Macromolecular Symposia

Cover image for Vol. 377 Issue 1

July 29, 2013

Stem Cells: In Vitro Neo-Cartilage Formation

Stem Cells: In Vitro Neo-Cartilage Formation

Sumrita Bhat, Lars Lidgren and Ashok Kumar*

Limited blood supply and the avascular nature of articular cartilage restrict its self-repair capacity, frequently leading to osteoarthritis. Researchers from India and Sweden focus on scaffolds for tissue repair from natural polymers, for example gelatin, chitosan, and agarose in the form of composites. A novel way of fabrication, known as cryogelation, is presented, in which matrices are synthesized at sub-zero temperature. Cell seeded scaffolds incubated under appropriate conditions result in the accumulation of matrix components on the surface of the gel in the form of neo-cartilage. Neo-cartilage exhibits similarity to native cartilage with respect to its physical, mechanical and biochemical properties. Based on these similarities it can provide a new approach for the treatment of localized joint injuries.

Macromol. Biosci., DOI: 10.1002/mabi.201200484

Other contributions to the article series on stem cells can be found here.

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