© WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
August 15, 2012
Stem Cells: Artificial Organs
Achala de Mel, Alexander M. Seifalian,* Martin A. Birchall
This review by Alexander M. Seifalian (University College London) gives a deep and comprehensive understanding of the design, methods, and complexity of materials used to mimic and replace organs. Reconstruction and replacement of organs with tissue engineered materials is becoming reality as first-in-man experiences have been successful. One of the challenges in this field is to integrate cells into predesigned 3D materials. Greater integration of cells with biomaterial scaffolds requires biochemical modifications and topographical changes, which could create an artificial niche for cells to reside within the 3D scaffolds. Therefore, precise knowledge of cell/material interactions is indispensable. The review covers several aspects of tissue engineering like complexity of tissue-engineered implants, scaffold design for structural support, cell/material interactions and live monitoring of cell/material interactions.
Macromol. Biosci., DOI: 10.1002/mabi.201200039
Other contributions to the article series on stem cells can be found here.