Macromolecular Symposia

Cover image for Vol. 374 Issue 1

December 16, 2010

Stem Cells: How to Sterilize PET Fibers for Vascular Grafts

Stem Cells: How to Sterilize PET Fibers for Vascular Grafts

Sashka Dimitrievska, Alain Petit, Charles J. Doillon, Laura Epure, Abdellah Ajji, L'Hocine Yahia, and Martin N. Bureau

Polyethylene terephthalate (PET) scaffold with mechanical properties similar to those of small arteries constitute an attractive candidate for regenerative medicine and tissue engineering with observed stem cell differentiation potential. One of the essential pre-conditions for further clinical application is the ability of the scaffold to withstand sterilization. Martin N. Bureau and co-workers investigate the effect of low temperature plasma (LTP) and ethylene oxide (EtO) sterilizations on PET vascular grafts in terms of chemical modifications and in vitro and in vivo biocompatibility. While their in vitro cytotoxicity shows similar fibroblastic viability, non-woven PET fibers sterilized using EtO and low LTP show different macrophage activation in both direct and indirect macrophage contact assays.

Macromol. Biosci., DOI: 10.1002/mabi.201000268

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