Macromolecular Symposia

Cover image for Vol. 372 Issue 1

April 05, 2011

Stem Cells: Polymeric Scaffold for Adipose Stem Cells in Bone Tissue Engineering

Stem Cells: Polymeric Scaffold for Adipose Stem Cells in Bone Tissue Engineering

Pieter-Paul A. Vergroesen, Robert-Jan Kroeze, Marco N. Helder, and Theodoor H. Smit*

In orthopaedics, there is an unmet need for graft material to provide support, fill voids and enhance biological repair of bone defects. Using donor bone from the patient (autografts) has been the standard procedure as it is well established, safe, relatively cheap, however, it also involves an additional surgery that is associated with pain, infections, vascular injuries etc. Allografts (bone from other patients stored in a bone bank) is a reasonable alternative but has disadvantages such as non-specific inflammations and prolonged healing times. Fat-derived stem cells and synthetic polymers open new, more practicable routes for bone tissue engineering. T. H. Smit and co-workers highlight the potential of poly(L-lactide-co-caprolactone) (PLCL) to serve as a radiolucent scaffold in bone tissue engineering. An in vivo spinal fusion study in a goat model provides a preclinical proof-of-concept for a one-step surgical procedure with ASCs in bone tissue engineering.

Macromol. Biosci., DOI: 10.1002/mabi.201000433

Other contributions to the article series on stem cells can be found here.

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