Macromolecular Symposia

Cover image for Vol. 373 Issue 1

January 25, 2011

Polymer Conjugates: Grafting-from and RAFT Polymerization - A Powerful Combination

Polymer Conjugates: Grafting-from and RAFT Polymerization - A Powerful Combination

Ming Li, Hongmei Li, Priyadarsi De, and Brent S. Sumerlin*

Modification of biomacromolecules with synthetic polymers is an effective means to enhance the solubility, biocompatibility, stability and activity of proteins, nucleic acids, and polysaccharides, potentially enabling a variety of new biotechnology applications. The group of Brent Sumerlin (Dallas, USA) presents the first example of combining the grafting-from and RAFT technique, providing a new method for the preparation of block copolymer polymer-protein conjugates. The resulting conjugates prepared by two consecutive grafting-from reactions via RAFT polymerization exhibit thermoresponsive behavior due to the temperature-sensitivity of the PNIPAM block.
This article is addtionally featured on MaterialsViews.

Macromol. Rapid Commun., DOI: 10.1002/marc.201000619

Other contributions to the article series on polymer conjugates can be found here.

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