Macromolecular Rapid Communications

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Recently Published Articles

  1. Tumor-Acidity Activated Surface Charge-Conversion of Polymeric Nanocarriers for Enhanced Cell Adhesion and Targeted Drug Release

    Wei Wu, Jiantao Wang, Zaifu Lin, Xiuhua Li and Jianshu Li

    Article first published online: 29 AUG 2014 | DOI: 10.1002/marc.201400362

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    The preparation of PLA-b-PAEMA/DMMA is discussed, since it can undergo a timely surface charge-conversion from negative to positive in response to the slight acidity of the tumor extracellular matrix. This can enhance tumor cell adhesion and targeted drug release for potential tumor therapy applications.

  2. Multi-Responsive Polypeptidosome: Characterization, Morphology Transformation, and Triggered Drug Delivery

    Gang Liu, Linzhu Zhou, Yanfei Guan, Yue Su and Chang-Ming Dong

    Article first published online: 29 AUG 2014 | DOI: 10.1002/marc.201400343

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    A novel multi-responsive polypeptide-based vesicle (polypeptidosome) is fabricated by controlling the structure transformation of one polypeptide block copolymer, and it presents the combined sensitivity of multiple physiological and clinic-related stimuli. The anticancer drug doxorubicin can be released in a controlled or on–off manner, enabling the polypeptidosome useful for on-demand nanomedicine and cancer therapy.

  3. One-Step Synthesis of Natural Silk Sericin-Based Microcapsules with Bionic Structures

    Zhaogang Liu, Yurong Cai, Yaru Jia, Lin Liu, Xiangdong Kong, Subhas C. Kundu and Juming Yao

    Article first published online: 28 AUG 2014 | DOI: 10.1002/marc.201400304

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    A one-step and environment-friendly method is developed to generate a series of silk sericin-based microcapsules with bionic structures depending on the change of Ca2+ concentration and agitation speed. The as-prepared cocoon-like microcapsules exhibit a pH-dependent stability with potential applications as controlled bioactive molecules loading and a release system.

  4. Supramolecular Adhesives to Hard Surfaces: Adhesion Between Host Hydrogels and Guest Glass Substrates Through Molecular Recognition

    Yoshinori Takashima, Taiga Sahara, Tomoko Sekine, Takahiro Kakuta, Masaki Nakahata, Miyuki Otsubo, Yuichiro Kobayashi and Akira Harada

    Article first published online: 27 AUG 2014 | DOI: 10.1002/marc.201400324

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    Hydrogels with cyclic host molecules selectively adhere to guest molecules modified glass substrates. Adhesion depends on the affinity of guest molecules with host molecules. External stimuli regulate the adhesion between host hydrogels and guest substrates. The host molecules of the host hydrogel precisely recognize the hydrophobicity of guest molecules on the glass substrates to create an adhesive force.

  5. Stable Cross-linked Fluorescent Polymeric Nanoparticles for Cell Imaging

    Haiyin Li, Xiqi Zhang, Xiaoyong Zhang, Bin Yang, Yang Yang and Yen Wei

    Article first published online: 27 AUG 2014 | DOI: 10.1002/marc.201400309

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    Stable cross-linked fluorescent polymeric nanoparticles are facilely prepared based on an aggregation-induced emission dye via a two-step polymerization including emulsion polymerization and subsequent anhydride cross-linking. These cross-linked polymers are easy to self-assemble into uniform nanoparticles that show high water dispersibility, intense red fluorescence, and excellent biocompatibility, making them promising for cell imaging applications.