© WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
March 16, 2011
Stem Cells: Injectable Scaffold for Cardiac Tissue Engineering
Jennifer M. Singelyn and Karen L. Christman*
Injectable materials are attractive therapeutic options for cardiac repair, including treatment of the heart following a myocardial infarction (MI), because they offer the potential of minimally invasive delivery. Christman and co-workers have recently developed an injectable hydrogel that is derived from decellularized ventricular tissue. The decellularized myocardium is processed to create a liquid, injectable matrix, thus offering a cardiac specific scaffold. In this study they investigate the effects of cross-linking with glutaraldehyde on the cardiac hydrogel stiffness, degradation properties, cellular migration, and catheter injectability in vitro. While in vivo studies will be critical to validate these findings, this study demonstrates that the material properties of the myocardial matrix can be altered to meet potential tissue engineering requirements for myocardial repair following an MI, while maintaining catheter injectability.
Macromol. Biosci., DOI: 10.1002/mabi.201000423
Other contributions to the article series on stem cells can be found here.