© WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
October 24, 2011
Stem Cells: Pullulan Hydrogels for Skin Regeneration
Victor W. Wong, Kristine C. Rustad, Jason P. Glotzbach, Michael Sorkin, Mohammed Inayathullah, Melanie R. Major, Michael T. Longaker, Jayakumar Rajadas, and Geoffrey C. Gurtner*
Wound healing after cutaneous injury proceeds through highly coordinated stages of repair to restore the damaged tissues. In the initial stage, reactive oxygen species (ROS) are secreted in order to kill bacteria and defend the disrupted skin barrier. However, an elevated level of ROS may lead to cell damage and an impaired response to injury. G. C. Gurtner and co-workers could now show that pullulan-based hydrogel scaffolds exhibit potent antioxidant properties that enhance the survival and engraftment of mesenchymal stem cells both in vitro and in vivo. This biomimetic hydrogel displays significant potential as a cell-scaffold construct for skin regeneration in high oxidative stress environments.
Macromol. Biosci., DOI: 10.1002/mabi.201100180
Other contributions to the article series on stem cells can be found here.