© WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
March 23, 2012
Stem Cells: Gelatin-Based Hydrogels as Potential Implantable Carriers for Stem Cells
Benjamin F. Pierce, Erik Pittermann, Nan Ma, Tim Gebauer, Axel T. Neffe, Magdalena Hoelscher, Friedrich Jung, and Andreas Lendlein*
Common polymeric bulk materials such as polystyrene, polycarbonate, and poly(propylene) have been successfully applied as substrates for mesenchymal stem cells (MSC) attachment, proliferation, and differentiation. However, these plastics are not ideal as implantable systems for applications in regenerative therapies as more specific requirements such as degradability need to be fulfilled for the next generation of biomaterials. MSC show a high viability on gelatin-based networks with tailorable properties. A. Lendlein and co-workers show that gelatin crosslinked with lysine diisocyanate ethyl ester in water yield degradable, sterilizable, and non-toxic hydrogels. Such materials are promising biomaterial candidates that merit further study as possible stem cell niches.
Macromol. Biosci., DOI: 10.1002/mabi.201100237
Other contributions to the article series on stem cells can be found here.