Angewandte Chemie International Edition
Copyright © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Angewandte Chemie International Edition 2006, 45, 6877–6882
Simultaneous production of microchannels with parallel, electrically conducting metal wires
Magnetic components that can be controlled by the application of an external electric field are useful in many different applications. They can serve as microfluidic pumps, mixers, or valves in miniature lab-on-chip systems, or they can help in sorting and arranging magnetic particles. Biochemistry and cellular biology in particular benefit from many possible uses: for example, antibodies or other ligands that bind to individual biomolecules or to surface structures of cells can be coupled to magnetic beads in order to recognize and bind to their specific bonding partner even in complex mixtures. They can subsequently be fished out of the mixture with an electromagnet. Electromagnets have an additional advantage over permanent magnets: they can easily be switched on and off with an electric current. Also, the field strength can be adjusted to the desired value and can be changed as required. However, electromagnets do have the disadvantage of generating weaker magnetic fields, meaning that they must be very close to the place where they are to be used.
G. M. Whitesides and his co-workers at Harvard University in Cambridge, USA, have now developed an uncomplicated method for producing a microfluidic channel along with two metal cables parallel to it and only 10 µm away. First, a structure consisting of a 40-µm-wide and 40-µm-deep inner channel between two 120-µm-wide and 40-µm-deep outer channels was lithographically engraved into a polydimethylsiloxane resin. Treatment with 3-mercaptopropyltrimethoxysilane silanized the surfaces of the outer channels. This allowed them to be coated with molten solder that was poured into the heated forms in the next step. Upon cooling, the liquid metal solidified, forming two stable metal cables to the left and right of the inner channel. Application of an electrical field to these two wires generates magnetic fields of up to 2.8 mT within the central channel.
It was also possible to steer magnetic spheres through the channel: the scientists again made a channel with parallel wires on either side, but this time the channel forked after a few millimeters. A suspension of magnetic spheres flowed through the channel. If current was allowed to flow through wire on the right, the spheres flowed to the right as they reached the fork, and vice versa.