Macromolecular Rapid Communications

Cover image for Vol. 35 Issue 24

July 08, 2010

Polymer Conjugates: Cell Receptor-Responsiveness and Targeted Delivery of Growth Factors

Polymer Conjugates: Cell Receptor-Responsiveness and Targeted Delivery of Growth Factors

Sung Hye Kim and Kristi L. Kiick*

Engineered delivery systems for bioactive signaling molecules, such as growth factors (GFs), have been extensively studied, because these vehicles provide stabilization of GF activity and prolonged delivery. Kristi Kiick's group has studied cell receptor-responsiveness and targeted delivery of the vascular endothelial growth factor (VEGF) from non-covalently assembled, heparinized polymeric hydrogels. The hydrogel is formed via specific non-covalent interactions between 4-arm star poly(ethylene glycol)-heparin and dimeric VEGF. They could show that growth factor-crosslinked hydrogels can liberate VEGF in response to specific receptors, causing gel erosion and desired cell responses, thus suggesting the potential utility of these materials in therapeutic applications, including targeted delivery.

Macromol. Rapid Commun., DOI: 10.1002/marc.201000130

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