© WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
March 22, 2012
Stem Cells: Polymeric Systems for Tissue Engineering and Biomedical Applications
R. Ravichandran, S. Sundarrajan,* J. R. Venugopal, S. Mukherjee, and S. Ramakrishna*
Smart stimuli-responsive polymeric systems with smart surfaces are used for engineering a biological construct embedded with cells and biomolecules/drugs. Upon suitable stimuli such as pH in vivo, the polymer unwinds and becomes hydrophobic, thereby delivering cells and biomolecules to the target organ in the human body.
S. Ramakrishna and co-workers (National University of Singapore) highlight the exciting advancements in these polymeric systems that relate to biological and tissue engineering applications. Additionally, several aspects of technology namely scaffold fabrication methods and surface modifications to confer biological functionality to the polymers are being discussed. Their ultimate objective is to emphasize these underutilized adaptive behaviors of the polymers so that novel applications and new generations of smart polymeric materials can be realized for biomedical and tissue engineering applications.
Macromol. Biosci., DOI: 10.1002/mabi.201100325
Other contributions to the article series on stem cells can be found here.