© WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
August 07, 2012
Stem Cells: Electrospun PLA Fibers for Controlled TCP Release
Mahsa Mohiti Asli, Behnam Pourdeyhimi and Elizabeth G. Loboa*
One of the challenges in bone tissue engineering is to find a scaffold that is biocompatible, degradable, promotes the cellular interactions and possesses adequate mechanical properties. Recent studies showed that the presence of tricalcium phosphate (TCP) induces and accelerates osteogenic differentiation of human adipose-derived stem cells (hASC) and encourages rapid ossification. Researchers around Loboa (North Carolina State University) now created scaffolds that release TCP. They studied PLA based and TCP loaded, electrospun fibers with different fiber morphologies to evaluate release profiles and their effects on hASC differentiation. Single component and porous fiber scaffolds show a burst release whereas core-stealth fibers show a steady release. These findings will be of great importance for bone tissue engineering applications.
Macromol. Biosci., DOI: 10.1002/mabi.201100470
Other contributions to the article series on stem cells can be found here.