Angewandte Chemie International Edition

Cover image for Vol. 53 Issue 17

Editor: Peter Gölitz, Deputy Editors: Neville Compton, Haymo Ross

Online ISSN: 1521-3773

Associated Title(s): Angewandte Chemie, Chemistry - A European Journal, Chemistry – An Asian Journal, Zeitschrift für Chemie

Press Release

For full article and contact information, see Angew. Chem. Int. Ed. 2003, 42 (36), 4370—4373

No. 36/2003

Radical Interceptor

More effective than vitamin E: a new class of antioxidants

Fat goes rancid over time if no antioxidants are added. Our bodies also contain fat molecules, called lipids. They are essential for our cell membranes. These too must be protected from excessive peroxidation; left unchecked, it can cause atherosclerosis or various autoimmune and neurodegenerative diseases, such as Alzheimer’s disease, to set in. Nature’s most important weapon in defense of lipid peroxidation is vitamin E (alpha-tocopherol). An international team of researchers working with Derek A. Pratt (Vanderbilt University, USA) has now developed a new class of antioxidants that are up to 100 times more effective than vitamin E.

The trouble with the peroxidation of lipids is that it is a chain reaction. In the first step, an oxygen radical—a molecule with an unpaired electron on an oxygen atom, removes a hydrogen atom from a lipid. This leaves behind a lipid radical, which has an unpaired electron on a carbon atom, which reacts with an oxygen molecule to form a lipid peroxyl radical. This is an oxygen radical that can then attack another lipid in turn—in order to steal a hydrogen atom—resulting in yet another lipid radical.The vicious circle starts all over again and is difficult to stop. This is where antioxidants like alpha-tocopherol come into the picture; they intercept the lipid peroxyl radicals. Radical scavengers like tocopherol are phenols, they consist of a six-membered aromatic carbon ring with an attached oxygen atom, and this oxygen atom carries a hydrogen atom (an OH group). This hydrogen atom is stripped away by the peroxyl radical. In contrast to the lipid radicals, the resulting phenolic radical is relatively unreactive, and the chain reaction stops. In order to find an even better radical interceptor, the chemists searched for a phenolic compound, whose OH group gives up its hydrogen atom more easily than vitamin E. However, most of these super radical scavengers are much to readily attacked by oxygen in the air to be useful.

Computer simulations enabled Pratt and his co-workers to develop a new class of air-stable phenolic antioxidants. Subsequent experiments have demonstrated that two of these amino pyridinol compounds, as they are called, are particularly effective radical scavengers. They consist of a phenol ring, in which one of the carbon atoms has been replaced with a nitrogen atom. This aromatic (containing three double bonds) ring is fused with another, aliphatic (containing only single bonds) carbon ring, which also contains a nitrogen atom. "These amino pyridinols are, to the best of our knowledge, the fastest peroxyl-radical-trapping antioxidants ever reported," says Pratt.