is observed in both the aerobic palladium-catalyzed allylic C−H acetoxylation and aza-Wacker cyclization. A novel PdI species is rigorously characterized in catalysis which has implications for palladium catalyst design and presents insights into catalyst deactivation.

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February 21, 2017

VIP: Understanding of Strain Effect in Electrochemical Reduction of CO2: Using Pd Nanostructures as an Ideal Platform

Dr. Hongwen Huang, Huanhuan Jia, Zhao Liu, Pengfei Gao, Jiangtao Zhao, Prof. Zhenlin Luo, Prof. Jinlong Yang and Prof. Jie Zeng

Understanding of Strain Effect in Electrochemical Reduction of CO2: Using Pd Nanostructures as an Ideal Platform

No strain, no gain: Pd octahedra and icosahedra with similar sizes are used as a well-defined platform to study the effect of surface strain in electrochemical reduction of CO2. The results show that tensile strain improves catalytic activity by shifting up the d-band center and thus strengthening the adsorption of key intermediate COOH*.

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February 20, 2017

Angewandte Chemie 10/2017: A Perfect Ten

Angewandte Chemie 10/2017: A Perfect TenIn this issue, M. Bertau et al. review recovery processes and recycling strategies for valuable metals. What are the current trends from antimony to tin via rare earth elements? In the Communications section, M. A. Petrukhina et al. report on a double concave cesium encapsulation by two charged sumanenyl bowls (see picture). G. Pacchioni et al. observed ferromagnetic interactions in highly stable, partially reduced TiO2: the S=2 state in Anatase. S. G. Srivatsan et al. elucidated the structure of the ribosomal RNA decoding site which contains a selenium-modified responsive fluorescent ribonucleoside probe. M. Adeli et al. succeeded in the controlled covalent functionalization of thermally reduced graphene oxide to generate defined bifunctional 2D nanomaterials, and M. Chang et al. describe a one-pot N-deprotection and catalytic intramolecular asymmetric reductive amination for the synthesis of tetrahydroisoquinolines.

Browse issue 10/2017 now.

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February 20, 2017

Hot Paper: Carbonyls as Latent Alkyl Carbanions for Conjugate Additions

Xi-Jie Dai, Dr. Haining Wang and Prof. Dr. Chao-Jun Li

Carbonyls as Latent Alkyl Carbanions for Conjugate Additions

Hidden talents: Carbonyls can act as latent carbon nucleophiles for conjugate additions through a ruthenium-catalyzed process. The reaction relies on homogeneous ruthenium(II) catalysis combined with phosphines as spectator ligands and hydrazine as the reducing agent. This method enables the incorporation of highly functionalized alkyl fragments into a vast array of electron-deficient olefins under mild reaction conditions.

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February 20, 2017

Hot Paper: Energy Transfer Dynamics of Formate Decomposition on Cu(110)

Jiamei Quan, Prof. Takahiro Kondo, Prof. Guichang Wang and Prof. Junji Nakamura

Energy Transfer Dynamics of Formate Decomposition on Cu(110)

CO2 desorption during formate decomposition in the steady-state reaction of HCOOH with O2 on Cu(110) is a thermal non-equilibrium process. During formate decomposition a large amount of released energy is transformed into the internal energies of CO2 molecules, which supports an Eley–Rideal-type mechanism for formate synthesis on copper catalysts.

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February 27, 2017
VIP: Iridium-Catalyzed Reductive Strecker Reaction for Late-Stage Amide and Lactam Cyanation

February 24, 2017
News: Pittcon 2017 Award Winners

February 24, 2017
Hot Paper: Dual Nickel- and Photoredox-Catalyzed Enantioselective Desymmetrization of Cyclic meso-Anhydrides

February 24, 2017
Hot Paper: Reduced SnO2 Porous Nanowires with a High Density of Grain Boundaries as Catalysts for Efficient Electrochemical CO2-into-HCOOH Conversion

February 24, 2017
Hot Paper: A Phosphorus Bisylide: Exploring a New Class of Superbases with Two Interacting Carbon Atoms as Basicity Centers

February 23, 2017
News: ADUC Prizes/Carl Duisberg Memorial Prize for Shigeyoshi Inoue/Horst Pracejus Prize for Thorsten Bach/Elisabeth Lutz Prize for Nuno Maulide

February 23, 2017
VIP: Two-Phase Reactions in Microdroplets without the Use of Phase-Transfer Catalysts

February 21, 2017
Hot Paper: Detection of Palladium(I) in Aerobic Oxidation Catalysis

February 21, 2017
VIP: Understanding of Strain Effect in Electrochemical Reduction of CO2: Using Pd Nanostructures as an Ideal Platform

February 20, 2017
Angewandte Chemie 10/2017: A Perfect Ten

February 20, 2017
Hot Paper: Carbonyls as Latent Alkyl Carbanions for Conjugate Additions

February 20, 2017
Hot Paper: Energy Transfer Dynamics of Formate Decomposition on Cu(110)

February 17, 2017
VIP: Palladium-Mediated Arylation of Lysine in Unprotected Peptides

February 16, 2017
Hot Paper: Photoresponsive Nanosheets of Polyoxometalates Formed by Controlled Self-Assembly Pathways

February 16, 2017
Hot Paper: Cation-Selective Channel Regulated by Anions According to Their Hofmeister Ranking

February 16, 2017
Hot Paper: In Vivo Gold Complex Catalysis within Live Mice

February 15, 2017
VIP: Oxygen Activated, Palladium Nanoparticle Catalyzed, Ultrafast Cross-Coupling of Organolithium Reagents

February 14, 2017
Angewandte Chemie 9/2017: Efficient Access

February 13, 2017
News: First Air Liquide Awards on Essential Small Molecules/Wolf Prize in Chemistry for Robert G. Bergman/Swiss Chemical Society Awards/And also in the News

February 10, 2017
VIP: Hydronium-Ion Batteries with Perylenetetracarboxylic Dianhydride Crystals as an Electrode

February 10, 2017
VIP: High-Power Actuation from Molecular Photoswitches in Enantiomerically Paired Soft Springs

February 10, 2017
VIP: Selected Mutations Reveal New Intermediates in the Biosynthesis of Mupirocin and the Thiomarinol Antibiotics

February 09, 2017
Hot Paper: Photocatalysis with Quantum Dots and Visible Light: Selective and Efficient Oxidation of Alcohols to Carbonyl Compounds through a Radical Relay Process in Water

February 09, 2017
VIP: The Parent Cyclopentadienyltin Cation, Its Toluene Adduct, and the Quadruple-Decker [Sn3Cp4]2+

February 08, 2017
Hot Paper: Chelator-Free Radiolabeling of Nanographene: Breaking the Stereotype of Chelation

February 08, 2017
Hot Paper: Combined Phosphoramidite-Phosphodiester Reagents for the Synthesis of Methylene Bisphosphonates

February 08, 2017
Hot Paper: Catalytic Alkylation Using a Cyclic S-Adenosylmethionine Regeneration System

February 08, 2017
VIP: Synthetic Channel Specifically Inserts into the Lipid Bilayer of Gram-Positive Bacteria but not that of Mammalian Erythrocytes

February 07, 2017
Hot Paper: Automated Synthesis of Well-Defined Polymers and Biohybrids by Atom Transfer Radical Polymerization Using a DNA Synthesizer

February 07, 2017
VIP: Multidimensional SuFEx Click Chemistry: Sequential Sulfur(VI) Fluoride Exchange Connections of Diverse Modules Launched From An SOF4 Hub

February 07, 2017
Angewandte Chemie 8/2017: Activate!

February 06, 2017
Hot Paper: Mapping-Out Catalytic Processes in a Metal–Organic Framework with Single-Crystal X-ray Crystallography

February 06, 2017
Hot Paper: Strain-Promoted Thiol-Mediated Cellular Uptake of Giant Substrates: Liposomes and Polymersomes

February 06, 2017
Hot Paper: The Triply Deprotonated Acetonitrile Anion CCN3− Stabilized in a Solid

February 06, 2017
Hot Paper: Production of Primary Amines by Reductive Amination of Biomass-Derived Aldehydes/Ketones

February 06, 2017
VIP: High-Throughput Synthesis of Mixed-Metal Electrocatalysts for CO2 Reduction

February 06, 2017
VIP: Ultra-Fast Supercritical Hydrothermal Synthesis of Tobermorite under Thermodynamically Metastable Conditions

February 06, 2017
VIP: Bioelectrochemical Haber–Bosch Process: An Ammonia-Producing H2/N2 Fuel Cell

February 03, 2017
VIP: By-Product-Free Siloxane-Bond Formation and Programmed One-Pot Oligosiloxane Synthesis

February 02, 2017
Hot Paper: Enrichment of Specifically Labeled Proteins by an Immobilized Host Molecule

February 02, 2017
Hot Paper: Design, Synthesis, and Photovoltaic Characterization of a Small Molecular Acceptor with an Ultra-Narrow Band Gap

February 01, 2017
Hot Paper: Poly(p-phenylene iminoborane): A Boron–Nitrogen Analogue of Poly(p-phenylene vinylene)

February 01, 2017
Hot Paper: Anaerobe-Inspired Anticancer Nanovesicles

February 01, 2017
Hot Paper: Efficient Hydrogen Evolution Electrocatalysis Using Cobalt Nanotubes Decorated with Titanium Dioxide Nanodots

January 30, 2017
Angewandte Chemie 7/2017: Providing Insight

January 30, 2017
News: Israel Chemical Society Prizes 2016 / Gottfried Wilhelm Leibniz Prize / Adolf Lieben Lectureship for Alois Fürstner

January 30, 2017
Hot Paper: Retention of the Zn−Zn bond in [Ge9Zn−ZnGe9]6− and Formation of [(Ge9Zn)−(Ge9)−(ZnGe9)]8− and Polymeric 1∞ [−(Ge9Zn)2−−]1

January 30, 2017
Hot Paper: Electrocatalytic Synthesis of Ammonia at Room Temperature and Atmospheric Pressure from Water and Nitrogen on a Carbon-Nanotube-Based Electrocatalyst

January 30, 2017
Hot Paper: Highly Multiplexed Single-Cell In Situ Protein Analysis with Cleavable Fluorescent Antibodies

January 30, 2017
Hot Paper: Catalysis Meets Nonthermal Separation for the Production of (Alkyl)phenols and Hydrocarbons from Pyrolysis Oil

January 30, 2017
Hot Paper: NHC-Organocatalyzed CAr−O Bond Cleavage: Mild Access to 2-Hydroxybenzophenones

January 30, 2017
Hot Paper: Turn-On Fluorescence in Tetra-NHC Ligands by Rigidification through Metal Complexation: An Alternative to Aggregation-Induced Emission

January 30, 2017
Hot Paper: The Role of Holes in Borophenes: An Ab Initio Study of Their Structure and Stability with and without Metal Templates

January 30, 2017
VIP: An Electron Acceptor with Porphyrin and Perylene Bisimides for Efficient Non-Fullerene Solar Cells

January 27, 2017
Hot Paper: General Enantioselective C−H Activation with Efficiently Tunable Cyclopentadienyl Ligands

January 26, 2017
Hot Paper: Photoelectrochemical Reduction of Carbon Dioxide to Methanol through a Highly Efficient Enzyme Cascade

January 25, 2017
VIP: Deprotonation of a Hydridoborate Anion

January 24, 2017
Hot Paper: Real-Time Monitoring of Nanoparticle Formation by FRET Imaging

January 24, 2017
Hot Paper: Accessing the Intrinsic Nature of Electronic Transitions from Gas-Phase Spectroscopy of Molecular Ion/Zwitterion Complexes

January 24, 2017
Hot Paper: Enantioselective Copper-Catalyzed Intermolecular Amino- and Azidocyanation of Alkenes in a Radical Process

January 24, 2017
VIP: The Catalytic Mechanism of the Class C radical S-Adenosylmethionine Methyltransferase NosN

January 23, 2017
Hot Paper: Peptide N-Amination Supports β-Sheet Conformations

January 23, 2017
Hot Paper: Micromotors Spontaneously Neutralize Gastric Acid for pH-Responsive Payload Release

January 23, 2017
VIP: Polymer-Templated Formation of Polydopamine-Coated SnO2 Nanocrystals: Anodes for Cyclable Lithium-Ion Batteries

January 20, 2017
News: Science Award Electrochemistry for William C. Chueh/

January 20, 2017
Hot Paper: Plasmonic Chirality Imprinting on Nucleobase-Displaying Supramolecular Nanohelices by Metal–Nucleobase Recognition

January 19, 2017
Hot Paper: Palladium-Catalyzed Hydrolytic Cleavage of Aromatic C−O Bonds

January 19, 2017
Hot Paper: In Vivo Dearomatization of the Potent Antituberculosis Agent BTZ043 via Meisenheimer Complex Formation

January 19, 2017
Hot Paper: Social Self-Sorting of Colloidal Families in Co-Assembling Microgel Systems

January 19, 2017
Hot Paper: Biosynthesis of the Carbonylmethylene Structure Found in the Ketomemicin Class of Pseudotripeptides

January 19, 2017
Hot Paper: Water-Enabled Catalytic Asymmetric Michael Reactions of Unreactive Nitroalkenes: One-Pot Synthesis of Chiral GABA-Analogs with All-Carbon Quaternary Stereogenic Centers

January 19, 2017
VIP: Breaking the Tetra-Coordinated Framework Rule: New Clathrate Ba8M24P28+δ (M=Cu/Zn)

January 19, 2017
VIP: Solution Synthesis, Structure, and CO2 Reduction Reactivity of a Scandium(II) Complex, {Sc[N(SiMe3)2]3}

January 17, 2017
News: Académie des Sciences Prizes/Novartis Chemistry Lectureship 2016–2017

January 17, 2017
Hot Paper: Diversity-Oriented Synthesis of Cyclic Azapeptides by A3-Macrocyclization Provides High-Affinity CD36-Modulating Peptidomimetics

January 17, 2017
Hot Paper: Electrochemically Driven Transformation of Amorphous Carbons to Crystalline Graphite Nanoflakes: A Facile and Mild Graphitization Method

January 17, 2017
VIP: Bi(IO3)F2: The First Metal Iodate Fluoride with a Very Strong Second Harmonic Generation Effect

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