Macromolecular Symposia

Cover image for Vol. 375 Issue 1

October 24, 2011

Stem Cells: Tissue-Specific Stem Cell Differentiation in an in vitro Airway Model

Stem Cells: Tissue-Specific Stem Cell Differentiation in an in vitro Airway Model

Zoë Prytherch,* Claire Job, Hilary Marshall, Victor Oreffo, Martyn Foster, and Kelly BéruBé

The respiratory tract is the primary site of exposure to airborne compounds, with the bronchial epithelium providing one of the first lines of defense. Developing model systems that imitate normal physiology is important and relevant to today's testing of drugs and other therapies. Z. Prytherch and co-workers developed a fully differentiated in vivo like model of the human bronchial epithelium. Developmental characterization includes (i) trans-epithelial electrical resistance, (ii) morphology, and (iii) bronchial cell specific stains/markers. Characterization at all levels was essential, not only in order to fully validate the model as a viable alternative, but also, to later elucidate the mechanisms of action of the model during injury and repair, either during disease processes or following a challenge with a given xenobiotic.

Macromol. Biosci., DOI: 10.1002/mabi.201100181

Other contributions to the article series on stem cells can be found here.

[Browse more news]

SEARCH

SEARCH BY CITATION