Macromolecular Rapid Communications
Copyright © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Editors: Kirsten Severing , Stefan Spiegel
Online ISSN: 1521-3927
Recently Published Articles
- Topology-Dependent Swichability of Peptide Secondary Structures in Bioconjugates with Complex Architectures
Hans G. Börner, Romina I. Sütterlin, Patrick Theato and Kerstin T. Wiss
Article first published online: 9 DEC 2013 | DOI: 10.1002/marc.201300808
The effect of conjugate topology on the reversible pH-responsive coil to α-helix secondary structure transition is described. Three peptide–polymer conjugates are synthesized, exhibiting similar poly(ethylenoxid) blocks but differing in topologies of the peptide bearing blocks. The study compares structural transitions and self-assembly of linear AB-bioconjugates with graft ABA-bioconjugates having multiple peptide segments combined in star or pom-pom topologies.
- Redox-Triggered Self-Rolling Robust Hydrogel Tubes for Cell Encapsulation
Lu Liu, Ning Wang, Yanjiao Han, Yongmao Li and Wenguang Liu
Article first published online: 9 DEC 2013 | DOI: 10.1002/marc.201300784
The multiple hydrogen bonding-strengthened hydrogels are synthesized and this bilayer hydrogel with different cross-linking density can curl up automatically into a 3D tube. At an intracellular level of GSH, cells-seeded bilayer gel sheet self-folds into a 3D tubular scaffold meanwhile maintaining better viability. This self-shaping 3D hydrogel tube holds great potential as a programmable tissue engineering scaffold.
- A Stimuli-Responsive Nanogel-Based Sensitive and Selective Fluorescent Sensor for Cr3+ with Thermo-Induced Tunable Detection Sensitivity
Xuejuan Wan, Haiyang Liu, Shen Yao, Tianqi Liu and Youwei Yao
Article first published online: 9 DEC 2013 | DOI: 10.1002/marc.201300810
Fluorescent thermo-responsive nanogel-based Cr3+ sensor with tunable detection sensitivity is fabricated via free radical emulsion copolymerization. The obtained nanogel exhibits prominent fluorescence OFF–ON switching after the recognition of Cr3+ in water. Ascribing to the phase transition behavior of responsive polymer matrix, detection performance of the nanogel can be further optimized at elevated temperature with a detection limit of 9.1 × 10−8m.
- Incorporation of 5-Hydroxyindazole into the Self-Polymerization of Dopamine for Novel Polymer Synthesis
Matthew B. Peterson, Solomon P. Le-Masurier, Khoon Lim, James M. Hook, Penny Martens and Anthony M. Granville
Article first published online: 9 DEC 2013 | DOI: 10.1002/marc.201300746
The self-polymerization of dopamine is extended to incorporate 5-hydroxyindazole into the polymerization system. The structurally similar indazole can oxidatively couple in the same fashion as dopamine, proof that the polymerization reaction is expandable to other materials for new green chemistry reactions.
- “Bio”-Macromolecules: Polymer-Protein Conjugates as Emerging Scaffolds for Therapeutics
Dorothee E. Borchmann, Tom P. Carberry and Marcus Weck
Article first published online: 9 DEC 2013 | DOI: 10.1002/marc.201300792
Macromolecules assemble! Polymer-protein conjugates unify the benefits of both the synthetic and biological worlds. From one side, engineered polymers endow conjugates with any number of properties; from the other, proteins allow for nature's perfect syntheses and complex interactions. This review presents recent developments in the field and their applications toward biomedical chemistry.